Article
Biochemistry & Molecular Biology
Yaqian Dai, Tangni Fang, Yuanhong Xu, Taoshan Jiang, Jinping Qiao
Summary: A series of multi-fluorine labeled indanone derivatives were designed and synthesized for the early diagnosis of Alzheimer's disease (AD). Compound 7d showed high affinity with A beta plaques, low toxicity, and excellent imaging ability. It could provide a feasible solution for the early diagnosis of AD under non-radioactive condition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Truc T. Huynh, Yujue Wang, Karna Terpstra, Hong-Jun Cho, Liviu M. Mirica, Buck E. Rogers
Summary: This study introduces novel bifunctional chelators that can effectively bind with amyloid fibrosis and show promising potential for detecting and managing cerebral amyloid angiopathy.
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Jia Miao, Minqian Miao, Yue Jiang, Min Zhao, Qing Li, Yuan Zhang, Yi An, Kanyi Pu, Qingqing Miao
Summary: A NIR-II fluorescent reporter with a donor-pi-acceptor architecture was developed for specific detection of A beta plaques in AD-model mice, enabling non-invasive imaging and deep deciphering of AD progression.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Endocrinology & Metabolism
Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D. Gispert, Ronald Boellaard, Adriaan A. Lammertsma
Summary: This study evaluated the effects of global and regional cerebral blood flow changes on amyloid quantification using PET imaging. RLogan method was found to be the preferable choice for accurate quantification of amyloid load in [F-18]flutemetamol and [F-18]florbetaben studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Chemistry, Medicinal
Hao Xiao, Seok Rye Choi, Ruiyue Zhao, Karl Ploessl, David Alexoff, Lin Zhu, Zhihao Zha, Hank F. Kung
Summary: The highly deuterated PET imaging agent D15FSP showed excellent binding affinity to A beta plaques, lower bone uptake, and potential suitability for detecting A beta plaques.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
MiaoMiao Xu, Jun Guo, JiaCheng Gu, LinLin Zhang, ZiHao Liu, Lin Ding, HongLiang Fu, YuFei Ma, Sheng Liang, Hui Wang
Summary: A new Aβ tracer [F-18]DRKXH1 was synthesized and evaluated for its performance in diagnosing AD using various methods. The tracer showed promising results in detecting Aβ plaques in the brains of AD transgenic mice and AD patients, suggesting its potential for in vivo detection of the human brain.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Geriatrics & Gerontology
Yan Chang, Jiajin Liu, Liang Wang, Xin Li, Zhenjun Wang, Mu Lin, Wei Jin, Mingwei Zhu, Baixuan Xu
Summary: This study aimed to compare amyloid deposition in lobar cerebral microbleed (CMB) sites of cerebral amyloid angiopathy (CAA), Alzheimer's disease (AD), and cognitively normal healthy controls (NC), using an integrated C-11-Pittsburgh compound B (PIB) positron emission tomography (PET)/magnetic resonance (MR) approach. The results showed that the proposed method had a high accuracy in distinguishing CAA and AD patients, providing valuable insights into the pathogenesis of CMBs and the potential utility of PIB-PET/MR as a non-invasive diagnostic tool.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Jogender Mehla, Itender Singh, Deepti Diwan, James W. Nelson, Molly Lawrence, Eunjae Lee, Adam Q. Bauer, David M. Holtzman, Gregory J. Zipfel
Summary: Inhibition of STAT3 improved cognitive functions, cerebrovascular function, and amyloid pathology while reducing oxidative stress and neuroinflammation, potentially through reducing APP processing and attenuating LRP-1 oxidative modification. These findings highlight the therapeutic potential of STAT3 specific inhibition for the treatment of Alzheimer's disease and cerebral amyloid angiopathy.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Min Ho Jeon, Young-Do Kwon, Min Pyeong Kim, Gianluca Bartolini Torres, Jeong Kon Seo, Jeongmin Son, Young Hoon Ryu, Sung You Hong, Joong-Hyun Chun
Summary: The study presents a successful synthesis of various sulfamoyl [F-18]fluorides using an F-18/F-19 isotopic exchange approach, improving synthetic efficiency with radiochemical yields up to 97%. This late-stage labeling protocol offers an efficient route to diversify the chemical library possessing sulfamoyl functionalities by incorporating nucleophilic F-18 within nitrogen-containing sulfur(VI) frameworks.
Article
Biochemistry & Molecular Biology
Wei Zheng, Yong Huang, Hualong Chen, Zeng Jiang, Ziyue Yu, Tingyu Yang, Lu Zhang, Xuebo Cheng, Yajing Liu, Qi Liu, Xunming Ji, Zehui Wu
Summary: Accurate quantification of amyloid beta (AO') plaques is crucial for the diagnosis and treatment of Alzheimer's disease. New highly sensitive tracers, such as [18F]BIBD-124, were developed with improved clearance rates and lower in vivo defluorination compared to AV45. These tracers showed similar binding sites and imaging capabilities to AV45, with better imaging contrast and less nonspecific uptake. Based on these promising results, [18F]BIBD-124 is expected to be a potential radiotracer for further clinical trials.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Alexander P. Seiffert, Adolfo Gomez-Grande, Alberto Villarejo-Galende, Marta Gonzalez-Sanchez, Hector Bueno, Enrique J. Gomez, Patricia Sanchez-Gonzalez
Summary: Dynamic early-phase PET images using radiotracers binding to fibrillar amyloid-beta correlate with [F-18]fluorodeoxyglucose PET images and provide perfusion-like information. Regional standardized uptake value ratios and intrapatient Pearson's correlation coefficients show strong correlations between the dynamic early-phase PET images and [F-18]FDG PET images. This suggests that dynamic early-phase PET could serve as an additional neurodegeneration biomarker in amyloid PET studies.
Article
Physics, Multidisciplinary
Alejandro D. Arroyo, Andrea E. Guzman, Alexander Kachur, Anatoliy Popov, E. James Delikatny
Summary: This study presents functional fluorinated bioactivatable molecules for studying cancer metabolism using Cerenkov imaging. The synthesized MFRA showed the ability to differentiate between oxidized and reduced species via optical imaging with significant signal enhancement at 640 nm. The differential rates of MFRA reduction in different breast cancer cell lines and the potential application in assessing tumor metabolic features were demonstrated in this research.
FRONTIERS IN PHYSICS
(2021)
Article
Clinical Neurology
Jennifer S. Rabin, Emma Nichols, Renaud La Joie, Kaitlin B. Casaletto, Priya Palta, Kristen Dams-O'Connor, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie A. Schneider, Judy Pa, Adam M. Brickman
Summary: Accumulating data suggests that cerebrovascular disease contributes to the pathophysiology and progression of Alzheimer's disease. Cerebral amyloid angiopathy, characterized by the build-up of beta-amyloid in blood vessel walls, commonly co-occurs with Alzheimer's disease in the aging brain and increases the risk of dementia. This study found that cerebral amyloid angiopathy independently or interactively influences tau deposition and cognitive decline, and tau mediates the association between cerebral amyloid angiopathy and cognitive decline.
Review
Pharmacology & Pharmacy
Chao Wang, Rong Lin, Shaobo Yao
Summary: This review focuses on recent advances in the synthesis, radiolabeling, and application of a series of F-18-labeled amino acid analogs using new F-18-labeling strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyoko Kameyama Nakao, Aki Kido, Koji Fujimoto, Yoshitsugu Chigusa, Sachiko Minamiguchi, Masaki Mandai, Yuji Nakamoto
Summary: This study aimed to evaluate the prognostic capabilities of placental IVIM parameters and T2-relaxation time, and their correlation with fetal growth and adverse outcomes, comparing with umbilical artery pulsatility index (UmA-PI). The results showed that placental f and T2 value (Z-score) had significant associations with low birth weight and clinical adverse outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masao Watanabe, Kanae Kawai-Miyake, Yasutaka Fushimi, Takayoshi Ishimori, Aya Nakajima, Michio Yoshimura, Masahiro Kikuchi, Kazuko Ohno, Yuji Nakamoto
Summary: This study compared the qualitative and quantitative performance of fxPET with different attenuation correction methods to WB PET/CT. While fxPET showed inferior image quality compared to WB PET/CT, the detection rates and quantitative values indicated the clinical feasibility of fxPET.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Onishi, Hiroyoshi Isoda, Tsuyoshi Ohno, Hironori Shimizu, Kotaro Shimada, Kojiro Taura, Etsuro Hatano, Yuji Nakamoto
Summary: This study evaluated the future liver remnant (FLR) hypertrophy rate in patients undergoing portal vein embolization before left trisectionectomy, finding that PVE is effective in achieving FLR hypertrophy. The study also showed that PVE before left trisectionectomy was equally effective in patients with left portal vein stenosis or occlusion as compared to those without, with acceptable complication rates.
ABDOMINAL RADIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Wang, Li Cai, Kaixiang Zhou, Mengchao Cui, Shaobo Yao
Summary: This study reported a fully automated radiosynthetic procedure of a novel tau tracer [F-18]-S16 and evaluated its safety, biodistribution, and dosimetry in healthy volunteers as well as its potential utility in Alzheimer's disease (AD). The results showed that [F-18]-S16 could be synthesized automatically with favorable biodistribution and safety in humans. [F-18]-S16 PET demonstrated high image quality for imaging tau deposition in AD and distinguishing AD from healthy controls.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Yumi Yamamoto, Yi-Chu Liao, Yi-Chung Lee, Masafumi Ihara, Jay Chol Choi
Summary: CADASIL is the most common monogenic disorder of the cerebral small blood vessels, caused by mutations in the NOTCH3 gene. Recent large-scale genomic studies have revealed a high prevalence of pathogenic NOTCH3 variants among the general population, with the highest risk being among Asians. The exact pathogenesis of CADASIL remains unclear, despite various laboratory and clinical observations being made.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Instruments & Instrumentation
Mana Hosobuchi, Jun Kataoka, Hiromu Yokokawa, You Okazaki, Ryoichi Hirayama, Taku Inaniwa, Masashi Ueda, Mitsuhiro Kimura
Summary: Proton-boron capture therapy (pBCT) aims to enhance the efficacy of proton therapy by irradiating boron-accumulated cancer cells with protons. The biological efficacy of pBCT has been confirmed by cell-based experiments. However, the actual 3a reaction cross section is small and the effectiveness of pBCT needs further theoretical and experimental clarification.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Nutrition & Dietetics
Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara
Summary: The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) involves metabolic stress and inflammatory stimuli. In this study, we found that Taxifolin treatment effectively prevented hepatic steatosis, chronic inflammation, and liver fibrosis in a NASH murine model. Taxifolin inhibited lipid accumulation in hepatocytes and increased brown adipose tissue activity. Furthermore, Taxifolin treatment after NASH development could prevent the development of liver tumors. These findings indicate the pleiotropic effects of Taxifolin for NASH treatment.
Editorial Material
Biochemistry & Molecular Biology
Hiroyuki Ishiyama, Masafumi Ihara
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Chemistry, Medicinal
Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
Summary: We have discovered and developed a class of diaryl-azine derivatives for detecting Afi plaques in the AD brain using PET imaging. After comprehensive assessments, we identified a promising Afi-PET tracer, [18F]92, with high binding affinity to Afi aggregates, significant binding ability with AD brain sections, and optimal brain pharmacokinetic properties. The first in-human PET study showed that [18F]92 displayed low white matter uptake and could bind to Afi pathology for distinguishing AD from healthy controls, making it a promising PET tracer for visualizing Afi pathology in AD patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Masayo Iwasa, Hisashi Kato, Kaori Iwashita, Hajime Yamakage, Sayaka Kato, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Takayoshi Suganami, Masashi Tanaka, Noriko Satoh-Asahara
Summary: This study found that a high-glucose environment can increase intracellular reactive oxygen species (ROS) levels and trigger inflammation in microglial cells, leading to cognitive impairment in diabetes. However, taxifolin, a natural flavonoid, has been shown to reduce ROS levels and inhibit the activation of the TXNIP-NLRP3 axis, thereby suppressing inflammation and preventing cognitive impairment in diabetes.
Letter
Clinical Neurology
Yoshito Arakaki, Takeshi Yoshimoto, Hiroyuki Ishiyama, Tomotaka Tanaka, Yorito Hattori, Masafumi Ihara
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Health Care Sciences & Services
Satoshi Suda, Takehiro Katano, Kazuo Kitagawa, Yasuyuki Iguchi, Shigeru Fujimoto, Kenjiro Ono, Osamu Kano, Hidehiro Takekawa, Masatoshi Koga, Masafumi Ihara, Masafumi Morimoto, Hiroshi Yamagami, Tadashi Terasaki, Keiji Yamaguchi, Seiji Okubo, Yuji Ueno, Nobuyuki Ohara, Yuki Kamiya, Masataka Takeuchi, Yukako Yazawa, Yuka Terasawa, Ryosuke Doijiri, Yoshifumi Tsuboi, Kazutaka Sonoda, Koichi Nomura, Takashi Shimoyama, Akihito Kutsuna, Kazumi Kimura
Summary: This study aims to evaluate the proportion, timing, and characteristics of atrial fibrillation (AF) detection in patients with cryptogenic stroke (CS) using insertable cardiac monitors (ICMs). It also aims to compare patient characteristics and outcomes between those with AF and those without AF. The study has started and the main results are expected to be published in 2023. The findings of this study will contribute to the identification of AF markers and the development of a new and improved screening algorithm for AF detection, as well as aiding in the selection of patients for ICM implantation and the development of diagnostic criteria for CS in Japan.
JMIR RESEARCH PROTOCOLS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yuji Nakamoto, Shingo Baba, Hayato Kaida, Osamu Manabe, Tomoya Uehara
Summary: Positron emission tomography (PET) with fibroblast activation protein inhibitor (FAPI) has gained attention as a promising tumor diagnostic imaging tool with comparable or superior accuracy to 18F-fluorodeoxyglucose (FDG) PET. FAPI PET can accurately depict most malignant tumors and identify lesions inconclusive on FDG PET. There are also reports suggesting the utility of FAPI PET in non-neoplastic conditions. Multiple radiopharmaceutical FAPIs have been developed with potential therapeutic efficacy.
ANNALS OF NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Takehito Kuroda, Tomotaka Tanaka, Soichiro Abe, Manabu Inoue, Yoshiaki Morita, Takuto Mukaida, Takamasa Iwai, Masafumi Ihara
EPILEPTIC DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Onishi, Hironori Shimizu, Shojiro Oka, Takanori Taniguchi, Seiya Kawahara, Yukio Ishisaka, Hiroyoshi Isoda, Yuji Nakamoto
Summary: The study evaluated the technical and clinical success rates of transcatheter arterial embolization (TAE) for subcapsular hematoma of the liver. The results showed that TAE is an effective and safe treatment for subcapsular hematomas of the liver. The success rates of TAE and liver damage due to TAE did not differ between patients with and without retrograde portal venous flow.
ABDOMINAL RADIOLOGY
(2023)
