☆ 4.7 Article

Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Volume 46, Issue 8, Pages 3462-3468

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

DOI: 10.1016/j.ejmech.2011.05.011

Keywords

Pyrido[2,3-d]pyrimidine; Cyclisation; Propargylation; Perfluoroalkyl azides; Sharpless conditions; Anticancer activity

Categories

Chemistry, Medicinal

Funding

Council of Scientific and Industrial Research(CSIR), India

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Abstract

A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U-937, THP-1 and Colo205. The promising compounds 5b and Se have been identified. (C) 2011 Elsevier Masson SAS. All rights reserved.

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