Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity

(2010) Ron Diskin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

(2009) Denis Sohy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?

(2009) Marta Filizola   LIFE SCIENCES

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

(2009) M. Pancera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

The chemokine receptors CXCR4 and CXCR3 in cancer

(2009) Amy M. Fulton   Current Oncology Reports

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD

Modulation of chemokine receptor activity through dimerization and crosstalk

(2008) C. L. Salanga et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy

(2008) Jinhai Wang et al.   DRUG DISCOVERY TODAY

Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation

(2008) Oscar M. Pello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo

(2008) Gebhard Thoma et al.   JOURNAL OF MEDICINAL CHEMISTRY

New insights on the role of CXCR4 in cancer metastasis

(2008) A Zlotnik   JOURNAL OF PATHOLOGY

Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026

(2008) G. Moncunill et al.   MOLECULAR PHARMACOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

(2008) Nilgun Isik et al.   PLoS One

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

(2007) Christopher B. Roth et al.   JOURNAL OF MOLECULAR BIOLOGY