Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins

ACE2 and AT4R are present in diseased human blood vessels

(2015) A Zulli et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium

(2013) Michelle M. Monasky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1and B2receptors through a STAT6-dependent mechanism

(2013) PPC Souza et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual kinin B1 and B2 receptor activation provides enhanced blood–brain barrier permeability and anticancer drug delivery into brain tumors

(2013) Jérôme Côté et al.   CANCER BIOLOGY & THERAPY

Role of angiotensin AT2receptors in natriuresis: Intrarenal mechanisms and therapeutic potential

(2013) Robert M Carey et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Bradykinin B2 Receptor in the Adrenal Medulla of Male Rats and Mice: Glucocorticoid-Dependent Increase With Immobilization Stress

(2013) Regina Nostramo et al.   ENDOCRINOLOGY

Immunohistochemical detection of angiotensin II receptors in mouse cerebellum and adrenal gland using “in vivo cryotechnique”

(2013) Zheng Huang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus

(2013) Marilia G.A.G. Pereira et al.   HYPERTENSION

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

(2013) Virna Cortez-Retamozo et al.   IMMUNITY

The Arrestin-selective Angiotensin AT1Receptor Agonist [Sar1,Ile4,Ile8]-AngII Negatively Regulates Bradykinin B2Receptor Signaling via AT1-B2Receptor Heterodimers

(2013) Parker C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

(2013) Katherine J. Elliott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lack of kinin B1 receptor potentiates leptin action in the liver

(2013) Raphael Gomes Fonseca et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Bradykinin-Induced Chemotaxis of Human Gliomas Requires the Activation of KCa3.1 and ClC-3

(2013) V. A. Cuddapah et al.   JOURNAL OF NEUROSCIENCE

Stimulation of ANP by angiotensin-(1-9) via the angiotensin type 2 receptor

(2013) Seung Ah. Cha et al.   LIFE SCIENCES

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Activation of the Kinin B1 Receptor Attenuates Melanoma Tumor Growth and Metastasis

(2013) Patricia Dillenburg-Pilla et al.   PLoS One

Beneficial Effects of the Activation of the Angiotensin-(1–7) Mas Receptor in a Murine Model of Adriamycin-Induced Nephropathy

(2013) Kátia Daniela Silveira et al.   PLoS One

Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer

(2013) Marie-Odile Guimond et al.   PROSTATE

GPCR biased ligands as novel heart failure therapeutics

(2013) Jonathan D. Violin et al.   TRENDS IN CARDIOVASCULAR MEDICINE

β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury

(2012) Ki-Seok Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Brain kinin B1 receptor contributes to the onset of stereotypic nocifensive behavior in rat

(2012) H. De Brito Gariepy et al.   BEHAVIOURAL BRAIN RESEARCH

Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation

(2012) F. Langhauser et al.   BLOOD

Effects of kinin B1and B2receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats

(2012) Stefânia Forner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunohistochemical localization of the angiotensin-(1–7) receptor Mas in the murine forebrain

(2012) M. Freund et al.   CELL AND TISSUE RESEARCH

Functionally Selective AT1Receptor Activation Reduces Ischemia Reperfusion Injury

(2012) Anders Hostrup et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors

(2012) Xianming Zhang et al.   CELLULAR SIGNALLING

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

(2012) Guido Boerrigter et al.   Circulation-Heart Failure

Angiotensin Receptor Blockers and Tumorigenesis: Something To Be (or Not To Be) Concerned About?

(2012) Vadim Tchaikovski et al.   CURRENT HYPERTENSION REPORTS

Which, if any, antihypertensive agents cause cancer?

(2012) Amita Singh et al.   CURRENT OPINION IN CARDIOLOGY

Angiotensin Receptor Blockade Increases Pancreatic Insulin Secretion and Decreases Glucose Intolerance during Glucose Supplementation in a Model of Metabolic Syndrome

(2012) Ruben Rodriguez et al.   ENDOCRINOLOGY

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

Expression Patterns of Kinin-Dependent Genes in Endometrial Cancer

(2012) Joanna Orchel et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Kinin-B2 Receptor Activity Determines the Differentiation Fate of Neural Stem Cells

(2012) Cleber A. Trujillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Tissue specific localization of angiotensin-(1–7) and its receptor Mas in the uterus of ovariectomized rats

(2012) João Vaz-Silva et al.   JOURNAL OF MOLECULAR HISTOLOGY

Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat

(2012) Sébastien Talbot et al.   Journal of Neuroinflammation

Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia

(2012) Sébastien Talbot et al.   Journal of Neuroinflammation

A comparison of the effects of Angiotensin IV on androgen-dependent and androgen-independent prostate cancer cell lines

(2012) Kamila Domińska et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy

(2012) Zhen Liu et al.   LABORATORY INVESTIGATION

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

(2012) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF DISEASE

The kallikrein–kinin-system in head and neck squamous cell carcinoma (HNSCC) and its role in tumour survival, invasion, migration and response to radiotherapy

(2012) Carolin Beck et al.   ORAL ONCOLOGY

Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation

(2012) Kamila Domińska et al.   PEPTIDES

Blockade of early and late retinal biochemical alterations associated with diabetes development by the selective bradykinin B1 receptor antagonist R-954

(2012) Orlando Catanzaro et al.   PEPTIDES

Ocular Application of the Kinin B1 Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

(2012) Mylène Pouliot et al.   PLoS One

Adenoviral Delivery of Angiotensin-(1-7) or Angiotensin-(1-9) Inhibits Cardiomyocyte Hypertrophy via the Mas or Angiotensin Type 2 Receptor

(2012) Monica Flores-Muñoz et al.   PLoS One

Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis

(2012) Bhavani Krishnan et al.   PROSTATE

Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1

(2012) Bhavani Krishnan et al.   PROSTATE

Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway

(2012) Hsin-Shan Yu et al.   PROSTATE

The Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas receptor axis: A potential target for treating thrombotic diseases

(2012) Rodrigo Fraga-Silva et al.   THROMBOSIS AND HAEMOSTASIS

Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease

(2012) Ming-Sheng Zhou et al.   VASCULAR MEDICINE

Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension

(2012) John W. Wright et al.   International Journal of Hypertension

Des-aspartate-angiotensin-I and angiotensin IV improve glucose tolerance and insulin signalling in diet-induced hyperglycaemic mice

(2011) Yong-Chiat Wong et al.   BIOCHEMICAL PHARMACOLOGY

Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway

(2011) Saghir Akhtar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines

(2011) Guido Boerrigter et al.   Circulation-Heart Failure

The influence of body mass index and renin–angiotensin–aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men

(2011) Anand Vaidya et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Physiological function of the angiotensin AT1a receptor in bone remodeling

(2011) Keiko Kaneko et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bradykinin-mediated cell proliferation depends on transactivation of EGF receptor in corneal fibroblasts

(2011) Ching-Yi Cheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors

(2011) V. Montana et al.   JOURNAL OF NEUROSCIENCE

The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes

(2011) Anand Vaidya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor

(2011) Hui Yang et al.   PEPTIDES

Enalaprilat-Mediated Activation of Kinin B1 Receptors and Vasodilation in the Rat Isolated Perfused Kidney

(2011) Rocio Bautista-Pérez et al.   PHARMACOLOGY

Brain renin-angiotensin—A new look at an old system

(2011) John W. Wright et al.   PROGRESS IN NEUROBIOLOGY

Making It Short and Sweet

(2011) E. M. Adler   Science Signaling

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

(2011) Maria Fernanda Graciano et al.   Islets

Interaction between Adiponectin and Aldosterone

(2011) Colleen Flynn et al.   CardioRenal Medicine

PKA-mediated effect of MAS receptor in counteracting angiotensin II-stimulated renal Na+-ATPase

(2010) Lucienne S. Lara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells

(2010) Pamela Ehrenfeld et al.   CANCER LETTERS

GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats

(2010) Prabhakara Reddy Nagareddy et al.   CARDIOVASCULAR RESEARCH

Inhibition of the renin–angiotensin system prevents seizures in a rat model of epilepsy

(2010) Marilia G.A.G. Pereira et al.   CLINICAL SCIENCE

Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary

(2010) Fernando M. Reis et al.   FERTILITY AND STERILITY

Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry

(2010) Irene van den Broek et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Angiotensin (1–7) and its receptor Mas are expressed in the human testis: implications for male infertility

(2010) Augusto B. Reis et al.   JOURNAL OF MOLECULAR HISTOLOGY

Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent

(2010) Ting Du et al.   JOURNAL OF NEUROCHEMISTRY

The Angiotensin IV Analog Nle-Tyr-Leu- -(CH2-NH2)3-4-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor

(2010) B. J. Yamamoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Bradykinin Decreases Podocyte Permeability through ADAM17-Dependent Epidermal Growth Factor Receptor Activation and Zonula Occludens-1 Rearrangement

(2010) M. Dey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blockade of the Kinin B1 Receptor Ameloriates Glomerulonephritis

(2010) J. Klein et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fyn is involved in angiotensin II type 2 receptor-induced neurite outgrowth, but not in p42/p44mapk in NG108-15 cells

(2010) M.-O. Guimond et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

(2010) Regina A Oyesanya et al.   Molecular Cancer

Bradykinin B2 Receptor Interacts with Integrin  5 1 to Transactivate Epidermal Growth Factor Receptor in Kidney Cells

(2010) I. I. Kramarenko et al.   MOLECULAR PHARMACOLOGY

Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors

(2010) F. Kuhr et al.   NEUROPEPTIDES

Attenuation of Persistent Experimental Pancreatitis Pain by a Bradykinin B2 Receptor Antagonist

(2010) Qingmin Chen et al.   PANCREAS

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice

(2010) M. Kakoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8

(2009) C. Methner et al.   Acta Physiologica

Stimulation of the bradykinin B1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway

(2009) Luis Molina et al.   BREAST CANCER RESEARCH AND TREATMENT

Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy

(2009) D. Westermann et al.   DIABETES

The brain RAS and Alzheimer's disease

(2009) John W. Wright et al.   EXPERIMENTAL NEUROLOGY

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

(2009) Jihee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

(2009) Belen Joglar et al.   JOURNAL OF NEUROCHEMISTRY

Intramuscular renin–angiotensin system is activated in human muscular dystrophy

(2009) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The role of the central renin-angiotensin system in Parkinson’s disease

(2009) Birgit Mertens et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The kallikrein–kinin system in health and in diseases of the kidney

(2009) Masao Kakoki et al.   KIDNEY INTERNATIONAL

Receptor Type Protein Tyrosine Phosphatase-Kappa Mediates Cross-Talk between Transforming Growth Factor-Beta and Epidermal Growth Factor Receptor Signaling Pathways in Human Keratinocytes

(2009) Yiru Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: Effects on hippocampal glucose levels and blood flow

(2009) Dimitri De Bundel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Kinins in cardiac inflammation and regeneration: Insights from ischemic and diabetic cardiomyopathy

(2009) Konstantinos Savvatis et al.   NEUROPEPTIDES

Expression of tissue and plasma kallikreins and kinin B1 and B2 receptors in lung cancer

(2008) Jessica Chee et al.   BIOLOGICAL CHEMISTRY

Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-α. Effects dependent on activation of NF-κB and MAP kinases

(2008) Anna Bernhold Brechter et al.   BONE

Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis

(2008) O Arrieta et al.   BRITISH JOURNAL OF CANCER

Activation of kinin B1receptor triggers differentiation of cultured human keratinocytes

(2008) C.E. Matus et al.   BRITISH JOURNAL OF DERMATOLOGY

The renin-angiotensin system and malignancy

(2008) E. I. Ager et al.   CARCINOGENESIS

ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes

(2008) C. Tikellis et al.   DIABETES

Angiotensin II accelerates osteoporosis by activating osteoclasts

(2008) Hideo Shimizu et al.   FASEB JOURNAL

Angiotensin II Type 2 Receptor Blockade Increases Bone Mass

(2008) Yayoi Izu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Does Arrestin Assemble MAPKs into a Signaling Complex?

(2008) Xiufeng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Renin–Angiotensin System Induces Osteoporosis Independently of Hypertension

(2008) Yutaro Asaba et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Brain renin angiotensin in disease

(2008) M. Ian Phillips et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Characterization of a Local Renin-Angiotensin System in Rat Gingival Tissue

(2008) C.F. Santos et al.   JOURNAL OF PERIODONTOLOGY

The sweeter side of ACE2: Physiological evidence for a role in diabetes

(2008) Sharell M. Bindom et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Kinin B2 Receptor Mediates Induction of Cyclooxygenase-2 and Is Overexpressed in Head and Neck Squamous Cell Carcinomas

(2008) W. Zhang et al.   MOLECULAR CANCER RESEARCH

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells

(2008) Jun-ichi Teranishi et al.   PROSTATE

Modulation of B1 and B2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy

(2007) Marilia G.A.G. Pereira et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Participation of kallikrein–kinin system in different pathologies

(2007) Claudio M. Costa-Neto et al.   INTERNATIONAL IMMUNOPHARMACOLOGY