Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

Frequent Endonuclease Cleavage at Off-target Locations In Vivo

(2010) Lisa M Petek et al.   MOLECULAR THERAPY

Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA Deaminases

(2009) S. Pauklin et al.   GENETICS

Exploitation of binding energy for catalysis and design

(2009) Summer B. Thyme et al.   NATURE

Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease

(2009) G. P. van Nierop et al.   NUCLEIC ACIDS RESEARCH

Site-specific integration of adeno-associated virus involves partial duplication of the target locus

(2009) E. Henckaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

(2009) A. McConnell Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

(2009) Makoto Nakahara et al.   PLoS Genetics

Human Gene Targeting Favors Insertions Over Deletions

(2008) David W. Russell et al.   HUMAN GENE THERAPY

Engineering Variants of the I-SceI Homing Endonuclease with Strand-specific and Site-specific DNA-nicking Activity

(2008) Yan Niu et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

(2008) Ryo Takeuchi et al.   NUCLEIC ACIDS RESEARCH