In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

(2013) Nisha S. Sipes et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells

(2013) Daniel M. Rotroff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of the Toxicity Forecasting Capability of EPA's ToxCast Phase I Data: Can ToxCast In Vitro Assays Predict Carcinogenicity?

(2013) ROMUALDO BENIGNI   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

(2013) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

A Computational Model Predicting Disruption of Blood Vessel Development

(2013) Nicole Kleinstreuer et al.   PLoS Computational Biology

Disruption of embryonic vascular development in predictive toxicology

(2012) Thomas B. Knudsen et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

(2012) Richard S. Judson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos

(2012) John Cowden et al.   REPRODUCTIVE TOXICOLOGY

Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program

(2012) Matthew T. Martin et al.   Systems Biology in Reproductive Medicine

In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

(2012) Nicole C. Kleinstreuer et al.   TOXICOLOGICAL SCIENCES

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

(2011) Matthew T Martin et al.   BIOLOGY OF REPRODUCTION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

(2011) Ruili Huang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

(2011) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

(2011) Imran Shah et al.   PLoS One

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

(2011) Kelly J. Chandler et al.   PLoS One

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

(2011) S. Padilla et al.   REPRODUCTIVE TOXICOLOGY

The exposure data landscape for manufactured chemicals

(2011) Peter P. Egeghy et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Virtual Tissues in Toxicology

(2010) Imran Shah et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

Simulating Microdosimetry in a Virtual Hepatic Lobule

(2010) John Wambaugh et al.   PLoS Computational Biology

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

(2009) Andrew W. Knight et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB

(2009) Thomas B. Knudsen et al.   REPRODUCTIVE TOXICOLOGY

Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database

(2009) Matthew T. Martin et al.   TOXICOLOGICAL SCIENCES

A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model

(2008) Richard Judson et al.   BMC BIOINFORMATICS

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

The Toxicity Data Landscape for Environmental Chemicals

(2008) Richard Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

(2008) Matthew T. Martin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

ACToR — Aggregated Computational Toxicology Resource

(2008) Richard Judson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY