Function, Genetic Polymorphism, and Transcriptional Regulation of Human UDP-glucuronosyltransferase (UGT) 1A1

Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors

(2012) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice

(2012) Shujuan Chen et al.   HEPATOLOGY

MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

(2012) Ryota Shizu et al.   PLoS One

Bilirubin Dependence on UGT1A1 Polymorphisms, Hemoglobin, Fasting Time and Body Mass Index

(2011) Carina Rodrigues et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans

(2011) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression

(2011) Rakesh Kundu et al.   BIOCHEMICAL PHARMACOLOGY

Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-κB Leads to Hyperbilirubinemia

(2011) Ryoichi Fujiwara et al.   GASTROENTEROLOGY

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

(2011) Makoto Osabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive activity and ligand-dependent activation of the nuclear receptor CAR-insights from molecular dynamics simulations

(2011) Björn Windshügel et al.   JOURNAL OF MOLECULAR RECOGNITION

Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases

(2011) Nina Sneitz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

FXR and PXR: Potential therapeutic targets in cholestasis

(2011) Johan W. Jonker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Post-translational modification of pregnane x receptor

(2011) Jeff L. Staudinger et al.   PHARMACOLOGICAL RESEARCH

Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver

(2011) Tatsuya Sueyoshi et al.   PLoS One

Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells

(2010) Anne-Sophie Belanger et al.   BMC MOLECULAR BIOLOGY

Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors

(2010) J. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Activation of xenobiotic receptors: driving into the nucleus

(2010) Haishan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10

(2010) Sandra Kalthoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Oncostatin M on Uridine Diphosphate-5′-Glucuronosyltransferase 1A1 through Cross Talk with Constitutive Androstane Receptor

(2010) Hisashi Masuyama et al.   MOLECULAR ENDOCRINOLOGY

Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli

(2010) Yoshiaki FUJII-KURIYAMA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

(2010) C. J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Induction of UGT1A1 and CYP2B6 by an Antimitogenic Factor in HepG2 Cells Is Mediated through Suppression of Cyclin-Dependent Kinase 2 Activity: Cell Cycle-Dependent Expression

(2009) J. Sugatani et al.   DRUG METABOLISM AND DISPOSITION

A Phosphomimetic Mutation at Threonine-57 Abolishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Receptor

(2009) S. R. Pondugula et al.   DRUG METABOLISM AND DISPOSITION

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

(2009) H. Li et al.   DRUG METABOLISM AND DISPOSITION

The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors

(2009) Peter I. Mackenzie et al.   DRUG METABOLISM REVIEWS

Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review

(2009) Glenn E Palomaki et al.   GENETICS IN MEDICINE

Cyclic AMP-dependent Protein Kinase Signaling Modulates Pregnane x Receptor Activity in a Species-specific Manner

(2009) Kristin Lichti-Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

(2009) Shingo Mutoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systematic Analysis of Predicted Phosphorylation Sites within the Human Pregnane X Receptor Protein

(2009) K. Lichti-Kaiser et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dependence on the Microtubule Network and 90-kDa Heat Shock Protein of Phenobarbital-Induced Nuclear Translocation of the Rat Constitutive Androstane Receptor

(2009) Y. Kanno et al.   MOLECULAR PHARMACOLOGY

Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation

(2008) Makoto Osabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediatedCYP3A4Gene Expression in HepG2 Liver Carcinoma Cells

(2008) Wenwei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPP1R16A, The Membrane Subunit of Protein Phosphatase 1 , Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor

(2008) T. Sueyoshi et al.   MOLECULAR PHARMACOLOGY

12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid [12(R)-HETE], an Arachidonic Acid Derivative, Is an Activator of the Aryl Hydrocarbon Receptor

(2008) Christopher. R. Chiaro et al.   MOLECULAR PHARMACOLOGY

Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter

(2008) Junko Sugatani et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY