Article
Nutrition & Dietetics
Laura Keaver, Christine Houlihan, Niamh O'Callaghan, Amy E. LaVertu, Xinge Ding, Fang Fang Zhang
Summary: This study aimed to document European guidelines for healthcare professionals regarding the nutritional management of cancer survivors, assess their quality, and summarize the nutrition recommendations. Five guidelines met the inclusion criteria, with ESPEN guidelines found to have the highest methodological quality. However, the guidelines lacked detailed nutrition information for cancer survivors and their healthcare team, as well as practical strategies for implementing recommendations. There is a need for specific nutrition guidelines for cancer survivors in Europe.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, Legal
C. R. Kirman, P. J. Boogaard, J. S. Bus, V. L. Dellarco, L. R. DePass, B. R. Stern, S. M. Hays
Summary: An international panel of experts assessed the cancer weight of evidence (WOE) for three lower acrylates and concluded that they are not likely to be carcinogenic to humans. The panel also determined the mechanism of action for point of contact tumors observed in rodent cancer bioassays. Additionally, they emphasized the importance of relying on non-cancer endpoints for human health risk assessment.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xiaomeng Li, Mengmei Ni, Zhirui Yang, Xuxi Chen, Lishi Zhang, Jinyao Chen
Summary: This study investigates the potential modes of action of BPA in reproductive/developmental toxicity, neurological toxicity, and proliferative effects on the mammary gland and the prostate using bioinformatics analysis and the QWOE approach. Common target genes and pathways involved in BPA-induced action are identified, with two potential estrogen receptor-related modes of action proposed. Further research is needed to improve the risk assessment of BPA.
ENVIRONMENTAL POLLUTION
(2021)
Article
Genetics & Heredity
Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu, Qing Wang
Summary: The study utilized bioinformatics analysis to establish the mechanistic mode of action (MOA) of Cd-induced renal tubular dysfunction based on perturbed toxicity pathways during Cd-induced nephrotoxicity. The overall MOA of Cd-induced renal tubular dysfunction showed a moderate confidence level, with evidence gaps that need to be filled by rational experimental designs.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Irene Julca, Daniela Mutwil-Anderwald, Vaishnervi Manoj, Zahra Khan, Soak Kuan Lai, Lay. K. K. Yang, Ing. T. T. Beh, Jerzy Dziekan, Yoon. P. P. Lim, Shen. K. K. Lim, Yee. W. W. Low, Yuen. I. I. Lam, Seth Tjia, Yuguang Mu, Qiao. W. W. Tan, Przemyslaw Nuc, Le. M. M. Choo, Gillian Khew, Loo Shining, Antony Kam, James. P. P. Tam, Zbynek Bozdech, Maximilian Schmidt, Bjoern Usadel, Yoganathan Kanagasundaram, Saleh Alseekh, Alisdair Fernie, Hoi. Y. Y. Li, Marek Mutwil
Summary: This study reveals the biosynthetic pathway of active metabolites in the Oldenlandia group and the mode of action of ursolic acid in cancer cells, providing valuable resources for further characterization of active metabolite biosynthesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Review
Medicine, General & Internal
Arri Coomarasamy, Rima K. Dhillon-Smith, Argyro Papadopoulou, Maya Al-Memar, Jane Brewin, Vikki M. Abrahams, Abha Maheshwari, Ole B. Christiansen, Mary D. Stephenson, Mariette Goddijn, Olufemi T. Oladapo, Chandrika N. Wijeyaratne, Debra Bick, Hassan Shehata, Rachel Small, Phillip R. Bennett, Lesley Regan, Raj Rai, Tom Bourne, Rajinder Kaur, Oonagh Pickering, Jan J. Brosens, Adam J. Devall, Ioannis D. Gallos, Siobhan Quenby
Summary: Women who have experienced recurrent miscarriages often have uncertainties about the causes, risks, necessary investigations, and treatments. This paper suggests individualized care and a minimum set of investigations and treatments for couples with a history of recurrent miscarriage, while emphasizing screening and care for mental health issues and future obstetric risks. Health care services may consider a graded care model to provide appropriate care for these couples.
Article
Toxicology
A. Kende, F. Lai, P. P. Lim, L. Swindale, A. Hofstra, F. Zhang, E. McInnes, R. Currie, D. Cowie
Summary: In long-term rodent studies, the administration of Cyclobutrifluram showed a slight increase in hepatocellular carcinomas in male CD-1 mice. This increase was within the historical control range and appeared to be dose responsive. In vitro studies confirmed Cyclobutrifluram's ability to activate mouse constitutive androstane receptor (CAR) mediated gene transcription. A 28-day dietary toxicity study in male CD-1 mice was conducted to assess the CAR activation mode of action hypothesis of Cyclobutrifluram.
