Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs

Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput Screening of Cytochrome P450 3A4 Inhibition

(2010) Nobuo Sekiguchi et al.   Drug Metabolism and Pharmacokinetics

The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

(2010) Robert A Copeland   Expert Opinion on Drug Discovery

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

(2009) Johan Gabrielsson et al.   DRUG DISCOVERY TODAY

Beyond Thermodynamics: Drug Binding Kinetics Could Influence Epidermal Growth Factor Signaling

(2009) Mayank Goyal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Signal transduction profiling using label-free biosensors

(2009) Matthew A. Cooper   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

(2009) Terry P. Kenakin   NATURE REVIEWS DRUG DISCOVERY

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Target site occupancy: Emerging generalizations from clinical and preclinical studies

(2009) Sarah Grimwood et al.   PHARMACOLOGY & THERAPEUTICS

Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50shift approach facilitateskinactassay design

(2009) E. S. Perloff et al.   XENOBIOTICA

A global benchmark study using affinity-based biosensors

(2008) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods

(2008) Kenneth H. Grime et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Some features of the kinetics and equilibrium of drug binding to plasma proteins

(2008) Leonid M Berezhkovskiy   Expert Opinion on Drug Metabolism & Toxicology

Impact of plasma-protein binding on receptor occupancy: An analytical description

(2008) Lambertus A. Peletier et al.   JOURNAL OF THEORETICAL BIOLOGY