NADPH oxidases as therapeutic targets in ischemic stroke

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox5 Forms a Functional Oligomer Mediated by Self-Association of Its Dehydrogenase Domain

(2011) Tsukasa Kawahara et al.   BIOCHEMISTRY

Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury

(2011) Jia Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial

(2011) Else Charlotte Sandset et al.   LANCET

NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion

(2011) Kazutoshi Murotomi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Celastrol: A New Therapeutic Potential of Traditional Chinese Medicine

(2010) T. Morita   AMERICAN JOURNAL OF HYPERTENSION

PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

(2010) Xianghuai Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

Inhibition of gp91phox contributes towards normobaric hyperoxia afforded neuroprotection in focal cerebral ischemia

(2010) Xiangqi Tang et al.   BRAIN RESEARCH

Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats

(2010) Tiziana Genovese et al.   BRAIN RESEARCH

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Does oxidative stress contribute to the pathology of Friedreich’s ataxia? A radical question

(2010) Jeffrey S. Armstrong et al.   FASEB JOURNAL

Oxidative stress and endothelial dysfunction in cerebrovascular disease

(2010) Sophocles Chrissobolis   Frontiers in Bioscience-Landmark

Nadph Oxidase Mediates Striatal Neuronal Injury after Transient Global Cerebral Ischemia

(2010) Hideyuki Yoshioka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms Contributing to Cerebral Infarct Size after Stroke: Gender, Reperfusion, T Lymphocytes, and Nox2-Derived Superoxide

(2010) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of peroxisome proliferator-activated receptor γ, and effects of its agonist, rosiglitazone, on transient cerebral ischemic damage

(2010) Choong Hyun Lee et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Targeting NADPH Oxidase and Phospholipases A2 in Alzheimer’s Disease

(2010) Agnes Simonyi et al.   MOLECULAR NEUROBIOLOGY

NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice

(2010) Timo Kahles et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway

(2010) H.-L. Zhang et al.   NEUROSCIENCE

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

(2010) Juan M. Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia

(2010) Alyson A. Miller et al.   STROKE

Reperfusion Therapies for Acute Ischemic Stroke: Current Pharmacological and Mechanical Approaches

(2010) C. A. Molina   STROKE

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

(2009) Thomas L. Leto et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke

(2009) Katherine A. Jackman et al.   BRAIN RESEARCH

NOX2 inhibition with apocynin worsens stroke outcome in aged rats

(2009) Kimberly A. Kelly et al.   BRAIN RESEARCH

Post-ischemic blood–brain barrier leakage in rats: One-week follow-up by MRI

(2009) Aysan Durukan et al.   BRAIN RESEARCH

The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial

(2009) Jesse Dawson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice

(2009) KA Jackman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondria, oxidative stress, and temporal lobe epilepsy

(2009) Simon Waldbaum et al.   EPILEPSY RESEARCH

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CK2 Is a Novel Negative Regulator of NADPH Oxidase and a Neuroprotectant in Mice after Cerebral Ischemia

(2009) G. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

(2009) Simon A. Woodcock et al.   MOLECULAR CELL

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Gender Influences Cerebral Vascular Responses to Angiotensin II Through Nox2-Derived Reactive Oxygen Species

(2009) T. Michael De Silva et al.   STROKE

Delayed Hypoxic Postconditioning Protects Against Cerebral Ischemia in the Mouse

(2009) Claire Leconte et al.   STROKE

NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2

(2008) Alyson A. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase as a therapeutic target in Alzheimer's disease

(2008) Michelle L Block   BMC NEUROSCIENCE

Brain endothelial cells and the glio-vascular complex

(2008) Hartwig Wolburg et al.   CELL AND TISSUE RESEARCH

Targeting cerebrovascular Rho-kinase in stroke

(2008) Hwa Kyoung Shin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Interference With PPARγ Signaling Causes Cerebral Vascular Dysfunction, Hypertrophy, and Remodeling

(2008) Andreas M. Beyer et al.   HYPERTENSION

Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome

(2008) Asokan Anbanandam et al.   JOURNAL OF MOLECULAR BIOLOGY

Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

The Akt signaling pathway contributes to postconditioning’s protection against stroke; the protection is associated with the MAPK and PKC pathways

(2008) Xuwen Gao et al.   JOURNAL OF NEUROCHEMISTRY

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice

(2008) Christina Doverhag et al.   NEUROBIOLOGY OF DISEASE

Apocynin improves outcome in experimental stroke with a narrow dose range

(2008) X.N. Tang et al.   NEUROSCIENCE

The blood–brain barrier is continuously open for several weeks following transient focal cerebral ischemia

(2008) D. Strbian et al.   NEUROSCIENCE

Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice

(2008) Yuko Nonaka et al.   NEUROSCIENCE LETTERS

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events

(2008) Salim Yusuf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

(2008) Stavros Selemidis et al.   PHARMACOLOGY & THERAPEUTICS

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allopurinol Use Yields Potentially Beneficial Effects on Inflammatory Indices in Those With Recent Ischemic Stroke

(2008) Scott W. Muir et al.   STROKE

Ischemic Postconditioning Inhibits Apoptosis After Focal Cerebral Ischemia/Reperfusion Injury in the Rat

(2008) Bianzhi Xing et al.   STROKE

Pericyte Signaling in the Neurovascular Unit

(2008) M. Fisher   STROKE

NXY-059 for the Treatment of Acute Stroke

(2008) Hans-Christoph Diener et al.   STROKE

Ischemic Postconditioning Protects Against Global Cerebral Ischemia/Reperfusion-Induced Injury in Rats

(2008) Jing-ye Wang et al.   STROKE

The role of oxidative stress and NADPH oxidase in cerebrovascular disease

(2008) Sophocles Chrissobolis et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondria in multiple sclerosis

(2007) Pedram Ghafourifar   Frontiers in Bioscience-Landmark

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION