Medicinal applications of perfluoroalkylated chain-containing compounds

Perfluoroalkyl and polyfluoroalkyl substances: current and future perspectives

(2013) Kurunthachalam Kannan   Environmental Chemistry

Sphingosine and clavaminol H derivatives bearing fluorinated chains and their cytotoxic activity

(2012) Eva Prchalová et al.   JOURNAL OF FLUORINE CHEMISTRY

Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60

(2012) Hongqi Li et al.   LETTERS IN ORGANIC CHEMISTRY

Tuning lipase activity with perfluoro carboxylic acids as additives

(2012) Carlos G. Acevedo-Rocha et al.   Catalysis Science & Technology

Attachment of Proteins to Surfaces by Fluorous-Fluorous Interactions Restoring Their Structure and Activity

(2012) Hartmut M. Rapp et al.   ChemPlusChem

Thermoresponsive Chlorambucil Derivatives for Tumour Targeting

(2011) Catherine M. Clavel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist

(2011) Rena Nishizawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

(2011) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acidic triazoles as soluble guanylate cyclase stimulators

(2011) Lee R. Roberts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

(2011) Robert H. Bradbury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functionalization of luminescent cyclometalated iridium(iii) polypyridine complexes with a fluorous moiety: photophysics, protein-binding, bioconjugation, and cellular uptake properties

(2011) Siu-Kit Leung et al.   CHEMICAL COMMUNICATIONS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and biological activity of new bispyridinium salts of 4,4′-bispyridyl-5,5′-perfluoroalkyl-2,2′-bisoxazoles

(2011) Y. Martín-Cantalejo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

(2011) C. Kurumurthy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Luminescent Rhenium(I) Polypyridine Fluorous Complexes as Novel Trifunctional Biological Probes

(2011) Man-Wai Louie et al.   INORGANIC CHEMISTRY

In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon

(2011) Jana Held et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Novel Benzo-1,2,3-thiadiazole-7-carboxylate Derivatives As Plant Activators and the Development of Their Agricultural Applications

(2011) Qingshan Du et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase

(2011) Jasmin Mecinović et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction of a partially fluorinated alcohol (F8H11OH) with biomembrane constituents in two-component monolayers

(2011) Hiromichi Nakahara et al.   Soft Matter

The C–F bond as a conformational tool in organic and biological chemistry

(2010) Luke Hunter   Beilstein Journal of Organic Chemistry

Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2′-deoxyuridines

(2010) Sun Min Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R)

(2010) Vivekananda M. Vrudhula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists

(2010) Dmitry Zuev et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

(2010) Sriram Tyagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of potent, substituted carbazoles as selective androgen receptor modulators (SARMs)

(2010) Chris P. Miller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

(2010) Georg Schitter et al.   CHEMBIOCHEM

ITZ-1, a Client-Selective Hsp90 Inhibitor, Efficiently Induces Heat Shock Factor 1 Activation

(2010) Haruhide Kimura et al.   CHEMISTRY & BIOLOGY

Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines – Their potential as adenosine receptor ligands

(2010) B. Sirisha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Fluorous Photoaffinity Labels (F-PAL) and Their Application in V-ATPase Inhibition Studies

(2010) Nadja Burkard et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

(2010) Anna K. Renfrew et al.   INORGANIC CHEMISTRY

Surface and antimicrobial properties of semi-fluorinated quaternary ammonium thiol surfactants potentially usable for Self-Assembled Monolayers

(2010) Pascal Thebault et al.   JOURNAL OF FLUORINE CHEMISTRY

Extreme modulation properties of aromatic fluorine

(2010) Andrei A. Gakh et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis and Biochemical Characterization of a Series of 17α-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor α

(2010) Barbara Eignerová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2

(2010) George Kokotos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly fluorous zirconocene(IV) complexes and their catalytic applications in the polymerization of ethylene

(2010) Juan Cámpora et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains

(2010) Anna K. Renfrew et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

New cyclopalladated benzothiophenes: a catalyst precursor for the Suzuki coupling of deactivated aryl chlorides

(2010) Madavu Salian Subhas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors

(2010) V. V. Krutikova et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2

(2009) Alessandra Gianoncelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

(2009) Purakkattle Biju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists

(2009) Nareshkumar Jain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors

(2009) Francesca Olimpieri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

(2009) Nicolas Charrier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemistry, Physical Chemistry, and Uses of Molecular Fluorocarbon−Hydrocarbon Diblocks, Triblocks, and Related CompoundsUnique “Apolar” Components for Self-Assembled Colloid and Interface Engineering

(2009) Marie Pierre Krafft et al.   CHEMICAL REVIEWS

Highly fluorinated amphiphilic molecules and self-assemblies with biomedical potential

(2009) Jean G. Riess   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Click chemistry: Studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation – Theoretical and experimental validation

(2009) P. Mani Chandrika et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

(2009) Zohra Benfodda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular imaging of hypoxia with radiolabelled agents

(2009) Gilles Mees et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Fluorous-based small-molecule microarrays for protein, antibody and enzyme screening

(2009) Eun-Ho Song et al.   Future Medicinal Chemistry

Synthesis of Fluorinated Brassinosteroids Based on Alkene Cross-Metathesis and Preliminary Biological Assessment

(2009) Barbara Eignerová et al.   JOURNAL OF MEDICINAL CHEMISTRY

7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists

(2008) Puwen Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas

(2008) Kekeli Ekoue-Kovi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

(2008) Philip Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors: Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides—in vitro and in vivo studies

(2008) Jerapan Krungkrai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application

(2008) Christiane Contino-Pépin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

(2008) Lionel Massi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of symmetric and dissymetric bisperfluoroalkanesulfonylimides and evaluation of their inhibition on bovine carbonic anhydrase

(2008) Zohra Benfodda et al.   HETEROATOM CHEMISTRY

Polymerizable semi-fluorinated gemini surfactants designed for antimicrobial materials

(2008) Laurent Caillier et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

(2008) David B. Berkowitz et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY

Structure−Activity Relationship of Kahalalide F Synthetic Analogues

(2008) José C. Jiménez et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structural characterization of the C-6 fluoroalkylated pyrimidine derivatives

(2008) Svjetlana Krištafor et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and antimicrobial characterization of novel l-lysine gemini surfactants pended with reactive groups

(2008) Hong Tan et al.   TETRAHEDRON LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

Fluorous tolerance of the estrogen receptor alpha as probed by 11-polyfluoroalkylestradiol derivatives

(2007) Vangelis Agouridas et al.   STEROIDS