Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

Strategies to overexpress enterotoxigenic Escherichia coli (ETEC) colonization factors for the construction of oral whole-cell inactivated ETEC vaccine candidates

(2012) Joshua Tobias et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence

(2012) Xiaogang Wang et al.   CELLULAR MICROBIOLOGY

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Binding Affinity Prediction for Ligands and Receptors Forming Tautomers and Ionization Species: Inhibition of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2)

(2012) Senthil Natesan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor

(2012) Hae-Chul Park et al.   MICROBIAL PATHOGENESIS

Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

(2012) Élodie Laine et al.   Toxins

Subsite specificity of anthrax lethal factor and its implications for inhibitor development

(2011) Feng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-based redesign of an edema toxin inhibitor

(2011) Deliang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates

(2011) Hesham Taha et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hemodynamic Effects of Anthrax Toxins in the Rabbit Model and the Cardiac Pathology Induced by Lethal Toxin

(2011) William S. Lawrence et al.   Toxins

Testing the Efficacy and Toxicity of Adenylyl Cyclase Inhibitors against Enteric Pathogens Using In Vitro and In Vivo Models of Infection

(2010) S. T. Moen et al.   INFECTION AND IMMUNITY

A Comparative Genomic Analysis of Diverse Clonal Types of EnterotoxigenicEscherichia coliReveals Pathovar-Specific Conservation

(2010) Jason W. Sahl et al.   INFECTION AND IMMUNITY

Anthrax Lethal and Edema Toxins Produce Different Patterns of Cardiovascular and Renal Dysfunction and Synergistically Decrease Survival in Canines

(2010) Daniel A. Sweeney et al.   JOURNAL OF INFECTIOUS DISEASES

Drawing the PDB: Protein−Ligand Complexes in Two Dimensions

(2010) Katrin Stierand et al.   ACS Medicinal Chemistry Letters

Computational selection of inhibitors of Aβ aggregation and neuronal toxicity

(2009) Deliang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of Linear Epitopes inBacillus anthracisProtective Antigen Bound by Neutralizing Antibodies

(2009) Nareen Abboud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Raxibacumab for the Treatment of Inhalational Anthrax

(2009) Thi-Sau Migone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel inhibitors of anthrax edema factor

(2008) Deliang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influence of Host Interleukin-10 Polymorphisms on Development of Traveler's Diarrhea Due to Heat-Labile Enterotoxin-Producing Escherichia coli in Travelers from the United States Who Are Visiting Mexico

(2008) J. Flores et al.   Clinical and Vaccine Immunology