The RNA-dependent RNA polymerase of the influenza A virus

Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A/H7N9 Influenza Virus in Mammalian Hosts

(2014) C. K. P. Mok et al.   JOURNAL OF VIROLOGY

Influenza Viruses and mRNA Splicing: Doing More with Less

(2014) J. Dubois et al.   mBio

New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain

(2013) Stéphane Pautus et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

(2013) J. S. Long et al.   JOURNAL OF VIROLOGY

Host Restriction of Influenza Virus Polymerase Activity by PB2 627E Is Diminished on Short Viral Templates in a Nucleoprotein-Independent Manner

(2013) D. Paterson et al.   JOURNAL OF VIROLOGY

Uncoupling of Influenza A Virus Transcription and Replication through Mutation of the Unpaired Adenosine in the Viral RNA Promoter

(2013) A. J. W. te Velthuis et al.   JOURNAL OF VIROLOGY

Universal influenza virus vaccines: need for clinical trials

(2013) Florian Krammer et al.   NATURE IMMUNOLOGY

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

(2013) Kausiki Datta et al.   NUCLEIC ACIDS RESEARCH

Asparagine Substitution at PB2 Residue 701 Enhances the Replication, Pathogenicity, and Transmission of the 2009 Pandemic H1N1 Influenza A Virus

(2013) Bin Zhou et al.   PLoS One

Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus

(2013) A. York et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes

(2013) Lauren Turrell et al.   Nature Communications

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

(2013) Benjamin Mänz et al.   PLoS Pathogens

Antivirals Targeting Influenza A Virus

(2012) Kalyan Das   JOURNAL OF MEDICINAL CHEMISTRY

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

Unstable Polymerase-Nucleoprotein Interaction Is Not Responsible for Avian Influenza Virus Polymerase Restriction in Human Cells

(2012) A. V. Cauldwell et al.   JOURNAL OF VIROLOGY

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in Mice

(2012) L. Qi et al.   JOURNAL OF VIROLOGY

Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis

(2012) J. K. Marklund et al.   JOURNAL OF VIROLOGY

Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice

(2012) Wenfei Zhu et al.   PLoS One

Functional Analysis of Conserved Motifs in Influenza Virus PB1 Protein

(2012) Caroline Chu et al.   PLoS One

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

(2012) G. Muratore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Native Influenza Virion Ribonucleoproteins

(2012) R. Arranz et al.   SCIENCE

Organization of the Influenza Virus Replication Machinery

(2012) A. Moeller et al.   SCIENCE

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Broadly neutralizing antibodies against influenza virus and prospects for universal therapies

(2012) Damian C Ekiert et al.   Current Opinion in Virology

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function

(2011) Song Gao et al.   IMMUNITY

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex

(2011) Shilpa Aggarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

(2011) A. Foeglein et al.   JOURNAL OF GENERAL VIROLOGY

Behaviour of influenza A viruses differentially expressing segment 2 gene products in vitro and in vivo

(2011) S. Tauber et al.   JOURNAL OF GENERAL VIROLOGY

The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses

(2011) P. Zimmermann et al.   JOURNAL OF VIROLOGY

Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

(2011) A. Mehle et al.   JOURNAL OF VIROLOGY

Combination of PB2 271A and SR Polymorphism at Positions 590/591 Is Critical for Viral Replication and Virulence of Swine Influenza Virus in Cultured Cells and In Vivo

(2011) Q. Liu et al.   JOURNAL OF VIROLOGY

Reversion of PB2-627E to -627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein

(2011) J. Bogs et al.   JOURNAL OF VIROLOGY

PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

(2011) K. A. Bussey et al.   JOURNAL OF VIROLOGY

Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

(2011) E. Bortz et al.   mBio

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus

(2010) Benjamin Mänz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of an Influenza Virus RNA Polymerase-Genomic RNA Complex

(2010) Patricia Resa-Infante et al.   JOURNAL OF VIROLOGY

Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

(2010) S. Herfst et al.   JOURNAL OF VIROLOGY

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Influenza A virus-generated small RNAs regulate the switch from transcription to replication

(2010) J. T. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2009 A (H1N1) influenza virus pandemic: A review

(2010) Marc P. Girard et al.   VACCINE

Preferential use of RNA leader sequences during influenza A transcription initiation in vivo

(2010) Christina Geerts-Dimitriadou et al.   VIROLOGY

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

(2009) Kanako Sugiyama et al.   EMBO JOURNAL

A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA

(2009) H. M. Wise et al.   JOURNAL OF VIROLOGY

Quaranfil, Johnston Atoll, and Lake Chad Viruses Are Novel Members of the Family Orthomyxoviridae

(2009) R. M. Presti et al.   JOURNAL OF VIROLOGY

Nuclear Import and Assembly of Influenza A Virus RNA Polymerase Studied in Live Cells by Fluorescence Cross-Correlation Spectroscopy

(2009) S. Huet et al.   JOURNAL OF VIROLOGY

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Detection and Characterization of Influenza A Virus PA-PB2 Interaction through a Bimolecular Fluorescence Complementation Assay

(2009) J. N. Hemerka et al.   JOURNAL OF VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Structure and sequence analysis of influenza A virus nucleoprotein

(2009) Andy Ka-Leung Ng et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways

(2009) Margaret A. Scull et al.   PLoS Pathogens

The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex

(2009) Rocío Coloma et al.   PLoS Pathogens

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

Role of Initiating Nucleoside Triphosphate Concentrations in the Regulation of Influenza Virus Replication and Transcription

(2008) F. T. Vreede et al.   JOURNAL OF VIROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit

(2008) Tom S.Y. Guu et al.   VIROLOGY

Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding

(2007) Helena J. Maier et al.   VIROLOGY