Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Cellular Interactions of the Cytolethal Distending Toxins fromEscherichia coliandHaemophilus ducreyi

(2013) Amandeep Gargi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Cytosolic clearance of replication-deficient mutants revealsFrancisella tularensisinteractions with the autophagic pathway

(2012) Audrey Chong et al.   Autophagy

The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments

(2012) Katia Cortese et al.   MOLECULAR BIOLOGY OF THE CELL

Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages

(2012) Kristina A. Hellmich et al.   PLoS One

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

O-Antigen-Deficient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafficking in Human Macrophages

(2011) Daniel L. Clemens et al.   INFECTION AND IMMUNITY

Role of Endosomes in Simian Virus 40 Entry and Infection

(2011) S. Engel et al.   JOURNAL OF VIROLOGY

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

The Biology of the Cytolethal Distending Toxins

(2011) Lina Guerra et al.   Toxins

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Cytolethal Distending Toxin Family Members Are Differentially Affected by Alterations in Host Glycans and Membrane Cholesterol

(2010) Aria Eshraghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

(2010) Paul G. Wahome et al.   TOXICON

Novel approaches in anti-arenaviral drug development

(2010) Andrew M. Lee et al.   VIROLOGY

Francisella tularensis Phagosomal Escape Does Not Require Acidification of the Phagosome

(2009) D. L. Clemens et al.   INFECTION AND IMMUNITY

Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b

(2009) Jill K. Terra et al.   JOURNAL OF IMMUNOLOGY

The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes

(2009) Alexander F. Kintzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Cellular and systemic effects of anthrax lethal toxin and edema toxin

(2009) Mahtab Moayeri et al.   MOLECULAR ASPECTS OF MEDICINE

Anthrax Lethal Toxin Induced Lysosomal Membrane Permeabilization and Cytosolic Cathepsin Release Is Nlrp1b/Nalp1b-Dependent

(2009) Kathleen M. Averette et al.   PLoS One

Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest

(2009) S. F. Emonet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

The Early Phagosomal Stage of Francisella tularensis Determines Optimal Phagosomal Escape and Francisella Pathogenicity Island Protein Expression

(2008) A. Chong et al.   INFECTION AND IMMUNITY

Role of endocytosis and cathepsin-mediated activation in Nipah virus entry

(2008) Sandra Diederich et al.   VIROLOGY