Designing inhibitors of anthrax toxin

Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete

(2013) Kyoung Hwa Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection

(2013) Mahtab Moayeri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two anthrax cases with soft tissue infection, severe oedema and sepsis in Danish heroin users

(2013) Lene Russell et al.   BMC INFECTIOUS DISEASES

Cyclodextrin derivatives as anti-infectives

(2013) Vladimir A Karginov   CURRENT OPINION IN PHARMACOLOGY

Anthrax toxin-induced rupture of artificial lipid bilayer membranes

(2013) Brian J. Nablo et al.   JOURNAL OF CHEMICAL PHYSICS

Key tissue targets responsible for anthrax-toxin-induced lethality

(2013) Shihui Liu et al.   NATURE

Anthrax drug first antibacterial mAb to win approval

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Animal rule for drug approval creates a jungle of confusion

(2013) Elie Dolgin   NATURE MEDICINE

Inhibitors of Bacillus anthracis edema factor

(2013) Roland Seifert et al.   PHARMACOLOGY & THERAPEUTICS

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

(2013) Christoph Beitzinger et al.   PLoS One

Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis

(2013) S.-Y. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

(2013) E. J. Gillespie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

(2012) Guan-Sheng Jiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interactions of High-Affinity Cationic Blockers with the Translocation Pores of B. anthracis, C. botulinum, and C. perfringens Binary Toxins

(2012) Sergey M. Bezrukov et al.   BIOPHYSICAL JOURNAL

Obstructing Toxin Pathways by Targeted Pore Blockage

(2012) Ekaterina M. Nestorovich et al.   CHEMICAL REVIEWS

Novel Approaches to the Treatment of Systemic Anthrax

(2012) A. W. Artenstein et al.   CLINICAL INFECTIOUS DISEASES

A Novel Mechanism for Antibody-based Anthrax Toxin Neutralization

(2012) Adva Mechaly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a Comprehensive, Validated Pharmacophore Hypothesis for Anthrax Toxin Lethal Factor (LF) Inhibitors Using Genetic Algorithms, Pareto Scoring, and Structural Biology

(2012) Ting-Lan Chiu et al.   Journal of Chemical Information and Modeling

Small Molecule Inhibitors of Bacillus anthracis Protective Antigen Proteolytic Activation and Oligomerization

(2012) Alexander N. Wein et al.   JOURNAL OF MEDICINAL CHEMISTRY

A FRET-Based High Throughput Screening Assay to Identify Inhibitors of Anthrax Protective Antigen Binding to Capillary Morphogenesis Gene 2 Protein

(2012) Michael S. Rogers et al.   PLoS One

Ratcheting up protein translocation with anthrax toxin

(2012) Geoffrey K. Feld et al.   PROTEIN SCIENCE

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

(2012) Catherine H. Schein et al.   Toxins

Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

(2012) Élodie Laine et al.   Toxins

Noninvasive Imaging Technologies Reveal Edema Toxin as a Key Virulence Factor in Anthrax

(2011) Fabien Dumetz et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemical Dissection of Protein Translocation through the Anthrax Toxin Pore

(2011) Brad L. Pentelute et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Symmetry Requirements for Effective Blocking of Pore-Forming Toxins: Comparative Study with α-, β-, and γ-Cyclodextrin Derivatives

(2011) Konstantina Yannakopoulou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural basis of anthrax edema factor neutralization by a neutralizing antibody

(2011) Michelle Makiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure–activity relationships for the interactions of 2′- and 3′-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases

(2011) Cibele Pinto et al.   BIOCHEMICAL PHARMACOLOGY

Structure-Based Design of a Heptavalent Anthrax Toxin Inhibitor

(2011) Amit Joshi et al.   BIOMACROMOLECULES

Structure-based redesign of an edema toxin inhibitor

(2011) Deliang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antidotes to anthrax lethal factor intoxication. Part 2: Structural modifications leading to improved in vivo efficacy

(2011) Seongjin Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Molecule Inhibitors of Anthrax Toxin-induced Cytotoxicity Targeted Against Protective Antigen

(2011) Charles Rubert Pérez et al.   Chemical Biology & Drug Design

New Developments in Vaccines, Inhibitors of Anthrax Toxins, and Antibiotic Therapeutics for Bacillus anthracis

(2011) J. M. Beierlein et al.   CURRENT MEDICINAL CHEMISTRY

Mouse Monoclonal Antibodies to Anthrax Edema Factor Protect against Infection

(2011) Clinton E. Leysath et al.   INFECTION AND IMMUNITY

Charge Requirements for Proton Gradient-driven Translocation of Anthrax Toxin

(2011) Michael J. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins

(2011) Daniel Basilio et al.   JOURNAL OF GENERAL PHYSIOLOGY

A kinetic analysis of protein transport through the anthrax toxin channel

(2011) Daniel Basilio et al.   JOURNAL OF GENERAL PHYSIOLOGY

The unfolding story of anthrax toxin translocation

(2011) Katie L. Thoren et al.   MOLECULAR MICROBIOLOGY

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates

(2011) Hesham Taha et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Tumor Endothelium Marker-8 Based Decoys Exhibit Superiority over Capillary Morphogenesis Protein-2 Based Decoys as Anthrax Toxin Inhibitors

(2011) Chenguang Cai et al.   PLoS One

Tailored ß-Cyclodextrin Blocks the Translocation Pores of Binary Exotoxins from C. Botulinum and C. Perfringens and Protects Cells from Intoxication

(2011) Ekaterina M. Nestorovich et al.   PLoS One

Anthrax toxin protective antigen-Insights into molecular switching from prepore to pore

(2011) James G. Bann   PROTEIN SCIENCE

A Receptor-based Switch that Regulates Anthrax Toxin Pore Formation

(2011) Rosemarie M. Pilpa et al.   PLoS Pathogens

Monoclonal Antibody Therapies against Anthrax

(2011) Zhaochun Chen et al.   Toxins

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

(2010) Guan-Sheng Jiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Blockage of Anthrax PA63 Pore by a Multicharged High-Affinity Toxin Inhibitor

(2010) Ekaterina M. Nestorovich et al.   BIOPHYSICAL JOURNAL

Symmetry Complementarity-Guided Design of Anthrax Toxin Inhibitors Based on β-Cyclodextrin: Synthesis and Relative Activities of Face-Selective Functionalized Polycationic Clusters

(2010) Alejandro Díaz-Moscoso et al.   ChemMedChem

Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy

(2010) Lorna et al.   Frontiers in Bioscience-Landmark

Neutralizing Monoclonal Antibody to Edema Toxin and Its Effect on Murine Anthrax

(2010) L. Winterroth et al.   INFECTION AND IMMUNITY

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

(2010) Albert G. Remacle et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effects of Introducing a Single Charged Residue into the Phenylalanine Clamp of Multimeric Anthrax Protective Antigen

(2010) Blythe E. Janowiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current and Future Medical Approaches To Combat the Anthrax Threat

(2010) Dimitrios G. Bouzianas   JOURNAL OF MEDICINAL CHEMISTRY

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

(2010) E. Laine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterodimeric integrin complexes containing  1-integrin promote internalization and lethality of anthrax toxin

(2010) M. Martchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake

(2010) L. Abrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter-α Inhibitor Proteins

(2010) Steven M. Opal et al.   SHOCK

Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

(2010) Laurence Abrami et al.   PLoS Pathogens

Distinct interactions of 2′- and 3′-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor

(2009) Srividya Suryanarayana et al.   BIOCHEMICAL PHARMACOLOGY

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

(2009) Ping Jun Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigation of New Dominant-Negative Inhibitors of Anthrax Protective Antigen Mutants for Use in Therapy and Vaccination

(2009) S. Cao et al.   INFECTION AND IMMUNITY

Evidence for a Proton–Protein Symport Mechanism in the Anthrax Toxin Channel

(2009) Daniel Basilio et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes

(2009) Alexander F. Kintzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane translocation by anthrax toxin

(2009) R. John Collier   MOLECULAR ASPECTS OF MEDICINE

The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity

(2009) Fiorella Tonello et al.   MOLECULAR ASPECTS OF MEDICINE

The surface of Bacillus anthracis

(2009) Agnès Fouet   MOLECULAR ASPECTS OF MEDICINE

Cellular and systemic effects of anthrax lethal toxin and edema toxin

(2009) Mahtab Moayeri et al.   MOLECULAR ASPECTS OF MEDICINE

Isolation and Chimerization of a Highly Neutralizing Antibody Conferring Passive Protection against Lethal Bacillus anthracis Infection

(2009) Ronit Rosenfeld et al.   PLoS One

Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation

(2009) K. L. Thoren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding

(2009) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen

(2009) Blythe E. Janowiak et al.   PROTEIN SCIENCE

Medical countermeasures to protect humans from anthrax bioterrorism

(2009) Dimitrios G. Bouzianas   TRENDS IN MICROBIOLOGY

In Vivo Efficacy of  -Cyclodextrin Derivatives against Anthrax Lethal Toxin

(2008) M. Moayeri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel inhibitors of anthrax edema factor

(2008) Deliang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polyvalency: A promising strategy for drug design

(2008) David Vance et al.   BIOTECHNOLOGY AND BIOENGINEERING

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway

(2008) Katherine E. Wickliffe et al.   CELLULAR MICROBIOLOGY

Discovery and Development of Anthrax Lethal Factor Metalloproteinase Inhibitors

(2008) Benjamin Turk   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Modeling the activity of furin inhibitors using artificial neural network

(2008) Apilak Worachartcheewan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of homopolymers and copolymers containing an active ester of acrylic acid by RAFT: Scaffolds for controlling polyvalent ligand display

(2008) Kunal V. Gujraty et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Low Molecular Weight Inhibitors of the Protease Anthrax Lethal Factor

(2008) Georgios Spyroulias et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

(2008) H. M. Taha et al.   MOLECULAR PHARMACOLOGY

GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore

(2008) Hiroo Katayama et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation

(2008) J. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ratio of lethal and edema factors in rabbit systemic anthrax

(2008) Federica Dal Molin et al.   TOXICON