Article
Environmental Sciences
Layra G. Cintron-Rivera, Nicole Burns, Ratna Patel, Jessica S. Plavicki
Summary: Human exposure to environmental pollutants can negatively impact embryonic development and health outcomes. This study utilized zebrafish as a model to explore the cellular and transcriptional targets of TCDD-induced craniofacial malformations. The findings reveal a reduction in jaw and pharyngeal chondrocytes, decreased collagen deposition, and impaired development of tissues derived from specific progenitor cells.
ENVIRONMENTAL POLLUTION
(2023)
Article
Nutrition & Dietetics
Wurood Hantoosh Neamah, Alex Rutkovsky, Osama Abdullah, Kiesha Wilson, Ryan Bloomquist, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study demonstrates that Resveratrol (RSV), an AhR antagonist, reduces the induction and function of murine myeloid-derived suppressor cells (MDSCs) induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). RSV reverses the effects of TCDD on macrophages and dendritic cells, as well as the upregulation of critical molecules involved in TCDD-mediated induction and immunosuppressive functions of MDSCs. RSV treatment decreases the energetic demands induced by TCDD. These findings suggest the potential use of RSV to attenuate the immunosuppressive properties of MDSCs.
Article
Environmental Sciences
Alexis Lopez, Kent Sorenson, Jeffrey Bamer, Randa Chichakli, Thomas Boivin, Daniel Moats
Summary: During the remediation of dioxin contamination at Danang airport, Incremental Sampling Methodology (ISM) was used to provide a more reliable estimate, better capturing distributional heterogeneity and reducing sampling variability compared to traditional methods.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Engineering, Environmental
Bao-Anh Thi Nguyen, Ju-Liang Hsieh, Shou-Chen Lo, Sui-Yuan Wang, Chun-Hsiung Hung, Eugene Huang, Shih-Hsun Hung, Wei-Chih Chin, Chieh-Chen Huang
Summary: In this study, the endophytic bacterium Burkholderia cenocapacia 869T2 was found to degrade the most toxic dioxin congener TCDD by nearly 95% after one-week of an aerobic incubation, with a potential general dioxin degradation pathway proposed. The investigation also revealed the crucial role of a catabolic gene, L-2-haloacid dehalogenase (2-HAD), in dioxin dehalogenation in aerobic conditions. Transcriptional analysis indicated high gene expressions of catabolic genes involved in dioxin metabolism in the presence of TCDD.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Rongrui Liu, Tim R. Zacharewski, Rory B. Conolly, Qiang Zhang
Summary: A human PBPK modeling framework for DLC mixtures was developed, which can flexibly simulate the exposure and internal burden of DLC mixtures. The results of simulations showed that tissue burdens of DLC mixtures were consistently lower than those of single exposure, except for the liver. The model also demonstrated marked differences in the contributions of individual congeners to blood or tissue toxic equivalency (TEQ) values compared to intake TEQ.
Article
Marine & Freshwater Biology
Layra G. Cintron-Rivera, Gabrielle Oulette, Aishwarya Prakki, Nicole M. Burns, Ratna Patel, Rachel Cyr, Jessica Plavicki
Summary: Dioxins are highly toxic and persistent environmental pollutants that have been shown to act as developmental teratogens. The most potent dioxin congener, TCDD, impairs nervous system, cardiac, and craniofacial development by activating the aryl hydrocarbon receptor (AHR). In zebrafish, TCDD exposure leads to craniofacial malformations through downregulation of sox9b, a member of the SoxE gene family. TCDD also affects the development of the zebrafish auditory system, specifically the otic vesicle, leading to structural deficits and altered collagen expression in the ears.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julio Bunay, Myriam Kossai, Christelle Damon-Soubeyrant, Angelique De Haze, Jean-Paul Saru, Amalia Trousson, Cyrille de Joussineau, Erwan Bouchareb, Ayhan Kocer, Marine Vialat, Sarah Dallel, Francoise Degoul, Frederic Bost, Stephan Clavel, Frederique Penault-Llorca, Marie-Pierre Valli, Laurent Guy, Jason Matthews, Yoan Renaud, Michael Ittmann, Jeffrey Jones, Laurent Morel, Jean-Marc Lobaccaro, Silvere Baron
Summary: Increasing evidence suggests a causal link between exposure to persistent organic pollutants (POPs) and increased incidence and aggressivity of various cancers. Dioxin and PCB-153, two widely found POPs, have been identified as significant sources of contamination. Experiments involving low doses of these POPs in ex vivo and in vivo models have shown that they increase growth and metastasis of prostate cancer cells. The up-regulation of Acetyl-CoA Acetyltransferase-1 (ACAT1) and ketone bodies pathway enzymes, identified as potential targets, has been confirmed in advanced prostate cancer. ACAT1 histoscore was also found to be significantly increased in patients exposed to the highly contaminated agent orange.
