Ligand–receptor interaction platforms and their applications for drug discovery

High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition

(2012) Ann M. Ferrie et al.   APPLIED PHYSICS LETTERS

Can biochemistry drive drug discovery beyond simple potency measurements?

(2012) Patrick Chène   DRUG DISCOVERY TODAY

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

(2012) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

(2012) Kazuko Haga et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Structure and dynamics of the M3 muscarinic acetylcholine receptor

(2012) Andrew C. Kruse et al.   NATURE

Label-Free Phenotypic Profiling Identified D-Luciferin as a GPR35 Agonist

(2012) Haibei Hu et al.   PLoS One

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4

(2012) M. M. Mysinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Application of Optical Biosensors in Small-Molecule Screening Activities

(2012) Stefan Geschwindner et al.   SENSORS

Determination of drug–receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance

(2012) Georges Vauquelin   MedChemComm

Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target

(2012) Duncan C. Miller et al.   MedChemComm

Label-Free Detection of G Protein–SNARE Interactions and Screening for Small Molecule Modulators

(2011) Christopher A. Wells et al.   ACS Chemical Neuroscience

Microfluidic resonant waveguide grating biosensor system for whole cell sensing

(2011) Natalya Zaytseva et al.   APPLIED PHYSICS LETTERS

Dynamic Mass Redistribution as a Means to Measure and Differentiate Signaling via Opioid and Cannabinoid Receptors

(2011) Ellen E. Codd et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Dynamic Mass Redistribution Assays Decode Surface Influence on Signaling of Endogenous Purinergic P2Y Receptors

(2011) Elizabeth Tran et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Thermal Denaturation Assays in Chemical Biology

(2011) Guillermo Senisterra et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Kinetic efficiency: the missing metric for enhancing compound quality?

(2011) Geoffrey A. Holdgate et al.   DRUG DISCOVERY TODAY

Learning lessons from drugs that have recently entered the market

(2011) Simon J. Teague   DRUG DISCOVERY TODAY

Target–drug interactions: first principles and their application to drug discovery

(2011) Sara Núñez et al.   DRUG DISCOVERY TODAY

The development of label-free cellular assays for drug discovery

(2011) Ye Fang   Expert Opinion on Drug Discovery

Tyrphostin analogs are GPR35 agonists

(2011) Huayun Deng et al.   FEBS LETTERS

Label-free optical biosensor with microfluidics for sensing ligand-directed functional selectivity on trafficking of thrombin receptor

(2011) Vasiliy Goral et al.   FEBS LETTERS

Biosensor-based small molecule fragment screening with biolayer interferometry

(2011) Charles A. Wartchow et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Label-free quantification of membrane-ligand interactions using backscattering interferometry

(2011) Michael M Baksh et al.   NATURE BIOTECHNOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

(2011) Florence Verrier et al.   Nature Chemical Biology

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

(2011) Jens Carlsson et al.   Nature Chemical Biology

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Agonist-Directed Desensitization of the β2-Adrenergic Receptor

(2011) Vasiliy Goral et al.   PLoS One

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

(2011) María-Isabel Rocha-Gaso et al.   SENSORS

Screening for GPCR Ligands Using Surface Plasmon Resonance

(2011) Iva Navratilova et al.   ACS Medicinal Chemistry Letters

Whispering gallery microresonators for second harmonic light generation from a low number of small molecules

(2011) J.L. Dominguez-Juarez et al.   Nature Communications

Screening Kinase Inhibitors with a Microarray-Based Fluorescent and Resonance Light Scattering Assay

(2010) Tao Li et al.   ANALYTICAL CHEMISTRY

Resonant waveguide grating imager for live cell sensing

(2010) Ann M. Ferrie et al.   APPLIED PHYSICS LETTERS

The Chemical Basis of Pharmacology

(2010) Michael J. Keiser et al.   BIOCHEMISTRY

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

(2010) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Being mindful of seven-transmembrane receptor ‘guests’ when assessing agonist selectivity

(2010) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-throughput screening for modulators of protein–protein interactions: use of photonic crystal biosensors and complementary technologies

(2010) James T. Heeres et al.   CHEMICAL SOCIETY REVIEWS

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Higher throughput calorimetry: opportunities, approaches and challenges

(2010) Francisco E Torres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation

(2010) Cele Abad-Zapatero et al.   DRUG DISCOVERY TODAY

Thermodynamics guided lead discovery and optimization

(2010) György G. Ferenczy et al.   DRUG DISCOVERY TODAY

Free-solution interaction assay of carbonic anhydrase to its inhibitors using back-scattering interferometry

(2010) Ereny F. Morcos et al.   ELECTROPHORESIS

The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

(2010) Robert A Copeland   Expert Opinion on Drug Discovery

Fluorescence polarization assays in small molecule screening

(2010) Wendy A Lea et al.   Expert Opinion on Drug Discovery

Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs

(2010) Rumin Zhang et al.   Expert Opinion on Drug Discovery

Predicting Polypharmacology by Binding Site Similarity: From Kinases to the Protein Universe

(2010) Francesca Milletti et al.   Journal of Chemical Information and Modeling

Structure-Based Discovery of A2AAdenosine Receptor Ligands

(2010) Jens Carlsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Theory and Applications of Surface Plasmon Resonance, Resonant Mirror, Resonant Waveguide Grating, and Dual Polarization Interferometry Biosensors

(2010) Hikmat N. Daghestani et al.   SENSORS

Free-Solution Label-Free Detection of α-Crystallin Chaperone Interactions by Back-Scattering Interferometry

(2009) Joey C. Latham et al.   ANALYTICAL CHEMISTRY

Surface plasmon resonance imaging for affinity-based biosensors

(2009) Simona Scarano et al.   BIOSENSORS & BIOELECTRONICS

Label-Free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization

(2009) Joy Concepcion et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

Simple Size-Independent Measure of Ligand Efficiency

(2009) J. Willem M. Nissink   Journal of Chemical Information and Modeling

An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators

(2009) Anna Kebig et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Real-time quantitation of viral replication and inhibitor potency using a label-free optical biosensor

(2009) Róisín M. Owens et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Proteins and proteomics: life on the surface

(2009) Nathan Blow   NATURE METHODS

Structure-based discovery of  2-adrenergic receptor ligands

(2009) P. Kolb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface acoustic wave biosensors: a review

(2008) Kerstin Länge et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Detergent screening of a G-protein-coupled receptor using serial and array biosensor technologies

(2008) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Scintillation Proximity Assays in High-Throughput Screening

(2008) J. Fraser Glickman et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Ligand efficiency and fragment-based drug discovery

(2008) Scott D. Bembenek et al.   DRUG DISCOVERY TODAY

The challenge of selecting protein kinase assays for lead discovery optimization

(2008) Haiching Ma et al.   Expert Opinion on Drug Discovery

Label-free optical biosensor for ligand-directed functional selectivity acting on β2adrenoceptor in living cells

(2008) Ye Fang et al.   FEBS LETTERS

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαiand Downstream Signaling Cascade Activation

(2008) Ralf Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

(2008) Charles H. Reynolds et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging

(2008) Christopher Lausted et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Whispering-gallery-mode biosensing: label-free detection down to single molecules

(2008) Frank Vollmer et al.   NATURE METHODS

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY

Single virus detection from the reactive shift of a whispering-gallery mode

(2008) F. Vollmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE