Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro

(2018) Anindita Sarkar et al.   Cell Stem Cell

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

Epigenetics and cerebral organoids: promising directions in autism spectrum disorders

(2018) Sheena Louise Forsberg et al.   Translational Psychiatry

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

(2017) N Gunhanlar et al.   MOLECULAR PSYCHIATRY

Pluripotent stem cells in neuropsychiatric disorders

(2017) M A Soliman et al.   MOLECULAR PSYCHIATRY

Three-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds

(2017) Albin Jakobsson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Generation of pure GABAergic neurons by transcription factor programming

(2017) Nan Yang et al.   NATURE METHODS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

A multielectrode array microchannel platform reveals both transient and slow changes in axonal conduction velocity

(2017) Rouhollah Habibey et al.   Scientific Reports

Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders

(2017) Jackie J. Liu et al.   Molecular Brain

Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1

(2017) E. K. Stachowiak et al.   Translational Psychiatry

Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels

(2017) Arseniy Gladkov et al.   Scientific Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling psychiatric disorders with patient-derived iPSCs

(2016) Zhexing Wen et al.   CURRENT OPINION IN NEUROBIOLOGY

Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks

(2016) Renaud Renault et al.   LAB ON A CHIP

A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)

(2016) Kevin Alessandri et al.   LAB ON A CHIP

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Back to basics: luring industry back into neuroscience

(2016) Steven E Hyman   NATURE NEUROSCIENCE

In Vitro Reconstruction of Neuronal Networks Derived from Human iPS Cells Using Microfabricated Devices

(2016) Yuzo Takayama et al.   PLoS One

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

(2016) Xin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

(2016) Xiaobei Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

(2016) Zhen-Ning Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

(2016) F. Yi et al.   SCIENCE

Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders

(2016) David M. Panchision   STEM CELLS

Functional imaging of neuron–astrocyte interactions in a compartmentalized microfluidic device

(2016) Yandong Gao et al.   Microsystems & Nanoengineering

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele

(2016) Eileen N. Oni et al.   Scientific Reports

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

(2016) Nienke R. Wevers et al.   Scientific Reports

Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation

(2015) Li-Shiun Chen et al.   DRUG AND ALCOHOL DEPENDENCE

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

Two decades of new drug development for central nervous system disorders

(2015) Aaron S. Kesselheim et al.   NATURE REVIEWS DRUG DISCOVERY

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans

(2015) Kevin P Jensen et al.   NEUROPSYCHOPHARMACOLOGY

Barbed channels enhance unidirectional connectivity between neuronal networks cultured on multi electrode arrays

(2015) Joost le Feber et al.   Frontiers in Neuroscience

Combining Microfluidics, Optogenetics and Calcium Imaging to Study Neuronal Communication In Vitro

(2015) Renaud Renault et al.   PLoS One

How Far Can Mice Carry Autism Research?

(2014) Steven E. Hyman   CELL

A microfluidic based in vitro model of synaptic competition

(2014) Ainsley Coquinco et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Large-scale genomics unveils the genetic architecture of psychiatric disorders

(2014) Jacob Gratten et al.   NATURE NEUROSCIENCE

Improving and Accelerating Drug Development for Nervous System Disorders

(2014) Diana E. Pankevich et al.   NEURON

Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice

(2013) Yo SHINODA et al.   EXPERIMENTAL ANIMALS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

An organotypic uniaxial strain model using microfluidics

(2012) Jean-Pierre Dollé et al.   LAB ON A CHIP

Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations

(2012) N Farra et al.   MOLECULAR PSYCHIATRY

Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors

(2012) Anne Tammimäki et al.   NEUROPHARMACOLOGY

Modeling psychiatric disorders through reprogramming

(2011) K. J. Brennand et al.   Disease Models & Mechanisms

Valve-based microfluidic compression platform: single axon injury and regrowth

(2011) Suneil Hosmane et al.   LAB ON A CHIP

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

(2011) M. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic tools for analyzing the neural circuits of behavior

(2011) Jacob G. Bernstein et al.   TRENDS IN COGNITIVE SCIENCES

Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection

(2010) Amy N. Hellman et al.   LAB ON A CHIP

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Optogenetics: controlling cell function with light

(2010) Erika Pastrana   NATURE METHODS

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration

(2009) In Hong Yang et al.   EXPERIMENTAL NEUROLOGY

Microfluidics and multielectrode array-compatible organotypic slice culture method

(2008) Yevgeny Berdichevsky et al.   JOURNAL OF NEUROSCIENCE METHODS