Article
Computer Science, Interdisciplinary Applications
Shun Yi, Jian Chen, Jia-jun Pan, Jue-hao Huang, Yue-feng Qiu
Summary: This study aims to investigate the influence of interlayer variability and spatial variabilities of intralayer soil parameters on the mechanical responses of a layered slope. An integrated random field is developed using FLAC program to characterize the uncertainty of intralayer and interlayer spatial variabilities. Monte-Carlo simulation is conducted to evaluate the influences of these variabilities on slope stability and risk. The results show that the failure mode of a two-layered slope changes significantly due to the stochastic layered boundary, and ignoring the uncertainty arising from layered boundary and transition zone may underestimate the probability and risk of slope failure. The proposed equations can be valuable for investigating the probability and risk associated with layered slopes.
COMPUTERS AND GEOTECHNICS
(2023)
Review
Biochemistry & Molecular Biology
Han-Bi Kim, Ji-Young Um, Bo-Young Chung, Jin-Cheol Kim, Seok-Young Kang, Chun-Wook Park, Hye-One Kim
Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.
Review
Biochemistry & Molecular Biology
Laura Gaspari, Francoise Paris, Nicolas Kalfa, Marie-Odile Soyer-Gobillard, Charles Sultan, Samir Hamamah
Summary: Previous studies indicate the potential for transgenerational inheritance of disease susceptibility due to endocrine disruptors. While there is substantial evidence on the multigenerational and transgenerational effects of TCDD, studies on its impact on human reproductive health are limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Toxicology
Andrey Korchevskiy
Summary: The paper explores the application of the benchmark dose method for carcinogen risk assessment in occupational health. By analyzing three case studies, it provides reasonable risk estimations based on dose-response data of different carcinogenic agents. The correlations between the proposed linear predictive models and observed data points were high, indicating the effectiveness of the method in approximating dose-response data on carcinogenic response.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Michelle E. Kossack, Katherine E. Manz, Nathan R. Martin, Kurt D. Pennell, Jessica Plavicki
Summary: Dioxin and dioxin-like compounds are environmental contaminants that induce toxicity by binding to the aryl hydrocarbon receptor (AHR). The zebrafish model has been used to study developmental toxicity caused by exposure to AHR ligands such as dioxin. In this study, targeted gas chromatography (GC) and non-targeted liquid chromatography (LC) were used to quantify TCDD uptake, model its elimination dynamics, and determine its impact on the zebrafish metabolome. The results showed that environmentally relevant body burdens of TCDD were produced in zebrafish through different waterborne exposures, and TCDD exposure affected metabolic pathways associated with AHR signaling and brain development.
Article
Pharmacology & Pharmacy
Maaike van Gerwen, Vikram Vasan, Eric Genden, Shira R. Saul
Summary: Thyroid cancer incidence has been steadily increasing since the 1970s, and exposure to environmental pollutants like TCDD and other dioxins may be a potential cause. This study reviewed available human studies on the association between TCDD exposure and thyroid cancer. Six studies were included, with results showing a non-significant increase in thyroid cancer risk from acute TCDD exposure in one case and a significant risk from Agent Orange exposure in two cases. One study evaluating TCDD exposure through herbicides found no association. More human studies are needed to further understand the potential link between TCDD exposure and thyroid cancer.
Article
Environmental Sciences
Malik Wajid Hussain Chan, Khwaja Ali Hasan, Danilo Balthazar-Silva, Zulfiqar Ali Mirani, Muhammad Asghar
Summary: The research assessed the levels of heavy metals in seawater and salt samples near Sandpit, Karachi, Pakistan, finding extremely high pollution index values and serious health hazards posed by heavy metals.
