Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 6, Issue 5, Pages 416-418Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017809788681257
Keywords
Isoflavone; perfluoroalkylsulfonate; regioselectivity; HL-60
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Funding
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0526]
- Shanghai Municipal Natural Science Foundation [06ZR14001]
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Isoflavonoids containing a perfluoroalkylsulfonyloxy group were synthesized by perfluoroalkylsulfonylation of hydroxyisoflavones. The reaction showed high regioselectivity. Inhibitory effects of the synthesized isoflavones against proliferation of HL-60 and BEL-7402 cells were tested in vitro. Two isoflavones displayed strong inhibitory effect on HL-60 cells.
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