4.6 Article

High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition

Journal

APPLIED PHYSICS LETTERS
Volume 100, Issue 22, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.4723691

Keywords

-

Ask authors/readers for more resources

We report on a spatially resolved resonant waveguide grating imager for cell cluster analysis under physiological condition. Compared to results obtained under ambient condition, the activation of a receptor resulted in a similar biosensor signature but with faster kinetics and greater amplitude. The imager further detected receptor signaling in and movements of single cells within small cell clusters. This opens possibility to investigate the heterogeneity and robustness of receptor signaling from single cells to cell systems. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4723691]

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Chemistry, Analytical

Probing Biochemical Mechanisms of Action of Muscarinic M3 Receptor Antagonists with Label-Free Whole Cell Assays

Huayun Deng, Chaoming Wang, Ming Su, Ye Fang

ANALYTICAL CHEMISTRY (2012)

Article Biochemical Research Methods

Dynamic Mass Redistribution Assays Decode Surface Influence on Signaling of Endogenous Purinergic P2Y Receptors

Elizabeth Tran, Haiyan Sun, Ye Fang

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2012)

Article Chemistry, Medicinal

Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists

Huayun Deng, Jieyu Hu, Haibei Hu, Mingqian He, Ye Fang

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Pharmacology & Pharmacy

Ligand-receptor interaction platforms and their applications for drug discovery

Ye Fang

EXPERT OPINION ON DRUG DISCOVERY (2012)

Article Chemistry, Medicinal

Discovery of 2-(4-Methylfuran-2(5H)-ylidene)malononitrile and Thieno[3,2-b]thiophene-2-carboxylic Acid Derivatives as G Protein-Coupled Receptor 35 (GPR35) Agonists

Huayun Deng, Haibei Hu, Mingqian He, Jieyu Hu, Weijun Niu, Ann M. Ferrie, Ye Fang

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

Florence Verrier, Songon An, Ann M. Ferrie, Haiyan Sun, Minjoung Kyoung, Huayun Deng, Ye Fang, Stephen J. Benkovic

NATURE CHEMICAL BIOLOGY (2011)

Article Pharmacology & Pharmacy

Aspirin metabolites are GPR35 agonists

Huayun Deng, Ye Fang

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2012)

Article Pharmacology & Pharmacy

Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists

Huayun Deng, Ye Fang

PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Discovery of nitrophenols as GPR35 agonists

Huayun Deng, Ye Fang

MEDCHEMCOMM (2012)

Article Chemistry, Medicinal

Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues

Huayun Deng, Ye Fang

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Chemistry, Medicinal

Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

Huayun Deng, Haibei Hu, Shizhang Ling, Ann M. Ferrie, Ye Fang

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Multidisciplinary Sciences

Multiple tyrosine metabolites are GPR35 agonists

Huayun Deng, Haibei Hu, Ye Fang

SCIENTIFIC REPORTS (2012)

Article Pharmacology & Pharmacy

Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery

Ye Fang

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2013)

Article Biochemical Research Methods

Dynamic Mass Redistribution Assay Decodes Differentiation of a Neural Progenitor Stem Cell

Sadashiva Pai, Florence Verrier, Haiyan Sun, Haibei Hu, Ann M. Ferrie, Azita Eshraghi, Ye Fang

JOURNAL OF BIOMOLECULAR SCREENING (2012)

No Data Available