Imaging agents for the chemokine receptor 4 (CXCR4)

Immunohistochemical Detection of the CXCR4 Expression in Tumor Tissue Using the Fluorescent Peptide Antagonist Ac-TZ14011-FITC

(2014) Nynke S. van den Berg et al.   Translational Oncology

Synthesis and in vitro evaluation of 68Ga-DOTA-4-FBn-TN14003, a novel tracer for the imaging of CXCR4 expression

(2012) Ute Hennrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: New insight into CXCR4–FC131 interactions

(2012) Yasushi Yoshikawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Somatostatin receptor SPECT

(2012) Giovanna Pepe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development of novel CXCR4-based therapeutics

(2012) Amnon Peled et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Structure–Activity Relationship Study of a CXC Chemokine Receptor Type 4 Antagonist, FC131, Using a Series of Alkene Dipeptide Isosteres

(2012) Kazuya Kobayashi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Unique Small Molecule Modulator of CXCR4

(2012) Zhongxing Liang et al.   PLoS One

PET imaging of CXCR4 using copper-64 labeled peptide antagonist

(2012) Orit Jacobson et al.   Theranostics

Synthesis and Evaluation of a Bimodal CXCR4 Antagonistic Peptide

(2011) Joeri Kuil et al.   BIOCONJUGATE CHEMISTRY

Targeted non-covalent self-assembled nanoparticles based on human serum albumin

(2011) Anton Bunschoten et al.   BIOMATERIALS

Concise site-specific synthesis of DTPA–peptide conjugates: Application to imaging probes for the chemokine receptor CXCR4

(2011) Ryo Masuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

(2011) Renato Skerlj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How I treat patients who mobilize hematopoietic stem cells poorly

(2011) L. B. To et al.   BLOOD

Evaluation of a Fluorescent Derivative of AMD3100 and its Interaction with the CXCR4 Chemokine Receptor

(2011) James C. Knight et al.   CHEMBIOCHEM

Peptide-Functionalized Luminescent Iridium Complexes for Lifetime Imaging of CXCR4 Expression

(2011) Joeri Kuil et al.   CHEMBIOCHEM

Strategies for in vivo imaging of enzyme activity: an overview and recent advances

(2011) Andrew Razgulin et al.   CHEMICAL SOCIETY REVIEWS

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

(2011) Chien-Huang Wu et al.   ChemMedChem

Azamacrocyclic Metal Complexes as CXCR4 Antagonists

(2011) Tomohiro Tanaka et al.   ChemMedChem

PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand

(2011) Oliver Demmer et al.   ChemMedChem

Stromal Cell-Derived Factor-1 Retention and Cardioprotection for Ischemic Myocardium

(2011) Sachiko Kanki et al.   Circulation-Heart Failure

Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7

(2011) Manuela Meincke et al.   CLINICAL & EXPERIMENTAL METASTASIS

The CXCL12/CXCR4 Axis as a Therapeutic Target in Cancer and HIV-1 Infection

(2011) L. Patrussi et al.   CURRENT MEDICINAL CHEMISTRY

Radiometallated peptides for molecular imaging and targeted therapy

(2011) João D. G. Correia et al.   DALTON TRANSACTIONS

Plerixafor

(2011) Gillian M. Keating   DRUGS

Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists

(2011) Sameer P Kawatkar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Small molecule HIV entry inhibitors: Part I. Chemokine receptor antagonists: 2004 – 2010

(2011) Inder Pal Singh et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Potential of CXCR4 antagonists for the treatment of metastatic lung cancer

(2011) Jan A Burger et al.   Expert Review of Anticancer Therapy

Detection of CXCR4 receptors on cell surface using a fluorescent metal nanoshell

(2011) Jian Zhang et al.   JOURNAL OF BIOMEDICAL OPTICS

Improvement of CXCR4 tracer specificity for PET imaging

(2011) Orit Jacobson et al.   JOURNAL OF CONTROLLED RELEASE

Drug Discovery Research Targeting the CXC Chemokine Receptor 4 (CXCR4)

(2011) Won-Tak Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4

(2011) Oliver Demmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

CXCR4-Based Imaging Agents

(2011) L. E. Woodard et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging CXCR4 Expression in Human Cancer Xenografts: Evaluation of Monocyclam 64Cu-AMD3465

(2011) R. A. De Silva et al.   JOURNAL OF NUCLEAR MEDICINE

PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent

(2011) E. Gourni et al.   JOURNAL OF NUCLEAR MEDICINE

Direct Interaction between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4

(2011) Jay M. Janz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CXCR4 Overexpression Is Associated with Poor Outcome in Females Diagnosed with Stage IV Non-small Cell Lung Cancer

(2011) Shannon Otsuka et al.   Journal of Thoracic Oncology

Positron Emission Tomography Imaging of Tumors Expressing the Human Chemokine Receptor CXCR4 in Mice with the Use of 64Cu-AMD3100

(2011) Ido D. Weiss et al.   MOLECULAR IMAGING AND BIOLOGY

Hybrid Peptide Dendrimers for Imaging of Chemokine Receptor 4 (CXCR4) Expression

(2011) Joeri Kuil et al.   MOLECULAR PHARMACEUTICS

In vivo imaging of ligand receptor binding with Gaussia luciferase complementation

(2011) Kathryn E Luker et al.   NATURE MEDICINE

Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis

(2011) Eriko Inokuchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokine receptor CXCR4 overexpression predicts recurrence for hormone receptor-positive, node-negative breast cancer patients

(2011) Quyen D. Chu et al.   SURGERY

Potent CXCR4 Antagonists Containing Amidine Type Peptide Bond Isosteres

(2011) Eriko Inokuchi et al.   ACS Medicinal Chemistry Letters

Agonists for the Chemokine Receptor CXCR4

(2011) Marilou Lefrançois et al.   ACS Medicinal Chemistry Letters

Novel Compounds Containing Multiple Guanide Groups That Bind the HIV Coreceptor CXCR4

(2010) Royce A. Wilkinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide-Based Probes for Targeted Molecular Imaging

(2010) Seulki Lee et al.   BIOCHEMISTRY

Multimodal Tumor-Targeting Peptides Functionalized with Both a Radio- and a Fluorescent Label

(2010) Joeri Kuil et al.   BIOCONJUGATE CHEMISTRY

CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist

(2010) Tetsuo Narumi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

(2010) Renato Skerlj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Imaging of CXCR4 Receptor Expression in Human Cancer Xenografts with [64Cu]AMD3100 Positron Emission Tomography

(2010) S. Nimmagadda et al.   CANCER RESEARCH

Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis

(2010) Seulki Lee et al.   CHEMICAL REVIEWS

Molecular tracers for the PET and SPECT imaging of disease

(2010) Sally L. Pimlott et al.   CHEMICAL SOCIETY REVIEWS

Novel Monocyclam Derivatives as HIV Entry Inhibitors: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with the CXCR4 Co-receptor

(2010) Sofia Pettersson et al.   ChemMedChem

99mTc–AMD3100: A novel potential receptor-targeting radiopharmaceutical for tumor imaging

(2010) Jin Ming Zhang et al.   CHINESE CHEMICAL LETTERS

Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer

(2010) Balraj Singh et al.   CLINICAL & EXPERIMENTAL METASTASIS

Concomitant CXCR4 and CXCR7 Expression Predicts Poor Prognosis in Renal Cancer

(2010) C. D'Alterio et al.   CURRENT CANCER DRUG TARGETS

Update on clinical experience with AMD3100, an SDF-1/CXCL12–CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells

(2010) Iskra Pusic et al.   CURRENT OPINION IN HEMATOLOGY

The Cyclic Pentapeptide d-Arg3FC131, a CXCR4 Antagonist, Induces Apoptosis of Somatotrope Tumor and Inhibits Tumor Growth in Nude Mice

(2010) Jeong Mo Kim et al.   ENDOCRINOLOGY

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model

(2010) Saima Hassan et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear expression of CXCR4 is associated with advanced colorectal cancer

(2010) Shang-Chiung Wang et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis

(2010) Yixin Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity

(2010) Aizhi Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

(2010) Renato T. Skerlj et al.   JOURNAL OF MEDICINAL CHEMISTRY

PET of Tumor CXCR4 Expression with 4-18F-T140

(2010) O. Jacobson et al.   JOURNAL OF NUCLEAR MEDICINE

The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma

(2010) Tong Li et al.   JOURNAL OF PATHOLOGY

Synthesis and preliminary evaluation of a novel 125I-labeled T140 analog for quantitation of CXCR4 expression

(2010) Yanjiang Han et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells

(2010) Tomohiro Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting SDF-1/CXCL12 with a Ligand That Prevents Activation of CXCR4 through Structure-Based Drug Design

(2010) Christopher T. Veldkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody–ProteinA conjugated quantum dots for multiplexed imaging of surface receptors in living cells

(2010) Takashi Jin et al.   Molecular BioSystems

CXCR4 and cancer

(2010) Bungo Furusato et al.   PATHOLOGY INTERNATIONAL

Immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions

(2010) Xin He et al.   PATHOLOGY RESEARCH AND PRACTICE

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

(2010) B. Tchernychev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

High-Level CXCR4 Expression Correlates with Brain-Specific Metastasis of Non-Small Cell Lung Cancer

(2010) Gang Chen et al.   WORLD JOURNAL OF SURGERY

Bombesin Receptor-Mediated Imaging and Cytotoxicity: Review and Current Status

(2010) Veronica Sancho et al.   Current Drug Delivery

Tumor Imaging and Therapy Using Radiolabeled Somatostatin Analogues

(2009) Marion de Jong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ligands for Mapping αvβ3-Integrin Expression in Vivo

(2009) Margret Schottelius et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Influence of Tumor-Host Interactions in the Stromal Cell-Derived Factor-1/CXCR4 Ligand/Receptor Axis in Determining Metastatic Risk in Breast Cancer

(2009) Saima Hassan et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications

(2009) N. Cabioglu et al.   ANNALS OF ONCOLOGY

Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma

(2009) Masaru Ueda et al.   AURIS NASUS LARYNX

The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil)

(2009) Erik De Clercq   BIOCHEMICAL PHARMACOLOGY

64Cu-AMD3100—A novel imaging agent for targeting chemokine receptor CXCR4

(2009) Orit Jacobson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7

(2009) Kathryn E. Luker et al.   BIOTECHNIQUES

High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma

(2009) R Maréchal et al.   BRITISH JOURNAL OF CANCER

New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

(2009) Hisataka Kobayashi et al.   CHEMICAL REVIEWS

Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis

(2009) Linhui Wang et al.   CLINICAL & EXPERIMENTAL METASTASIS

The role of stromal-derived factor-1 — CXCR7 axis in development and cancer

(2009) Radoslaw B. Maksym et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4

(2009) Koji Nishizawa et al.   INTERNATIONAL JOURNAL OF CANCER

Divergent Oriented Synthesis For the Design of Reagents for Protein Conjugation

(2009) Elisabeth Garanger et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Immunoimaging of CXCR4 Expression in Brain Tumor Xenografts Using SPECT/CT

(2009) S. Nimmagadda et al.   JOURNAL OF NUCLEAR MEDICINE

Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes

(2009) Abid Khan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular imaging targeting peptide receptors

(2009) Margret Schottelius et al.   METHODS

Peptide receptor imaging of prostate cancer with radiolabelled bombesin analogues

(2009) R.P.J. Schroeder et al.   METHODS

An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells

(2009) J. Kwong et al.   MOLECULAR CANCER THERAPEUTICS

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence

(2009) F. Andre et al.   ONCOLOGIST

Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

(2009) Tetsuo Narumi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth

(2009) Stacy Porvasnik et al.   PROSTATE

Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis

(2009) Toshihiro Nanki et al.   ARTHRITIS RESEARCH & THERAPY

Imaging CXCR4 Signaling with Firefly Luciferase Complementation

(2008) Kathryn E. Luker et al.   ANALYTICAL CHEMISTRY

The Chemokine Receptors CXCR4 and CCR7 are Associated with Tumor Size and Pathologic Indicators of Tumor Aggressiveness in Papillary Thyroid Carcinoma

(2008) Patrick L. Wagner et al.   ANNALS OF SURGICAL ONCOLOGY

Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4−Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening

(2008) Wataru Nomura et al.   BIOCONJUGATE CHEMISTRY

CxCR4 Membrane Expression in Node-Negative Breast Cancer

(2008) Emmanuel Blot et al.   Breast Journal

Imaging of integrin αvβ3 expression

(2008) Ambros J. Beer et al.   CANCER AND METASTASIS REVIEWS

Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

(2008) Takuya Akashi et al.   CANCER SCIENCE

Synthesis and Application of Fluorescein- and Biotin-Labeled Molecular Probes for the Chemokine Receptor CXCR4

(2008) Shinya Oishi et al.   CHEMBIOCHEM

CXCR4, Inhibitors and Mechanisms of Action

(2008) Xiangyang Liang   Chemical Biology & Drug Design

Simplified syntheses of complex multifunctional nanomaterials

(2008) Elisabeth Garanger et al.   CHEMICAL COMMUNICATIONS

Activatable imaging probes with amplified fluorescent signals

(2008) Seulki Lee et al.   CHEMICAL COMMUNICATIONS

Translating an Antagonist of Chemokine Receptor CXCR4: From Bench to Bedside

(2008) D. Wong et al.   CLINICAL CANCER RESEARCH

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Nuclear expression of CXCR4 in tumor cells of non–small cell lung cancer is correlated with lymph node metastasis

(2008) Il-Kang Na et al.   HUMAN PATHOLOGY

Tumor Receptor Imaging

(2008) D. A. Mankoff et al.   JOURNAL OF NUCLEAR MEDICINE

Quantitation of CXCR4 Expression in Myocardial Infarction Using 99mTc-Labeled SDF-1 

(2008) P. Misra et al.   JOURNAL OF NUCLEAR MEDICINE

A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer

(2008) Eugene H. Huang et al.   JOURNAL OF SURGICAL RESEARCH

Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors

(2008) R. S. Y. Wong et al.   MOLECULAR PHARMACOLOGY

Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026

(2008) G. Moncunill et al.   MOLECULAR PHARMACOLOGY

CXCR4 Expression is Elevated in Glioblastoma Multiforme and Correlates with an Increase in Intensity and Extent of Peritumoral T2-weighted Magnetic Resonance Imaging Signal Abnormalities

(2008) Charles B. Stevenson et al.   NEUROSURGERY

Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore

(2008) Tomohiro Tanaka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Introduction of Functional Groups into Peptides viaN-Alkylation

(2008) O. Demmer et al.   ORGANIC LETTERS

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study

(2008) Kristin Andreas et al.   ARTHRITIS RESEARCH & THERAPY

Strong Expression of Chemokine ReceptorCXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease

(2008) Thomas C. Wehler et al.   Journal of Oncology