Article
Urology & Nephrology
Benedikt Marahrens, Arndt Schulze, Jan Wysocki, Meei-Hua Lin, Minghao Ye, Yashpal S. Kanwar, Michael Bader, Juan Carlos Q. Velez, Jeffrey H. Miner, Daniel Batlle
Summary: The study found that aminopeptidase A deficiency results in increased blood pressure and altered glomerular structure in mice, but without significant proteinuria. Additionally, the activity, protein, and mRNA levels of certain enzymes in the renin-angiotensin system in the kidney may be regulated compensatory in knockout mice.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Giovanna Castoldi, Raffaella Carletti, Silvia Ippolito, Isabella Villa, Biagio Palmisano, Simona Bolamperti, Alessandro Rubinacci, Gianpaolo Zerbini, Michela Meani, Giovanni Zatti, Cira R. T. di Gioia
Summary: The study found that angiotensin II-dependent hypertension led to increased urinary excretion of calcium and phosphate, without significantly affecting bone density.
Review
Peripheral Vascular Disease
Shawna D. Nesbitt
Summary: firibastat is a novel antihypertension medication with a unique mechanism targeting the brain renin angiotensin system. Recent clinical trials have shown its effectiveness and safety in treating mild and resistant hypertension, with significant reduction in blood pressure and minimal side effects particularly in difficult-to-treat patients. This new therapeutic class offers new pathways to consider and enhances the current regimens available for hypertension treatment.
CURRENT HYPERTENSION REPORTS
(2021)
Article
Medicine, Research & Experimental
Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes
Summary: The study found that the tritherapy of firibastat, enalapril, and HCTZ significantly improved the blood pressure control and arginine-vasopressin release in deoxycorticosterone acetate-salt rats, compared to bitherapy with enalapril and HCTZ.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ann Tenneil O'Connor, Dhanush Haspula, Ahmed Z. Alanazi, Michelle A. Clark
Summary: This review examines the molecular and biological actions of angiotensin III (Ang III) and provides insight into its potential role in metabolic diseases.
Review
Pharmacology & Pharmacy
Shogo Shimizu
Summary: Overactive bladder is a condition that affects both men and women, and current treatments have limitations. This review highlights the potential of targeting the brain AT1 receptor for the treatment of overactive bladder, as Ang II and the AT1 receptor play important roles in the micturition reflex. The study explores the effects of central Ang II administration and the inhibition of the AT1 receptor on the micturition reflex, suggesting a potential therapeutic approach.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: This article reviews the role of the renin-angiotensin system in stroke neuroprotection. The effects of the renin-angiotensin system on receptors were observed, and the neuroprotective properties seem to be independent of the blood pressure reduction mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
Summary: Studies suggest that blood-brain barrier crossing renin-angiotensin drugs may be linked to less memory decline, while nonpenetrant medications may help improve attention.
Article
Medicine, Research & Experimental
Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie -Isabel Aguilar, Chengxue Helena Qin, Chrishan S. Samuel, Tracey A. Gaspari, Robert E. Widdop
Summary: This study aimed to investigate the effects of angiotensin II type 2 receptor (AT2R) stimulation in a model of hypertension with type 1 diabetes mellitus (T1DM). The results showed that the AT2R agonist attenuated cardiac fibrosis, inflammatory markers, and superoxide levels in diabetic spontaneously hypertensive rats (SHRs). However, the AT1R blocker did not show the same protective effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Tomas Jasenovec, Dominika Radosinska, Marta Kollarova, Peter Balis, Stefan Zorad, Norbert Vrbjar, Iveta Bernatova, Sona Cacanyiova, Lubomira Tothova, Jana Radosinska
Summary: The study found that ACE2 inhibition had negative effects on erythrocytes in SHRs, while taxifolin treatment showed potential in lowering blood pressure and reducing obesity. Additionally, taxifolin exhibited erythroprotective effects.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Review
Medicine, General & Internal
Adrian Martyniak, Przemyslaw J. Tomasik
Summary: Cardiovascular disease is the leading cause of death worldwide and hypertension is a serious medical issue in both adults and children. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in regulating blood pressure and electrolyte balance. Recent studies reveal that the RAAS system acts not only through endocrine pathways but also through paracrine, autocrine, and intracrine pathways. The alternative pathways of RAAS, which include components like Ang 1-7 and Mas receptors, have been found to have antihypertensive and cardioprotective effects. Proteolytic enzymes such as angiotensin convertase enzyme type 1 and 2 are also important in the functioning of the RAAS system and serve as therapeutic targets for hypertension. Furthermore, tissue-specific enzymes contribute to the local renin-angiotensin system. The ACE2/ang 1-7/MasR axis shows promising potential for new treatments in hypertension.
Article
Pharmacology & Pharmacy
Gabriela Maria Lucera, Jose Vanderlei Menani, Eduardo Colombari, Debora Simoes Almeida Colombari
Summary: This study investigated the involvement of angiotensin II and aldosterone in regulating sodium intake in renovascular hypertension rats, as well as the effects of central AT1 and mineralocorticoid receptor antagonists on blood pressure levels. The results suggest that ANG II and aldosterone act centrally to increase sodium intake, while AT1 and mineralocorticoid receptor antagonists have an impact on hypertension levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Hironori Nakagami, Tetsuya Ishihama, Yuichi Daikyoji, Chieka Sasakura, Ei Yamada, Ryuichi Morishita
Summary: The study on an angiotensin II vaccine for hypertension, AGMG0201, showed good safety and tolerability in patients with mild to moderate hypertension, with the ability to induce anti-angiotensin II antibodies.
HYPERTENSION RESEARCH
(2022)