Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Nonenzymatic Rubylation and Ubiquitination of Proteins for Structural and Functional Studies

(2014) Rajesh K. Singh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

(2014) Daniel C. Scott et al.   CELL

Atomistic Autophagy: The Structures of Cellular Self-Digestion

(2014) James H. Hurley et al.   CELL

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair

(2014) Tingting Li et al.   JOURNAL OF CELL SCIENCE

Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility

(2014) X. Renaudin et al.   JOURNAL OF CELL SCIENCE

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis

(2014) Hua Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

(2014) Lihui Li et al.   JNCI-Journal of the National Cancer Institute

E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation

(2014) Anand Thirunavukarasou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways

(2014) K. Garcia et al.   MOLECULAR CANCER THERAPEUTICS

Crystal structure of the human COP9 signalosome

(2014) Gondichatnahalli M. Lingaraju et al.   NATURE

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells

(2014) G. Wei Xu et al.   PLoS One

Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer

(2014) Melissa Birol et al.   PLoS One

Suppression of tumor angiogenesis by targeting the protein neddylation pathway

(2014) W-T Yao et al.   Cell Death & Disease

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

Nucleolar control of p53: a cellular Achilles’ heel and a target for cancer therapy

(2013) Nikolina Vlatković et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cullin-RING Ligases as Attractive Anti-cancer Targets

(2013) Yongchao Zhao et al.   CURRENT PHARMACEUTICAL DESIGN

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

(2013) Ian R Kelsall et al.   EMBO JOURNAL

Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924

(2013) A. A. Jazaeri et al.   MOLECULAR CANCER THERAPEUTICS

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

(2013) Wei Zuo et al.   MOLECULAR CELL

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

Brap2 Regulates Temporal Control of NF-κB Localization Mediated by Inflammatory Response

(2013) Osamu Takashima et al.   PLoS One

Myeloma Overexpressed 2 (Myeov2) Regulates L11 Subnuclear Localization through Nedd8 Modification

(2013) Manato Ebina et al.   PLoS One

CSN- and CAND1-dependent remodelling of the budding yeast SCF complex

(2013) Aleksandra Zemla et al.   Nature Communications

CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire

(2013) Shuangding Wu et al.   Nature Communications

Protective autophagy induced byRBX1/ROC1knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis

(2012) Dongqin Yang et al.   Autophagy

Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells

(2012) Zhongguang Luo et al.   Autophagy

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation

(2012) Susanne Bandau et al.   BMC BIOLOGY

Cullin-3 protein expression levels correlate with breast cancer progression

(2012) Kelly K. Haagenson et al.   CANCER BIOLOGY & THERAPY

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) Michael A. Milhollen et al.   CANCER CELL

The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

(2012) Z. Luo et al.   CANCER RESEARCH

Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) J. L. Blank et al.   CANCER RESEARCH

Stress, specificity and the NEDD8 proteome

(2012) David P. Lane   CELL CYCLE

The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions

(2012) Orsolya Leidecker et al.   CELL CYCLE

NEDDylation regulates E2F-1-dependent transcription

(2012) Sarah J Loftus et al.   EMBO REPORTS

X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7

(2012) Taiki Nagano et al.   FEBS LETTERS

Targeting neddylation in cancer therapy

(2012) Kristal Duncan et al.   Future Oncology

Regulation of parkin and PINK1 by neddylation

(2012) Y. S. Choo et al.   HUMAN MOLECULAR GENETICS

NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway

(2012) Roland Hjerpe et al.   JOURNAL OF MOLECULAR BIOLOGY

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

(2012) Ji Won Um et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Recognition and Cleavage of Related to Ubiquitin 1 (Rub1) and Rub1-Ubiquitin Chains by Components of the Ubiquitin-Proteasome System

(2012) Rajesh K. Singh et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

(2012) Y. Kee et al.   MOLECULAR CANCER RESEARCH

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

(2012) Willem den Besten et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14

(2012) J Zhang et al.   ONCOGENE

NEDDylation controls the target specificity of E2F1 and apoptosis induction

(2012) I Aoki et al.   ONCOGENE

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

(2012) Dong Yang et al.   PLoS One

Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to Ischemia

(2012) Yang-ja Lee et al.   PLoS One

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

Structural Basis for a Reciprocal Regulation between SCF and CSN

(2012) Radoslav I. Enchev et al.   Cell Reports

A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924

(2012) Julia I. Toth et al.   Cell Reports

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

(2011) Roland Hjerpe et al.   BIOCHEMICAL JOURNAL

NEDD8 Pathways in Cancer, Sine Quibus Non

(2011) Ian R. Watson et al.   CANCER CELL

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage

(2011) A. K. Biswas et al.   CANCER RESEARCH

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

(2011) Yu Ye et al.   EMBO REPORTS

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer

(2011) Meng Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells

(2011) L. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

The TFIIH Subunit Tfb3 Regulates Cullin Neddylation

(2011) Gwenaël Rabut et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Structural basis for the subunit assembly of the anaphase-promoting complex

(2011) Anne Schreiber et al.   NATURE

Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner

(2011) B Mahata et al.   ONCOGENE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

Biochemical and cellular effects of inhibiting Nedd8 conjugation

(2010) Yee Chin Leck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia

(2010) R. T. Swords et al.   BLOOD

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

Specific inhibition of Mdm2-mediated neddylation by Tip60

(2010) Christoph Dohmesen et al.   CELL CYCLE

Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases

(2010) Meike Broemer et al.   MOLECULAR CELL

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways

(2010) G Liu et al.   ONCOGENE

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of cell growth by the SCF and APC/C ubiquitin ligases

(2009) Jeffrey R Skaar et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Degradation of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex

(2009) Yoshitaka Sato et al.   PLoS Pathogens

Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8

(2008) Mi-Ra Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Ribosomal proteins are targets for the NEDD8 pathway

(2008) Dimitris P Xirodimas et al.   EMBO REPORTS

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

NEDD8 acts as a ‘molecular switch’ defining the functional selectivity of VHL

(2008) Ryan C Russell et al.   EMBO REPORTS

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Parkin as a tumor suppressor gene for hepatocellular carcinoma

(2008) M Fujiwara et al.   ONCOGENE