MARINE POLLUTION BULLETIN
(2021)
Article
Multidisciplinary Sciences
Ryuji Nagamine, Makoto Kawasaki, Kang-Il Kim, Akinori Sakai, Toru Suguro
Summary: The positional relationship between patellar and femoral articular surfaces can influence the patellar configuration, and the configuration may have a rhomboid transformation similar to the tibial condyle.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
A. L. Heffernan, T. K. Cunningham, D. S. Drage, L. L. Aylward, K. Thompson, S. Vijayasarathy, J. F. Mueller, S. L. Atkin, T. Sathyapalan
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2018)
Article
Medicine, Legal
Ted W. Simon
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Medicine, Legal
Sean M. Hays, Devika Poddalgoda, Kristin Macey, Lesa Aylward, Andy Nong
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Medicine, Legal
Lesa L. Aylward, Kim Irwin, Annie St-Amand, Andy Nong, Sean M. Hays
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Review
Toxicology
Shannon M. Bell, Xiaoqing Chang, John F. Wambaugh, David G. Allen, Mike Bartels, Kim L. R. Brouwer, Warren M. Casey, Neepa Choksi, Stephen S. Ferguson, Grazyna Fraczkiewicz, Annie M. Jarabek, Alice Ke, Annie Lumen, Scott G. Lynn, Alicia Paini, Paul S. Price, Caroline Ring, Ted W. Simon, Nisha S. Sipes, Catherine S. Sprankle, Judy Strickland, John Troutman, Barbara A. Wetmore, Nicole C. Kleinstreuer
TOXICOLOGY IN VITRO
(2018)
Article
Environmental Sciences
Leisa-Maree L. Toms, Andreas Sjodin, Peter Hobson, Fiona A. Harden, Lesa L. Aylward, Jochen F. Mueller
ENVIRONMENT INTERNATIONAL
(2018)
Article
Environmental Sciences
Peter Fantke, Lesa Aylward, Jane Bare, Weihsueh A. Chiu, Robin Dodson, Robert Dwyer, Alexi Ernstoff, Brett Howard, Matti Jantunen, Olivier Jolliet, Richard Judson, Nienke Kirchhubel, Dingsheng Li, Aubrey Miller, Greg Paoli, Paul Price, Lorenz Rhomberg, Beverly Shen, Hyeong-Moo Shin, Justin Teeguarden, Daniel Vallero, John Wambaugh, Barbara A. Wetmore, Rosemary Zaleski, Thomas E. McKone
ENVIRONMENTAL HEALTH PERSPECTIVES
(2018)
Article
Environmental Sciences
Lesa Aylward, Giulia Vilone, Christina Cowan-Ellsberry, Jon A. Arnot, John N. Westgate, Cian O'Mahony, Sean M. Hays
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
L. M. L. Toms, J. Braunig, S. Vijayasarathy, S. Phillips, P. Hobson, L. L. Aylward, M. D. Kirk, J. F. Mueller
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2019)
Article
Medicine, Legal
C. R. Kirman, T. W. Simon, S. M. Hays
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Environmental Sciences
Yan Li, Xianyu Wang, Leisa-Maree L. Toms, Chang He, Peter Hobson, Peter D. Sly, Lesa L. Aylward, Jochen F. Mueller
ENVIRONMENTAL RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Sarah Faure, Nolwenn Noisel, Kate Werry, Subramanian Karthikeyan, Lesa L. Aylward, Annie St-Amand
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2020)
Article
Environmental Sciences
Daniel S. Drage, Amy L. Heffernan, Thomas K. Cunningham, Lesa L. Aylward, Jochen F. Mueller, Thozhukat Sathyapalan, Stephen L. Atkin
ENVIRONMENTAL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Harshal Deshmukh, Lesa L. Aylward, Martin Rose, Alwyn Fernandes, Peter Sedman, Natalie J. Thatcher, Stephen L. Atkin, Thozhukat Sathyapalan
CLINICAL ENDOCRINOLOGY
(2020)
Article
Environmental Sciences
Marc-Andre Verner, Hassan Salame, Conrad Housand, Linda S. Birnbaum, Maryse F. Bouchard, Jonathan Chevrier, Lesa L. Aylward, Daniel Q. Naiman, Judy S. LaKind
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)