Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes

Increased oxidative stress and the apoptosis of regulatory T cells in obese mice but not resistant mice in response to a high-fat diet

(2014) Bin Wang et al.   CELLULAR IMMUNOLOGY

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

Current issues in the identification and treatment of metabolically healthy but obese individuals

(2014) G. Plourde et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

(2013) Nicolas J. Pillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Linking the gut microbiota to human health

(2013) Virginia Robles Alonso et al.   BRITISH JOURNAL OF NUTRITION

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Can inflammatory status define metabolic health?

(2013) Antony D. Karelis et al.   Nature Reviews Endocrinology

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Microbial Reprogramming Inhibits Western Diet-Associated Obesity

(2013) Theofilos Poutahidis et al.   PLoS One

Acute peripheral administration of synthetic human GLP-1 (7–36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state?

(2013) Christina Daousi et al.   REGULATORY PEPTIDES

The immune system's involvement in obesity-driven type 2 diabetes

(2013) Chengyi Jenny Shu et al.   SEMINARS IN IMMUNOLOGY

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

(2013) Triantafyllos Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity

(2012) F. A. Duca et al.   BRITISH JOURNAL OF NUTRITION

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

(2012) Ana Paula Boroni Moreira et al.   BRITISH JOURNAL OF NUTRITION

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

(2012) Nicolas J Pillon et al.   Cell Communication and Signaling

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

(2012) Y.-S. Lee et al.   DIABETOLOGIA

Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors

(2012) F A Duca et al.   INTERNATIONAL JOURNAL OF OBESITY

An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice

(2012) Na Fei et al.   ISME Journal

Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin

(2012) M K Piya et al.   JOURNAL OF ENDOCRINOLOGY

CD64 Expression Distinguishes Monocyte-Derived and Conventional Dendritic Cells and Reveals Their Distinct Role during Intramuscular Immunization

(2012) C. Langlet et al.   JOURNAL OF IMMUNOLOGY

Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation

(2012) Rasheed Ahmad et al.   Journal of Inflammation-London

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Dietary oxidizedn-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells

(2012) Manar Awada et al.   JOURNAL OF LIPID RESEARCH

The gut microbiota, obesity and insulin resistance

(2012) Jian Shen et al.   MOLECULAR ASPECTS OF MEDICINE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Potential mechanisms for the emerging link between obesity and increased intestinal permeability

(2012) Tatiana F.S. Teixeira et al.   NUTRITION RESEARCH

Impaired protein metabolism: interlinks between obesity, insulin resistance and inflammation

(2012) C. Guillet et al.   Obesity Reviews

Towards an integrative approach to understanding the role of chemerin in human health and disease

(2012) J. L. Rourke et al.   Obesity Reviews

Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

(2012) Jane M.M. Natividad et al.   PHARMACOLOGICAL RESEARCH

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

(2012) Yan Y. Lam et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Obesity, inflammation and the immune system

(2012) Fátima Pérez de Heredia et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier

(2012) G.W. Moran et al.   REGULATORY PEPTIDES

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

(2011) Charlotte J. Green et al.   BIOCHEMICAL JOURNAL

Nutrient-induced inflammation in the intestine

(2011) Yong Ji et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes

(2011) P. J. Pussinen et al.   DIABETES CARE

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease

(2011) Pamela J Hornby et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Innate immune signaling in defense against intestinal microbes

(2011) Melissa A. Kinnebrew et al.   IMMUNOLOGICAL REVIEWS

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals

(2011) Caroline M Hodin et al.   JOURNAL OF PATHOLOGY

Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse

(2011) Donna M. Daly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gut microbiota, epithelial function and derangements in obesity

(2011) Helen E. Raybould   JOURNAL OF PHYSIOLOGY-LONDON

The effects of ghrelin on inflammation and the immune system

(2011) Dolgor Baatar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuropeptides as Pleiotropic Modulators of the Immune Response

(2011) Luciana Souza-Moreira et al.   NEUROENDOCRINOLOGY

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

(2011) H. James Harwood   NEUROPHARMACOLOGY

Effects of dietary fat on appetite and energy intake in health and obesity — Oral and gastrointestinal sensory contributions

(2011) Tanya J. Little et al.   PHYSIOLOGY & BEHAVIOR

Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation

(2011) Diana L. Williams et al.   PHYSIOLOGY & BEHAVIOR

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host–microbiota homeostasis

(2011) Takeshi Tanoue et al.   SEMINARS IN IMMUNOLOGY

Relationships between body mass index and short-circuit current in human duodenal and colonic mucosal biopsies

(2010) P. S. Osbak et al.   Acta Physiologica

Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis

(2010) Swaroop Pendyala et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cholecystokinin/Cholecystokinin-1 Receptor-Mediated Peripheral Activation of the Afferent Vagus by Enteral Nutrients Attenuates Inflammation in Rats

(2010) Tim Lubbers et al.   ANNALS OF SURGERY

Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

(2010) A. Santacruz et al.   BRITISH JOURNAL OF NUTRITION

Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats*

(2010) Rongqian Wu et al.   CRITICAL CARE MEDICINE

Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes

(2010) Henrike Sell et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese

(2010) L. Sun et al.   DIABETES CARE

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3

(2010) R. Deopurkar et al.   DIABETES CARE

A Western Diet Increases Serotonin Availability in Rat Small Intestine

(2010) R. L. Bertrand et al.   ENDOCRINOLOGY

Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota

(2010) M. S. Malo et al.   GUT

Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota

(2010) Renu Sharma et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

(2010) Takuya Suzuki et al.   Nutrition & Metabolism

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

(2010) Shengli Ding et al.   PLoS One

Epithelial crosstalk at the microbiota-mucosal interface

(2010) J. M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk

(2010) Paul Trayhurn et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment

(2009) Ying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action

(2009) Vijayalakshmi Varma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

(2009) Patrice Cani et al.   CURRENT PHARMACEUTICAL DESIGN

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

(2009) N. N. Mehta et al.   DIABETES

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal: Implications for insulin resistance

(2009) H. Ghanim et al.   DIABETES CARE

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4 Ligands in 3T3-L1 Adipocytes

(2009) J. Davis et al.   HORMONE AND METABOLIC RESEARCH

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids

(2009) Joo Y Lee et al.   NUTRITION REVIEWS

Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability

(2008) Takuya Suzuki et al.   BRITISH JOURNAL OF NUTRITION

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Human colonic microbiota associated with diet, obesity and weight loss

(2008) S H Duncan et al.   INTERNATIONAL JOURNAL OF OBESITY

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH

Metabolically healthy but obese individuals

(2008) Antony D Karelis   LANCET

Barrier-protective function of intestinal epithelial Toll-like receptor 2

(2008) E Cario   Mucosal Immunology

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark