Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders
Authors
Keywords
-
Journal
STEM CELLS
Volume 34, Issue 3, Pages 523-536
Publisher
Wiley
Online
2016-02-04
DOI
10.1002/stem.2295
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Bipolar disorder
- (2016) Iria Grande et al. LANCET
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies
- (2015) Michael W. Nestor et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients
- (2015) Aaron Topol et al. BIOLOGICAL PSYCHIATRY
- FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
- (2015) Jessica Mariani et al. CELL
- rsPSCs: A new type of pluripotent stem cells
- (2015) Uri Weissbein et al. CELL RESEARCH
- Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
- (2015) Lorenz Studer et al. Cell Stem Cell
- A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry
- (2015) Eli R. Zunder et al. Cell Stem Cell
- Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1
- (2015) ChangHui Pak et al. Cell Stem Cell
- Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules
- (2015) Wenxiang Hu et al. Cell Stem Cell
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial
- (2015) John McNeish et al. Cell Stem Cell
- Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
- (2015) R. Gao et al. CURRENT MOLECULAR MEDICINE
- Autism and the synapse
- (2015) Darius Ebrahimi-Fakhari et al. CURRENT OPINION IN NEUROLOGY
- In vitro myelin formation using embryonic stem cells
- (2015) B. E. Kerman et al. DEVELOPMENT
- Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells
- (2015) J. A. Tyson et al. DEVELOPMENT
- How to make a midbrain dopaminergic neuron
- (2015) E. Arenas et al. DEVELOPMENT
- Genetics and genomics of autism spectrum disorder: embracing complexity
- (2015) Silvia De Rubeis et al. HUMAN MOLECULAR GENETICS
- Cellular models to study bipolar disorder: A systematic review
- (2015) Biju Viswanath et al. JOURNAL OF AFFECTIVE DISORDERS
- Human-derived neural progenitors functionally replace astrocytes in adult mice
- (2015) Hong Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons
- (2015) J. S. Toma et al. JOURNAL OF NEUROSCIENCE
- hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells
- (2015) Brooke A. DeRosa et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Altered neuronal network and rescue in a human MECP2 duplication model
- (2015) S Nageshappa et al. MOLECULAR PSYCHIATRY
- Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking
- (2015) S Chanda et al. MOLECULAR PSYCHIATRY
- Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder
- (2015) S Bavamian et al. MOLECULAR PSYCHIATRY
- Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities
- (2015) J M Madison et al. MOLECULAR PSYCHIATRY
- Direct conversion of human fibroblasts to induced serotonergic neurons
- (2015) Z Xu et al. MOLECULAR PSYCHIATRY
- Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
- (2015) Fadi J. Najm et al. NATURE
- Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
- (2015) Jerome Mertens et al. NATURE
- Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model
- (2015) Julius A Steinbeck et al. NATURE BIOTECHNOLOGY
- Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
- (2015) Daniel Paull et al. NATURE METHODS
- Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
- (2015) Anca M Paşca et al. NATURE METHODS
- The PsychENCODE project
- (2015) Schahram Akbarian et al. NATURE NEUROSCIENCE
- High-throughput functional genomics using CRISPR–Cas9
- (2015) Ophir Shalem et al. NATURE REVIEWS GENETICS
- MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells
- (2015) Ugljesa Djuric et al. NEUROBIOLOGY OF DISEASE
- Cell-Based Screening: Extracting Meaning from Complex Data
- (2015) Steven Finkbeiner et al. NEURON
- Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
- (2015) Sacha B. Nelson et al. NEURON
- Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
- (2015) Cedric Bardy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A survey of human brain transcriptome diversity at the single cell level
- (2015) Spyros Darmanis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
- (2015) Michael P. Schwartz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes
- (2015) M. Demestre et al. Stem Cell Research
- Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells
- (2015) Katrina L. Adams et al. Nature Communications
- Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing
- (2015) Jubao Duan Neuroscience Bulletin
- Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate
- (2015) Priya Srikanth et al. Cell Reports
- Advances in Reprogramming to Pluripotency
- (2015) Suad Alateeq et al. Current Stem Cell Research & Therapy
- High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells
- (2015) Daman Kumari et al. Stem Cells Translational Medicine
- Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells
- (2015) Tomer Halevy et al. Stem Cell Reports
- MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del
- (2015) Dejian Zhao et al. PLoS One
- Applications for single cell trajectory analysis in inner ear development and regeneration
- (2014) Robert Durruthy-Durruthy et al. CELL AND TISSUE RESEARCH
- Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity
- (2014) Ki-Jun Yoon et al. Cell Stem Cell
- hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice
- (2014) Miles Cunningham et al. Cell Stem Cell
- Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
- (2014) Evangelos Kiskinis et al. Cell Stem Cell
- The developmental transcriptome of the human brain
- (2014) Andrew T.N. Tebbenkamp et al. CURRENT OPINION IN NEUROLOGY
- Induced neuronal reprogramming
- (2014) Cheen Euong Ang et al. JOURNAL OF COMPARATIVE NEUROLOGY
- A Competitive Advantage by Neonatally Engrafted Human Glial Progenitors Yields Mice Whose Brains Are Chimeric for Human Glia
- (2014) M. S. Windrem et al. JOURNAL OF NEUROSCIENCE
- Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons
- (2014) T Yoshimizu et al. MOLECULAR PSYCHIATRY
- Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
- (2014) K Griesi-Oliveira et al. MOLECULAR PSYCHIATRY
- Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
- (2014) K Brennand et al. MOLECULAR PSYCHIATRY
- Rapid neurogenesis through transcriptional activation in human stem cells
- (2014) V. Busskamp et al. Molecular Systems Biology
- Transcriptional landscape of the prenatal human brain
- (2014) Jeremy A. Miller et al. NATURE
- Synaptic dysregulation in a human iPS cell model of mental disorders
- (2014) Zhexing Wen et al. NATURE
- The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
- (2014) Cole Trapnell et al. NATURE BIOTECHNOLOGY
- Molecular and functional definition of the developing human striatum
- (2014) Marco Onorati et al. NATURE NEUROSCIENCE
- Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
- (2014) Xinmei Wen et al. NEURON
- A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
- (2014) Jason L. Stein et al. NEURON
- Temporal Specification and Bilaterality of Human Neocortical Topographic Gene Expression
- (2014) Mihovil Pletikos et al. NEURON
- Improving and Accelerating Drug Development for Nervous System Disorders
- (2014) Diana E. Pankevich et al. NEURON
- Transcription factor induction of human oligodendrocyte progenitor fate and differentiation
- (2014) J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome
- (2014) Jorge Castro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interneurons from Embryonic Development to Cell-Based Therapy
- (2014) D. G. Southwell et al. SCIENCE
- Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation
- (2014) Tae-Gon Kim et al. STEM CELLS
- iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth
- (2014) Matthew E. Doers et al. STEM CELLS AND DEVELOPMENT
- Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD
- (2014) Dae-Sung Kim et al. Frontiers in Cellular Neuroscience
- A Role for Noncoding Variation in Schizophrenia
- (2014) Panos Roussos et al. Cell Reports
- Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
- (2014) Brian J. Wainger et al. Cell Reports
- Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
- (2014) Yuan Tian et al. Genome Medicine
- Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients
- (2014) H M Chen et al. Translational Psychiatry
- Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation
- (2014) Celine E.F. de Esch et al. Stem Cell Reports
- Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons
- (2014) Vivian Hook et al. Stem Cell Reports
- Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
- (2014) Diana Xuan Yu et al. Stem Cell Reports
- International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper
- (2014) Filipa A.C. Soares et al. Stem Cell Reports
- Compartmental Genomics in Living Cells Revealed by Single-Cell Nanobiopsy
- (2013) Paolo Actis et al. ACS Nano
- Toward the future of psychiatric diagnosis: the seven pillars of RDoC
- (2013) Bruce N Cuthbert et al. BMC Medicine
- New Balance in Pluripotency: Reprogramming with Lineage Specifiers
- (2013) Uri Ben-David et al. CELL
- Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
- (2013) Justine D. Miller et al. Cell Stem Cell
- Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination
- (2013) Su Wang et al. Cell Stem Cell
- Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons
- (2013) Yun Li et al. Cell Stem Cell
- Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice
- (2013) Xiaoning Han et al. Cell Stem Cell
- Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
- (2013) Asif M. Maroof et al. Cell Stem Cell
- Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development
- (2013) Cory R. Nicholas et al. Cell Stem Cell
- Clinical pharmacology in neuroscience drug discovery: quo vadis?
- (2013) David G. Trist et al. CURRENT OPINION IN PHARMACOLOGY
- Altered neural connectivity in excitatory and inhibitory cortical circuits in autism
- (2013) Basilis Zikopoulos et al. Frontiers in Human Neuroscience
- Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells
- (2013) M. W. Amoroso et al. JOURNAL OF NEUROSCIENCE
- The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells
- (2013) Jeannine Gerhardt et al. MOLECULAR CELL
- Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients
- (2013) O Robicsek et al. MOLECULAR PSYCHIATRY
- Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
- (2013) D M Ruderfer et al. MOLECULAR PSYCHIATRY
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons
- (2013) Jocelyn F Krey et al. NATURE NEUROSCIENCE
- Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
- (2013) Yan Liu et al. Nature Protocols
- Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo
- (2013) Ira Espuny-Camacho et al. NEURON
- Revitalizing Psychiatric Therapeutics
- (2013) Steven E Hyman NEUROPSYCHOPHARMACOLOGY
- Use of “MGE Enhancers” for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons
- (2013) Ying-Jiun J. Chen et al. PLoS One
- Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex
- (2013) T. Kadoshima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells
- (2013) Xin Tang et al. Stem Cell Research
- Production and organization of neocortical interneurons
- (2013) Khadeejah T. Sultan et al. Frontiers in Cellular Neuroscience
- Widespread sex differences in gene expression and splicing in the adult human brain
- (2013) Daniah Trabzuni et al. Nature Communications
- The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline
- (2013) Margaret L Sutherland et al. Stem Cell Research & Therapy
- Brain Hyperconnectivity in Children with Autism and its Links to Social Deficits
- (2013) Kaustubh Supekar et al. Cell Reports
- Meeting Report: Using Stem Cells for Biological and Therapeutics Discovery in Mental Illness, April 2012
- (2013) David M. Panchision Stem Cells Translational Medicine
- Concise Review: The Involvement ofSOX2in Direct Reprogramming of Induced Neural Stem/Precursor Cells
- (2013) Christof Maucksch et al. Stem Cells Translational Medicine
- Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
- (2013) Ozlem Bozdagi et al. Molecular Autism
- Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening
- (2013) C Boissart et al. Translational Psychiatry
- Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons
- (2012) A. D. Carri et al. DEVELOPMENT
- A call for transparent reporting to optimize the predictive value of preclinical research
- (2012) Story C. Landis et al. NATURE
- Small molecules enable highly efficient neuronal conversion of human fibroblasts
- (2012) Julia Ladewig et al. NATURE METHODS
- Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
- (2012) Yichen Shi et al. NATURE NEUROSCIENCE
- Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
- (2012) Yichen Shi et al. Nature Protocols
- Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
- (2012) B. Bilican et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modeling human cortical development in vitro using induced pluripotent stem cells
- (2012) J. Mariani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
- (2012) N. Egawa et al. Science Translational Medicine
- Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives
- (2012) Ori Bar-Nur et al. Journal of Molecular Cell Biology
- Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
- (2011) Aaron Y.L. Cheung et al. HUMAN MOLECULAR GENETICS
- Spatio-temporal transcriptome of the human brain
- (2011) Hyo Jung Kang et al. NATURE
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
- (2011) Sergiu P Paşca et al. NATURE MEDICINE
- A System for Performing High Throughput Assays of Synaptic Function
- (2011) Chris M. Hempel et al. PLoS One
- Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome
- (2011) Steven D. Sheridan et al. PLoS One
- Developmental and Functional Nature of Human iPSC Derived Motoneurons
- (2011) Marianne Stockmann et al. Stem Cell Reviews and Reports
- Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
- (2010) Michael M. Halassa et al. Annual Review of Physiology
- A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
- (2010) Maria C.N. Marchetto et al. CELL
- Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
- (2010) Achia Urbach et al. Cell Stem Cell
- Animal models of neuropsychiatric disorders
- (2010) Eric J Nestler et al. NATURE NEUROSCIENCE
- Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
- (2009) Daniela Tropea et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals
- (2008) Mototsugu Eiraku et al. Cell Stem Cell
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now