Oncostatin M and its role in fibrosis

Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis

(2018) Giuseppina Stifano et al.   Arthritis & Rheumatology

Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice

(2017) Michitaka Matsuda et al.   HEPATOLOGY

The IL-31/IL-31 receptor axis: general features and role in tumor microenvironment

(2017) Elisa Ferretti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer

(2017) Jacob M. Smigiel et al.   MOLECULAR CANCER RESEARCH

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling

(2017) D J Junk et al.   ONCOGENE

Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum

(2017) Marta Cossu et al.   Arthritis & Rheumatology

Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

(2017) Ehab A. Ayaub et al.   Scientific Reports

Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway

(2016) Xiaotian Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

OP0048 IL-31 Is An Inflammatory Pro-Fibrotic Factor Elevated in A Subset of Scleroderma Patients with Severe Pruritus

(2016) N. Arumalla et al.   ANNALS OF THE RHEUMATIC DISEASES

Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial–mesenchymal transition and poor overall survival

(2016) Justyna A Kucia-Tran et al.   BRITISH JOURNAL OF CANCER

Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation

(2016) Mathilde Pohin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oncostatin M-Preconditioned Mesenchymal Stem Cells Alleviate Bleomycin-Induced Pulmonary Fibrosis Through Paracrine Effects of the Hepatocyte Growth Factor

(2016) Ying-Wei Lan et al.   Stem Cells Translational Medicine

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function

(2016) Brijendra Singh et al.   PLoS One

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

(2016) Peter J. Wermuth et al.   PLoS One

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Oncostatin M regulates osteogenic differentiation of murine adipose-derived mesenchymal progenitor cells through a PKCdelta-dependent mechanism

(2015) David C. Smyth et al.   CELL AND TISSUE RESEARCH

Oncostatin M binds to extracellular matrix in a bioactive conformation: Implications for inflammation and metastasis

(2015) Randall E. Ryan et al.   CYTOKINE

Systems biology of IL-6, IL-12 family cytokines

(2015) Anna Dittrich et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

(2015) Heike M. Hermanns   CYTOKINE & GROWTH FACTOR REVIEWS

Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3

(2015) X. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus–Related Liver Cirrhosis

(2015) Desong Ming et al.   VIRAL IMMUNOLOGY

Endothelial dysfunction in systemic sclerosis

(2014) Nezam Altorok et al.   CURRENT OPINION IN RHEUMATOLOGY

Microvascular Endothelial Cells Poised to Take Center Stage in Experimental Renal Fibrosis

(2014) I. Daehn et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oncostatin M overexpression induces matrix deposition, STAT3 activation and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice

(2014) Steven Wong et al.   LABORATORY INVESTIGATION

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia

(2013) G. Hoermann et al.   ALLERGY

Endothelial Cells Recruit Macrophages and Contribute to a Fibrotic Milieu in Bleomycin Lung Injury

(2013) Heather G. Leach et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oncostatin M Modulates Fibroblast Function via Signal Transducers and Activators of Transcription Proteins–3

(2013) Kumi Yoneda Nagahama et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure

(2013) Jochen Pöling et al.   BASIC RESEARCH IN CARDIOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials

(2013) Ernest H Choy et al.   ARTHRITIS RESEARCH & THERAPY

Oncostatin M inhibits TGF-β1-induced CTGF expression via STAT3 in human proximal tubular cells

(2012) Rita Sarközi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases

(2012) Toshio Tanaka et al.   International Journal of Biological Sciences

Increased KGF Expression Promotes Fibroblast Activation in a Double Paracrine Manner Resulting in Cutaneous Fibrosis

(2012) Johanna Canady et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Interleukin-6: from an inflammatory marker to a target for inflammatory diseases

(2012) Mercedes Rincon   TRENDS IN IMMUNOLOGY

Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis

(2012) Lukasz Stawski et al.   ARTHRITIS RESEARCH & THERAPY

Potential of Oncostatin M to accelerate diabetic wound healing

(2012) Soo Hye Shin et al.   International Wound Journal

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ

(2010) Svitlana Demyanets et al.   BASIC RESEARCH IN CARDIOLOGY

Serum human cartilage glycoprotein-39 in patients with systemic sclerosis: relationship to skin and articular manifestation

(2010) Dominika Wcislo-Dziadecka et al.   CLINICAL RHEUMATOLOGY

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis

(2010) Maria Trojanowska   Nature Reviews Rheumatology

Structures and biological functions of IL-31 and IL-31 receptors

(2008) Qing Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Human mast cells release oncostatin M on contact with activated T cells: Possible biologic relevance

(2007) Pazit Salamon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY