Toxoplasma gondii Development of Its Replicative Niche: in Its Host Cell and Beyond

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

Dendritic Cells Expressing Plasmacytoid Marker PDCA-1 Are Trojan Horses during Toxoplasma gondii Infection

(2014) A. L. Bierly et al.   JOURNAL OF IMMUNOLOGY

Programmed necrosis in microbial pathogenesis

(2014) Haripriya Sridharan et al.   TRENDS IN MICROBIOLOGY

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasmaexports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression

(2013) Alexandre Bougdour et al.   CELLULAR MICROBIOLOGY

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production

(2013) Michael J. Brumlik et al.   EXPERIMENTAL PARASITOLOGY

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

(2013) Emily E. Rosowski et al.   INFECTION AND IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15

(2013) L. Gov et al.   mBio

Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

(2013) Zhu-Hong Li et al.   PLoS Pathogens

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite

(2013) Luis Muniz-Feliciano et al.   PLoS Pathogens

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

Virulence factors of Toxoplasma gondii

(2012) Jean François Dubremetz et al.   MICROBES AND INFECTION

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

Toxoplasma Co-opts Host Cells It Does Not Invade

(2012) Anita A. Koshy et al.   PLoS Pathogens

Impaired Chromatin Remodelling at STAT1-Regulated Promoters Leads to Global Unresponsiveness of Toxoplasma gondii-Infected Macrophages to IFN-γ

(2012) Christine Lang et al.   PLoS Pathogens

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii

(2011) Ryan J. Whitmarsh et al.   Cell Host & Microbe

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii

(2011) Andrea Stutz et al.   IMMUNOBIOLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

(2011) Sethu C. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It

(2011) Sebastian Virreira Winter et al.   PLoS One

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma gondii Rhoptry Kinase ROP16 Activates STAT3 and STAT6 Resulting in Cytokine Inhibition and Arginase-1-Dependent Growth Control

(2011) Barbara A. Butcher et al.   PLoS Pathogens

The Differential Effect of Toxoplasma Gondii Infection on the Stability of BCL2-Family Members Involves Multiple Activities

(2011) John Cherrington Carmen et al.   Frontiers in Microbiology

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells

(2010) William H. Witola et al.   INFECTION AND IMMUNITY

Toxoplasma gondiiActivates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling

(2010) Mandi Wiley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ToxoplasmaRhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6

(2010) Yi-Ching Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages

(2010) M. P. Lees et al.   JOURNAL OF IMMUNOLOGY

Population biology of Toxoplasma gondii: what's out and where did they come from

(2010) JP Dubey et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages

(2010) Gladys Corrêa et al.   MICROBES AND INFECTION

Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions

(2010) Anita A Koshy et al.   NATURE METHODS

Aldolase Is Essential for Energy Production and Bridging Adhesin-Actin Cytoskeletal Interactions during Parasite Invasion of Host Cells

(2009) G. Lucas Starnes et al.   Cell Host & Microbe

Forward Genetics inToxoplasma gondiiReveals a Family of Rhoptry Kinases That Mediates Pathogenesis

(2009) L. David Sibley et al.   EUKARYOTIC CELL

Host Cell P-glycoprotein Is Essential for Cholesterol Uptake and Replication ofToxoplasma gondii

(2009) Iveta Bottova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage

(2009) Hye-Jin Ahn et al.   PARASITOLOGY RESEARCH

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

(2009) M. Blume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY

Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii

(2008) Tobias Fleige et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Induction of mitotic S-phase of host and neighboring cells by Toxoplasma gondii enhances parasite invasion

(2008) Mark D. Lavine et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Host Cell Egress and Invasion Induce Marked Relocations of Glycolytic Enzymes in Toxoplasma gondii Tachyzoites

(2008) Sebastien Pomel et al.   PLoS Pathogens

Kiss and spit: the dual roles of Toxoplasma rhoptries

(2007) John C. Boothroyd et al.   NATURE REVIEWS MICROBIOLOGY