Synthesis of symmetric and dissymetric bisperfluoroalkanesulfonylimides and evaluation of their inhibition on bovine carbonic anhydrase

This study describes a synthesis of symmetric and dissymmetric bis[(perfluoroalkane)sulfonyl]imides by the reaction of the sodium salt of perfluoroalkanesulfonamide RFSO2NH-Na+ (RF = C4F9, C6F13, C8F17) with hexamethyldisilazane and perfluoroalkanesulfonyffluoride RIS02F (RF C4F9, C6F13, C8F17)- They are obtained, in two steps, in moderate overall yield. Moreover, this paper provides a study of their inhibition on bovine carbonic anhydrase. (c) 2008 Wiley Periodicals, Inc.