Article
Biochemistry & Molecular Biology
Ly Porosk, Heleri Heike Hark, Renata Naporano Bicev, Ilja Gaidutsik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva, Ulo Langel
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that causes dementia, and its pathophysiological dynamics are driven by genetics with high heterogeneity in biological alterations and causes. The disease is characterized by the progression of aggregated amyloid-beta (A beta) or Tau neurofibrillary tangles. Current treatments for AD are not efficient, but recent breakthroughs have led to the discovery of potential therapeutic targets such as reducing brain inflammation and limiting A beta aggregation. This study demonstrates the successful use of A beta interacting protein sequences, particularly derived from Transthyretin, to reduce or target amyloid aggregation, and also predicts anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Akshay Kapadia, Krishna K. Sharma, Indresh Kumar Maurya, Varinder Singh, Madhu Khullar, Rahul Jain
Summary: The synthesis of tetrapeptides based on the C-terminus fragment of A beta peptide showed promising protection against A beta aggregation-mediated neurotoxicity in PC-12 cells, with enhanced blood-brain barrier permeability and proteolytic stability. Structural insights and computational studies on ligand-A beta interactions offer new avenues for the advancement of peptide-derived therapeutics for AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jimin Kwak, Junhyeok Woo, Seongmin Park, Mi Hee Lim
Summary: This review highlights rational strategies for designing photo-activatable metal complexes as chemical sensors or modulators to probe and alter aggregation pathways of A-beta peptides, with examples.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Chemistry, Medicinal
Nibedita Ghosh, Lal Mohan Kundu
Summary: Alzheimer's disease is a progressive neurodegenerative disorder, with focus on anti-amyloid breaker peptides derived from the A beta sequence and non-A beta-based peptides. These breaker peptides include various modifications and are important for research and treatment of AD.
FUTURE MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Daniela Malafaia, Helio M. T. Albuquerque, Artur M. S. Silva
Summary: Alzheimer's disease is a common form of dementia in the elderly with no cure currently available. Multi-target compounds show promise in addressing various factors related to AD. Accumulation of Aβ plaques and NFTs are key features of AD, attracting significant research attention for early diagnosis and treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Bo Jiang, Angel A. Marti
Summary: Metal complexes in photoluminescence spectroscopy have been utilized for the detection of amyloid aggregates, exhibiting specific responses in the presence of these aggregates such as intensity changes, emission wavelength shifts, variations in lifetime, and anisotropy changes.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Salvatore Mamone, Stefan Gloeggler, Stefan Becker, Nasrollah Rezaei-Ghaleh
Summary: The amyloid cascade hypothesis suggests that Aβ aggregation is the initial trigger of Alzheimer's disease, with Aβ42 having higher aggregation propensity than Aβ40. The C-terminal region of Aβ, especially the G33-L34-M35 segment, plays a specific role in the early stages of Aβ aggregation, providing a target for the rational design of Aβ42 aggregation inhibitors.
Article
Chemistry, Multidisciplinary
Jiai Hua, Xueman Wei, Yujian Bian, Xiang Ma, Li Hao, Jierui Sun, Jingjing Fan, Yulan Niu, Yanqing Wang
Summary: A novel sandwich-type phosphomolybdate incorporating a novel hexagonal calcium phosphorus oxygen cluster was synthesized and shown to modulate the misfolding conformation of A beta in Alzheimer's disease and suppress the production of reactive oxygen species.
Article
Chemistry, Analytical
Yan Fang, Qi Wang, Chenlong Xiang, Guijin Liu, Junjian Li
Summary: Beta-amyloid is important in the pathology of Alzheimer's disease and its abnormal production and aggregation can be used for early diagnosis. A novel fluorescent probe, PTPA-QM, was designed and synthesized for detection of beta-amyloid in the brain. PTPA-QM has good selectivity and high fluorescence intensity in glycerol solution. It also has excellent membrane permeability and low toxicity.
Article
Chemistry, Analytical
Cen Ding, Changhong Li, Qing Meng, Chengyuan Qian, Changli Zhang, Liu Yang, Xiaohui Wang, Yanqing Wang
Summary: A label-free fluorescent probe (BTS) was reported for dynamic in situ visualization of A beta 40 aggregation. The probe binds to all forms of A beta 40 with high affinity and can monitor the entire A beta aggregation process with high selectivity and sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D. Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luis F. Ribeiro, Joris Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau
Summary: The study found that proteins enriched in homologous sequences to Aβ aggregation-prone regions are present in Aβ plaques from AD patients, suggesting heterotypic amyloid interactions may occur. These proteins can modify Aβ assembly kinetics, fibril morphology, and deposition pattern in vitro. Additionally, it was discovered that transient expression of three of these proteins in an Aβ reporter cell line promotes Aβ amyloid aggregation, indicating a potential role of heterotypic APR interactions in amyloid-deposition diseases.
Review
Biochemistry & Molecular Biology
Giuseppe Di Natale, Giuseppina Sabatino, Michele Francesco Maria Sciacca, Rita Tosto, Danilo Milardi, Giuseppe Pappalardo
Summary: In the last two decades, the amyloid hypothesis has been the mainstream concept in Alzheimer's Disease research. However, recent evidence suggests that tau accumulation is more closely related to cognitive decline and AD development. Failed clinical trials of amyloid-targeting drug candidates imply the need for significant amendments to the amyloid hypothesis. This article discusses the potential dangerous relationships between A beta oligomeric species and tau protein and explores the molecular determinants underlying their cross interactions.
Article
Chemistry, Medicinal
Misato Tajiri, Ryo Yamada, Mayumi Hotsumi, Koki Makabe, Hiroyuki Konno
Summary: This study describes the total synthesis of berberine and selected analogues, and evaluates their effectiveness as amyloid beta (Aβ) aggregation inhibitors. The key step in the synthesis is the assembly of the berberine framework using an intermolecular Heck reaction. Berberine analog 17, incorporating a tertiary amine moiety, demonstrated good anti-Aβ aggregation activity, water solubility, and minimal toxicity to nerve cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Neurosciences
Somayra S. A. Mamsa, Bruno P. Meloni
Summary: CARPs are effective therapeutic compounds for neurodegenerative diseases, reducing excitotoxic cell death and mitochondrial dysfunction through multimodal mechanisms. Arginine is known to prevent protein misfolding and aggregation, suggesting potential for CARPs to also prevent aggregation and cytotoxicity of amyloidogenic proteins like amyloid-beta and tau. Studies have yet to comprehensively explore the anti-aggregatory properties of arginine and CARPs on neurodegenerative disease-associated proteins.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Silvia Chaves, Katalin Varnagy, M. Amelia Santos
Summary: Alzheimer's disease is the most common and severe neurodegenerative disorder worldwide, with currently available drugs providing only temporary symptomatic relief. Research indicates that the onset and progression of AD are influenced by multiple factors, highlighting the need for the development of multitarget-directed ligands to target various pathological pathways.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Francesca Binacchi, Cassandra Elia, Damiano Cirri, Corjan van de Griend, Xue-Quan Zhou, Luigi Messori, Sylvestre Bonnet, Alessandro Pratesi, Tarita Biver
Summary: Metal compounds are attractive ligands for various nucleic acids. Five metal complexes with aminopyridyl-2,2'-bipyridine tetradentate ligands and quasi-planar geometry were studied for their binding to different nucleic acid molecules. The binding preferences and structural features of the metal complexes were analyzed using spectroscopy and melting methods.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Canil, Juan Gurruchaga-Pereda, Simona Braccini, Lorella Marchetti, Tiziana Funaioli, Fabio Marchetti, Alessandro Pratesi, Luca Salassa, Chiara Gabbiani
Summary: Photoactivatable Pt(IV) prodrugs have great potential as metal-based drugs due to their chemical inertness in oxidized form and selective targeting compared to Pt(II) compounds. A new Pt(IV) complex, soluble in water and unreactive until reduction, was synthesized. The complex exhibited rapid and efficient photoreduction with visible light, facilitated by a catalytic system based on flavin and NADH. The reactivity of the prodrug against biological targets was only observed after photoreduction to its Pt(II) analogue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ester Giorgi, Francesca Binacchi, Carlo Marotta, Damiano Cirri, Chiara Gabbiani, Alessandro Pratesi
Summary: Despite progress, cancer still poses challenges due to side effects, resistance, and poor selectivity of current metal-based therapies. New strategies reviewed include using heterobimetallic complexes containing different metal centers and conjugating metal complexes to target cancer cells. Examples of targeting organelles and the entire cancer cell were highlighted.
Article
Biochemistry & Molecular Biology
Damiano Cirri, Andrea Geri, Lara Massai, Michele Mannelli, Tania Gamberi, Francesca Magherini, Matteo Becatti, Chiara Gabbiani, Alessandro Pratesi, Luigi Messori
Summary: A panel of four novel gold(I) complexes, inspired by the clinically established gold drug auranofin, were prepared and characterized. The differences in their interactions with model proteins were analyzed, and their cytotoxic effects on ovarian cancer cells were quantitated. These novel gold complexes showed potential as effective anticancer agents.
Article
Chemistry, Inorganic & Nuclear
Carlo Marotta, Ester Giorgi, Francesca Binacchi, Damiano Cirri, Chiara Gabbiani, Alessandro Pratesi
Summary: The discovery of cisplatin's antineoplastic properties in 1965 renewed the interest in metal complexes for medicinal applications. Researchers have been studying safer and more effective alternatives to cisplatin, including platinum(IV)-based compounds. These compounds have attracted attention because they can be reduced in cells to activate the platinum center and offer advantages such as reducing side effects. This review summarizes the recent achievements in the field of Pt(IV) prodrugs.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
Mikel Bernabeu de Maria, Diego Tesauro, Filippo Prencipe, Michele Saviano, Luigi Messori, Christine Enjalbal, Ryszard Lobinski, Luisa Ronga
Summary: Methylmercury, mercury (II), and mercury (I) chlorides were found to react with vasopressin and its mono- and diselenium analogues to form various mercury-peptide adducts. The replacement of Cys by SeCys in vasopressin increased reactivity towards methylmercury, resulting in the formation of -Se/S-Hg-Se-bridged structures and subsequent demethylation of methylmercury. Competitive experiments showed that CH3HgCl preferred to react with the diselenium analogue rather than vasopressin. The diselenium peptide also demonstrated the ability to displace CH3Hg moieties bound to S in vasopressin. These findings suggest the potential use of selenopeptides for methylmercury chelation and detoxification strategies.
INORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Andrea Geri, Lara Massai, Luigi Messori
Summary: Gold compounds have shown promise as anticancer agents with innovative modes of action, targeting proteins rather than nucleic acids. Through ESI MS measurements, the reactions of various gold compounds with model proteins have been explored, revealing adduct formation and key features of these reactions. This review focuses on five gold compounds and their reactions with four biomolecular targets, showing that cytotoxic gold drugs selectively target cancer cell proteins, particularly cysteine and selenocysteine proteome, leading to severe damage and altered redox state, ultimately causing cancer cell death.
Article
Chemistry, Multidisciplinary
Andrea Geri, Lara Massai, Marko Novinec, Iztok Turel, Luigi Messori
Summary: Medicinal gold compounds exert their pharmacological effects by binding to protein targets. In this study, the reactions between seven representative gold compounds and the cysteine protease cathepsin B were explored, revealing strong interactions with the free cysteine in the enzyme. The findings suggest that the chemical nature of the gold compound plays a significant role in its interaction with proteins.
Article
Chemistry, Multidisciplinary
Veronica Ghini, Michele Mannelli, Lara Massai, Andrea Geri, Stefano Zineddu, Tania Gamberi, Luigi Messori, Paola Turano
Summary: NMR metabolomics is a valuable approach for studying changes in cancer cell metabolism caused by anticancer drugs. This study investigates the significant metabolic alterations induced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells and compares them to auranofin, providing insights into the underlying mechanisms.
Article
Chemistry, Inorganic & Nuclear
Gabriella Tito, Romualdo Troisi, Giarita Ferraro, Andrea Geri, Lara Massai, Luigi Messori, Filomena Sica, Antonello Merlino
Summary: The reaction between the cytotoxic compound dirhodium tetraacetate and a B-DNA double helical dodecamer was studied using X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct revealed a dimetallic center binding to an adenine through axial coordination. Additional information was obtained through ESI MS measurements. Comparison with previous data for cisplatin indicated a significant difference in the way these two metallodrugs react with the DNA dodecamer.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Lara Massai, Thomas Scattolin, Matteo Tarchi, Fabiano Visentin, Luigi Messori
Summary: By using ESI MS analysis, the interactions of four organopalladium agents with representative model proteins were explored, revealing that Pd allyl compounds exhibited modest reactivity with proteins, while palladacyclopentadienyl complex showed greater and unique reactivity.
Article
Chemistry, Inorganic & Nuclear
Damiano Cirri, Lara Massai, Chiara Giacomelli, Maria Letizia Trincavelli, Annalisa Guerri, Chiara Gabbiani, Luigi Messori, Alessandro Pratesi
Summary: A novel gold(i) complex AFETT was synthesized and found to have remarkable binding properties to human proteins, as well as strong cytotoxic effects on ovarian and colorectal cancer cells. AFETT exhibited distinctive features compared to auranofin, which could provide significant advantages in pharmaceutical and therapeutic applications.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Veronica Ghini, Francesca Magherini, Lara Massai, Luigi Messori, Paola Turano
Summary: This study used H-1 NMR metabolomics to analyze the metabolic changes in A2780 human ovarian cancer cells after treatment with Pt drugs (cisplatin, carboplatin, and oxaliplatin). The results showed moderate and consistent alterations in metabolomic profiles, highlighting the induction of endoplasmic reticulum stress.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)