TOXICOLOGY LETTERS
(2023)
Article
Agriculture, Multidisciplinary
Zhengjun Liu, Qing X. Li, Baoan Song
Summary: This article reviews the pesticidal activities and modes of action of frequently studied monoterpenes based on publications and patents found in SciFinder Scholar. The information and perspectives presented are intended to be useful for the development of monoterpenes as biopesticides and monoterpenoid pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Oncology
Jann Arends, Maurizio Muscaritoli, Stefan Anker, Riccardo Audisio, Rocco Barazzoni, Snezana Bosnjak, Paolo Bossi, Jacqueline Bowman, Stefan Gijssels, Zeljko Krznaric, Florian Strasser, Matti Aapro
Summary: Cachexia, a life-threatening condition in cancer patients, poses challenges in clinical management due to the lack of routine malnutrition screening and integration of nutrition care into oncology practice. In June 2020, a multidisciplinary task force was convened to address the barriers hindering timely recognition of cancer cachexia and provide practical recommendations for improved care. This position paper summarizes key points and highlights available resources to support the integration of structured nutrition care pathways.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Clinical Neurology
Manoj K. Doss, Maxwell B. Madden, Andrew Gaddis, Mary Beth Nebel, Roland R. Griffiths, Brian N. Mathur, Frederick S. Barrett
Summary: Classic psychedelic drugs have potential in treating psychiatric disorders, and the involvement of the serotonin 2A receptor and the cerebral cortex is crucial in their action. Different models, including the CSTC model, REBUS model, and CCC model, have been proposed to explain the impact of 5-HT2A activation on neural systems during psychedelic drug effects.
Article
Multidisciplinary Sciences
A. Sylvia S. Schleker, Marc Rist, Christiane Matera, Arunas Damijonaitis, Ursel Collienne, Koichi Matsuoka, Samer S. Habash, Katja Twelker, Oliver Gutbrod, Corinna Saalwaechter, Maren Windau, Svend Matthiesen, Tatyana Stefanovska, Melanie Scharwey, Michael T. Marx, Sven Geibel, Florian M. W. Grundler
Summary: Fluopyram is a highly effective and selective inhibitor of succinate dehydrogenase in plant-parasitic nematodes. It impairs ATP generation, causing paralysis in nematodes. Fluopyram shows different efficacy against different PPN species, possibly due to amino acid differences in the SDHC gene.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Tao Hong, Tao Ying, Qing Huang, Sachith E. Dissanayake, Yiming Qiu, Mark M. Turnbull, Andrey A. Podlesnyak, Yan Wu, Huibo Cao, Yaohua Liu, Izuru Umehara, Jun Gouchi, Yoshiya Uwatoko, Masaaki Matsuda, David A. Tennant, Gia-Wei Chern, Kai P. Schmidt, Stefan Wessel
Summary: In this study, a class of quantum phase transitions that do not fit into the traditional Landau paradigm is discovered by investigating the magnetic structure and spin dynamics of a spin-1/2 ladder compound under hydrostatic pressure. The breakdown of the Neel-ordered phase and the existence of an exotic quantum-disordered phase beyond the critical pressure are revealed, suggesting that this transition may fall outside the traditional Landau paradigm.
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Multidisciplinary
Yue Zhang, Jing Li, Xiaoyu Liu, Wei Gao, Shuoshuo Song, Yaping Rong, Linyu Tan, Tatiana V. Glukhareva, Vasiliy A. Bakulev, Zhijin Fan
Summary: Lead discovery and molecular target identification are crucial for the development of novel pesticides. This study utilized a scaffold-hopping strategy to design and synthesize 24 new ferimzone derivatives. In vitro and in vivo bioassays demonstrated that certain derivatives exhibited similar or improved potency against various fungal pathogens compared to ferimzone. Additionally, density functional theory calculations provided insight into the structure-energy relationship. These findings contribute to the understanding of the mode of action of ferimzone and suggest potential candidates for further development as pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Monika Staniszewska, Lukasz Kuryk, Aleksander Gryciuk, Joanna Kawalec, Marta Rogalska, Joanna Baran, Anna Kowalkowska
Summary: This study aimed to characterize the action mode of N-phenacyldibromobenzimidazoles against C. albicans and C. neoformans. The results showed that compound 5h exhibited excellent antifungal activity against both C. albicans and C. neoformans, exerting fungicidal effects and inhibiting virulence factors in Candida-dependent manner.
Article
Biochemical Research Methods
Rens Janssens, Xian Zhang, Audrey Kauffmann, Antoine de Weck, Eric Y. Durand
Summary: A novel unsupervised deep learning algorithm was introduced in this study to cluster cellular images with similar Mode-of-Action (MOA) using only pixel intensity values, achieving competitive results in correctly classifying MOA with 97.09% accuracy on the labeled subset of the BBBC021 dataset. The method does not require the extraction of cell candidates, can be trained on unannotated datasets, and has the potential to discover novel MOAs and annotate unlabeled compounds.