Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences

(2011) P. Reuther et al.   JOURNAL OF VIROLOGY

Limited Compatibility of Polymerase Subunit Interactions in Influenza A and B Viruses

(2010) Kerstin Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Influenza Antiviral Resistance Threats

(2010) F. G. Hayden et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis of the Interaction for an Essential Subunit PA−PB1 in Influenza Virus RNA Polymerase: Insights from Molecular Dynamics Simulation and Free Energy Calculation

(2009) Huanxiang Liu et al.   MOLECULAR PHARMACEUTICS

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication

(2009) Kerstin Wunderlich et al.   PLoS One

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities

(2008) Ai-Lin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY