The benzazole scaffold: a SWAT to combat Alzheimer's disease

Design, synthesis and structure–activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

(2013) Jinhe Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Developments in Direct CH Arylation of (Hetero)Arenes under Microwave Irradiation

(2013) Abhishek Sharma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles

(2013) Valentin N. Bochatay et al.   JOURNAL OF ORGANIC CHEMISTRY

Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease

(2013) Maria A. Telpoukhovskaia et al.   Molecular BioSystems

Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker

(2012) Nadav Amdursky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dye-Binding Assays for Evaluation of the Effects of Small Molecule Inhibitors on Amyloid (Aβ) Self-Assembly

(2012) Laramie P. Jameson et al.   ACS Chemical Neuroscience

Palladium-catalyzed direct arylation of benzoxazoles with unactivated simple arenes

(2012) Ge Wu et al.   CHEMICAL COMMUNICATIONS

Biomimetic Oxidative Coupling of Benzylamines and 2-Aminophenols: Synthesis of Benzoxazoles

(2012) Yoshinori Endo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

Diagnostic imaging of Alzheimer's disease with copper and technetium complexes

(2012) James L. Hickey et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Metal compounds as inhibitors of β-amyloid aggregation. Perspectives for an innovative metallotherapeutics on Alzheimer's disease

(2012) Daniela Valensin et al.   COORDINATION CHEMISTRY REVIEWS

Novel 18F-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral β-Amyloid Plaques in Alzheimer’s Disease

(2012) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

(2012) Jie Geng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemistry and Biological Activities of 1,3-Benzothiazoles

(2012) Victor Facchinetti et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

A New Trend in the Experimental Methodology for the Analysis of the Thioflavin T Binding to Amyloid Fibrils

(2012) Irina M. Kuznetsova et al.   MOLECULAR NEUROBIOLOGY

Benzazoles from Aliphatic Amines and o-Amino/Mercaptan/Hydroxyanilines: Elemental Sulfur as a Highly Efficient and Traceless Oxidizing Agent

(2012) Thanh Binh Nguyen et al.   ORGANIC LETTERS

Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18F]fluorobenzothiazoles as a potential positron emission tomography imaging probe for β-amyloid plaques

(2011) Byung Chul Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insight into Amyloid Structure Using Chemical Probes

(2011) Ashley A. Reinke et al.   Chemical Biology & Drug Design

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

(2011) Fumiya Mito et al.   CHEMICAL COMMUNICATIONS

Direct Arylation of Benzothiazoles and Benzoxazoles with Aryl Boronic Acids

(2011) Sadananda Ranjit et al.   CHEMISTRY-A EUROPEAN JOURNAL

The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

(2011) Yong Zhang et al.   DALTON TRANSACTIONS

Kumada Coupling of Aryl, Heteroaryl, and Vinyl Chlorides Catalyzed by Amido Pincer Nickel Complexes

(2011) Ning Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C–H Functionalization/C–N/C–O Bond Formation

(2011) Murali Mohan Guru et al.   JOURNAL OF ORGANIC CHEMISTRY

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Aerobic Visible-Light Photoredox Radical C–H Functionalization: Catalytic Synthesis of 2-Substituted Benzothiazoles

(2011) Yannan Cheng et al.   ORGANIC LETTERS

Highly practical boronic acid surrogates for the Suzuki–Miyaura cross-coupling

(2011) Hélène Bonin et al.   TETRAHEDRON LETTERS

Synthesis and evaluation of 18F-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease

(2010) B. Neumaier et al.   APPLIED RADIATION AND ISOTOPES

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

(2010) Maria Laura Bolognesi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pd-Catalyzed Decarboxylative Arylation of Thiazole, Benzoxazole, and Polyfluorobenzene with Substituted Benzoic Acids

(2010) Kai Xie et al.   ORGANIC LETTERS

Bienzymatic synthesis of benzothia/(oxa)zoles in aqueous medium

(2010) Atul Kumar et al.   TETRAHEDRON LETTERS

N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy

(2010) Lauren E. Scott et al.   Chemical Science

Electrochemical Oxidation of Benzothiazole Dyes for Monitoring Amyloid Formation Related to the Alzheimer’s Disease

(2009) Anthony Joseph Veloso et al.   ANALYTICAL CHEMISTRY

Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve

(2009) Olivier Querbes, Florent Aubry, Jérémie Pariente, Jean-Albert Lotterie, Jean-François Démonet, Véronique Duret, Michèle Puel, Isabelle Berry, Jean-Claude Fort et al.   BRAIN

2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery

(2009) A. Weekes et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and Evaluation of18F-Labeled 2-Phenylbenzothiazoles as Positron Emission Tomography Imaging Agents for Amyloid Plaques in Alzheimer’s Disease

(2009) Kim Serdons et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles

(2009) Prasenjit Saha et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CH Functionalization/CN Bond Formation: Copper-Catalyzed Synthesis of Benzimidazoles from Amidines

(2008) Gordon Brasche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease

(2008) K. Serdons et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed IntramolecularO-Arylation: Synthesis of 2-Aryl Benzoxazoles

(2008) Julien Bonnamour et al.   ORGANIC LETTERS

Iron(II) Bromide-Catalyzed Synthesis of Benzimidazoles from Aryl Azides

(2008) Meihua Shen et al.   ORGANIC LETTERS

Oxidative cyclization of thiophenolic and phenolic Schiff's bases promoted by PCC: a new oxidant for 2-substituted benzothiazoles and benzoxazoles

(2008) C. Praveen et al.   TETRAHEDRON

Thioflavin Derivatives as Markers for Amyloid-β Fibrils: Insights into Structural Features Important for High-Affinity Binding

(2007) Rodrigue Leuma Yona et al.   ChemMedChem