Article
Biochemistry & Molecular Biology
Rosemary Wangensteen, Manuel Gomez-Guzman, Inmaculada Banegas, Isabel Rodriguez-Gomez, Rosario Jimenez, Juan Duarte, Joaquin Garcia-Estan, Felix Vargas
Summary: This study investigated the vasoactive effects of DAA-I in rats and found that it increased blood pressure and caused vasoconstriction. These effects were mediated by the activation of AT1 receptors. These findings have potential implications for the treatment of cardiovascular diseases.
Article
Immunology
Manuela Bratti, Shamila Vibhushan, Cyril Longe, Despoina Koumantou, Gael Menasche, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Summary: The study found that IRAP-positive endosomal compartments play a significant role in promoting inhibition of SHP-1 and controlling the extent of phosphorylation events at the plasma membrane, thus impacting the severity of immune-complex triggered inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
M. J. Ramirez-Exposito, M. P. Carrera-Gonzalez, J. M. Martinez-Martos
Summary: The study showed that the renin angiotensin system plays a role in tumor growth in the rat model of glioma, with increased levels of aspartyl aminopeptidase and aminopeptidase B activities, as well as decreased levels of aminopeptidase N, aminopeptidase A, and insulin-regulated aminopeptidase activities. These findings suggest the predominant actions of angiotensin III against a decreased action of angiotensin II and IV in tumor growth.
BRAIN RESEARCH BULLETIN
(2021)
Article
Physiology
Yvonne Zuchowski, Joshua Carty, Andrew S. Terker, Fabian Bock, Jonathan B. Trapani, Gautam Bhave, Jason A. Watts, Susanna Keller, Mingzhi Zhang, Roy Zent, Raymond C. Harris, Juan Pablo Arroyo
Summary: This study aims to understand the response of mice lacking IRAP to an acute water load. The results showed that IRAP-deficient mice have a high urinary osmolality at baseline and are unable to excrete free water in response to water loading. These findings reveal a novel regulatory role for IRAP in urine concentration and dilution.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Frida Stam, Sara Floren Lind, Anja Schroff, Sofia Zelleroth, Erik Nylander, Johan Gising, Alfhild Gronbladh, Mats Larhed, Mathias Hallberg
Summary: Angiotensin IV is a bioactive peptide that inhibits insulin-regulated aminopeptidase. HA08, a potent IRAP inhibitor, can restore cell viability in cells damaged by hydrogen peroxide.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Neurosciences
Maria Jesus Ramirez-Exposito, Jose Manuel Martinez-Martos, Vanesa Canton-Habas, Maria Del Pilar Carrera-Gonzalez
Summary: There is a connection between type II diabetes and Alzheimer's disease, both related to estradiol exposure and affecting glucose homeostasis. Environmental contaminants such as BPA could impact beta-pancreatic cell function similar to estradiol, potentially influencing the development of Alzheimer's disease. The pathway involving IRAP/GLUT4 is emerging as a target for pharmacological intervention against AD.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Nathalie Rohmann, Liasita Munthe, Kristina Schlicht, Corinna Geisler, Tobias J. Demetrowitsch, Corinna Bang, Julia Jensen-Kroll, Kathrin Tuerk, Petra Bacher, Andre Franke, Karin Schwarz, Dominik M. Schulte, Matthias Laudes
Summary: This study found that obesity and metabolic abnormalities are more common in individuals with allergies, especially contact allergies. Contact allergies were strongly associated with hyperlipidemia and dietary intake of polyunsaturated fatty acids, while hay fever was linked to low physical activity, shorter sleep duration, and changes in gut microbiota composition. Genetic predisposition to hyperlipidemia was found to be associated with both contact allergies and hay fever.
Article
Nutrition & Dietetics
German Dominguez-Vias, Ana Belen Segarra, Manuel Ramirez-Sanchez, Isabel Prieto
Summary: This study found that prolonged feeding with a high-fat diet affects the function of the HPA axis by influencing the renin-angiotensin-aldosterone system, and different types of fat have different effects on the aminopeptidase activity in the HPA axis.
Article
Agriculture, Multidisciplinary
Md Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan
Summary: Ginsenoside derivatives exhibit significant inhibitory effects on ACE, with protopanaxatriol, protopanaxadiol, and ginsenoside Rh2 showing the most potent inhibition. Molecular docking studies confirmed that ginsenosides inhibit ACE through hydrogen bonds and hydrophobic interactions. Additionally, ginsenosides also stimulate glucose uptake in insulin-resistant cells and have antioxidant properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sudarsana Reddy Vanga, Johan Aqvist, Anders Hallberg, Hugo Gutierrez-de-Teran
Summary: Inhibition of insulin-regulated aminopeptidase can enhance memory and cognition in animal models. A new binding model was proposed and validated through computational simulations, providing valuable insights for further optimization of novel IRAP inhibitors.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Nutrition & Dietetics
Meng-Jie Tsai, Chung-Hao Li, Hung-Tsung Wu, Hsin-Yu Kuo, Chung-Teng Wang, Hsiu-Ling Pai, Chih-Jen Chang, Horng-Yih Ou
Summary: Although sugar substitutes are recommended for weight and glycemic control, studies show that artificial sweeteners have adverse effects on glycemic homeostasis. This study found that sucralose administration increased insulin secretion and decreased plasma glucose levels in mice. However, long-term sucralose consumption augmented high-fat diet-induced insulin resistance and glucose intolerance, and this effect was mediated through the T1R3-ERK1/2 signaling pathway.
Article
Biochemistry & Molecular Biology
Xiaojie Cheng, Jiali Jiang, Chunjun Li, Changhu Xue, Biao Kong, Yaoguang Chang, Qingjuan Tang
Summary: This study assessed the hypoglycemic effect of compound enzymatic hydrolysate (CEH) of Neoporphyra haitanensis. The results showed that CEH reduced blood glucose level, alleviated insulin resistance, and regulated the gut microbiome. Additionally, CEH affected pathways related to glycometabolism.
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Peripheral Vascular Disease
Ying Lin, Ya-qi Li, Hui Wang, Hao-jie Wu, Bao-ling Bai, Li-juan Ma, Ji-zhen Zou, Qin Zhang, Lin Shi
Summary: This study identified H3K27ac as an important histone acetylation site that activates ACE1 in the kidneys of high-fat diet-induced hypertensive rats.
JOURNAL OF HYPERTENSION
(2022)
Article
Obstetrics & Gynecology
Filiz Yarsilikal Guleroglu, Aliye Balkan Ozmen, Isil Turan Bakirci, Sevilay Yavuz Dogu, Ibrahim Yilmaz, Ali Cetin
Summary: The study aimed to determine the predictive values of fetal pancreas size and maternal serum biomarkers GA and IRAP for gestational diabetes mellitus (GDM). The results showed that these parameters have no potential for early prediction of GDM at the 20-22 weeks of gestation, and further studies are needed to clarify their role in the antenatal care of women with GDM.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Pharmacology & Pharmacy
Kok-Onn Lee, Edmund Feng Tian, Martin Hui Cai, Hong Wang, Yiong-Huak Chan, Meng-Kwoon Sim
Article
Endocrinology & Metabolism
H. Q. Li, C. F. Lu, J. Wang, G. P. Yin, R. Sun, X. H. Xu, B. L. Liu, F. F. Li, T. Jing, K. O. Lee, L. Ye, J. H. Ma, X. F. Su
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Article
Biochemistry & Molecular Biology
Asha Recino, Shu Uin Gan, Kian Chuan Sia, Yvonne Sawyer, Jenny Trendell, Richard Kay, Fiona M. Gribble, Frank Reimann, Rob Foale, Maria Notaridou, Nick Holmes, Andrew Lever, Kok Onn Lee, Amit Nathwani, Anne Cooke, Roy Calne, Maja Wallberg
Article
Biotechnology & Applied Microbiology
Shu Uin Gan, Zhenying Fu, Kian Chuan Sia, Oi Lian Kon, Roy Calne, Kok Onn Lee
JOURNAL OF GENE MEDICINE
(2019)
Review
Cell Biology
Nur Shabrina Amirruddin, Blaise Su Jun Low, Kok Onn Lee, E. Shyong Tai, Adrian Kee Keong Teo
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Rengna Yan, Yun Hu, Fengfei Li, Lanlan Jiang, Xiaohua Xu, Jie Wang, Ying Zhang, Lei Ye, Kok Onn Lee, Xiaofei Su, Jianhua Ma
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Maoyuan Chen, Huiqin Li, Yun Shen, Bingli Liu, Renna Yan, Xiaojuan Sun, Lei Ye, Kok-Onn Lee, Jianhua Ma, Xiaofei Su
Summary: Using Flash Glucose Monitoring (FGM) to monitor glucose levels can help people with Type 2 Diabetes Mellitus (T2DM) achieve better glucose control through adjustments in daily diet and exercise without changing medication.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Endocrinology & Metabolism
Yun Hu, Bo Ding, Yun Shen, Reng-Na Yan, Feng-Fei Li, Rui Sun, Ting Jing, Kok-Onn Lee, Jian-Hua Ma
Summary: The study found that in men with type 2 diabetes mellitus, oral metformin for one month can lower serum testosterone levels. Compared with the control group, the metformin group showed a significant decrease in testosterone levels. Further research is needed to investigate the long-term effects of metformin on testosterone in men.
Article
Medicine, Research & Experimental
Xiaomei Liu, Xianghong Xu, Cunnan Mao, Peng Zhang, Qing Zhang, Lanlan Jiang, Yuyin Yang, Jianhua Ma, Lei Ye, Kok-Onn Lee, Jindan Wu, Zhijian Yao
Summary: The present study explored changes in thalamo-cortical functional connectivity (FC) of patients with painful diabetic neuropathy (PDN) using resting-state functional MRI, finding increased FC in the left thalamus, right angular gyrus, and occipital gyrus among PDN patients compared to those without pain. This increased connectivity may be a central pathophysiological mechanism for PDN.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Nur Shabrina Amirruddin, Wei Xuan Tan, Yaw Sing Tan, Daphne Su-Lyn Gardner, Yong Mong Bee, Chandra Shekhar Verma, Shawn Hoon, Kok Onn Lee, Adrian Kee Keong Teo
Summary: This study examined the effects of heterozygous human INS gene mutations on insulin secretion and ER stress, revealing that mutant INS induces ER stress and defects in insulin processing, leading to decreased insulin secretion. Overexpression of mutant INS resulted in dominant-negative effects on insulin secretory capacity of beta cells after 9 weeks, with compensatory upregulation of genes involved in insulin secretion observed in patient-derived beta-like cells.
Article
Biochemistry & Molecular Biology
Kian Chuan Sia, Shu Uin Gan, Siti Humairah Mohd Rodhi, Zhen Ying Fu, John J. Kopchick, Michael J. Waters, Kok Onn Lee
Summary: This study is the first to use gene therapy to treat GH-receptor deficiency. By injecting AAV-GHR, the serum GH levels decrease and the levels of GH-responsive IGF1, IGFBP3, and ALS increase in mice. It also causes a limited increase in body weight and length, similar to the response to rhIGF1 treatment in LS patients. This study is of great importance for the development of gene therapy for human LS treatment.
Review
Medicine, Research & Experimental
Hwee Hui Lau, Shu Uin Gan, Heiko Lickert, Andrew Mark James Shapiro, Kok Onn Lee, Adrian Kee Keong Teo
Summary: The discovery of insulin a century ago revolutionized the lives of individuals with diabetes, but there is still significant room for improvement towards a cure. By summarizing key milestones and recent technological advances in recombinant insulin, the future of insulin replacement therapies holds promise for effectively treating diabetes in the next century.
Article
Endocrinology & Metabolism
Li Fu, Kevin C. J. Yuen, Aye Nyein Tint, Andrew R. Hoffman, Ariff T. Bongso, Kok Onn Lee
Summary: The study found that decreased sperm motility in infertile men with asthenozoospermia is associated with increased levels of IGF-I, IGF-II, IGFBP-2, and PSA in seminal plasma. Changes in seminal plasma IGFs and their interactions with IGFBPs and IGF receptors, as well as PSA levels, suggest a role of these seminal plasma peptides in modulating sperm motility and possibly in the development of prostate disease in aging men.
Article
Cell Biology
Kian Chuan Sia, Zhen Ying Fu, Roy Y. Calne, Amit C. Nathwani, Kok Onn Lee, Shu Uin Gan
Article
Endocrinology & Metabolism
Jie Wang, Bing-Li Liu, Zheng Li, Hui-Qin Li, Rui Sun, Yun Hu, Kok-Onn Lee, Lei Ye, Xiao-Fei Su, Jian-Hua Ma
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)