Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 19, Pages 5831-5834Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.07.126
Keywords
Anticancer activity; 2 '-Deoxyuridine; Perfluoroalkyltriazole; 1,3-Dipolar cycloaddition reaction
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Funding
- Korean government (MEST) [20090065415]
- KRIBB Research Initiative Program
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We have focused on the C5-modification of 2'-deoxyuridine with substituted heterocycles for bioactivity, such as antiviral or anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an anticancer drug candidate. (C) 2010 Elsevier Ltd. All rights reserved.
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