Development of novel CXCR4-based therapeutics

Progenitor Cell Mobilization Enhances Bone Healing by Means of Improved Neovascularization and Osteogenesis

(2011) Xiao Xia Wang et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

(2010) M. Buchner et al.   BLOOD

Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-hodgkin's lymphoma or multiple myeloma

(2010) Michael Steinberg et al.   CLINICAL THERAPEUTICS

CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts

(2010) Begoña Santiago et al.   CYTOKINE

CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth

(2010) Katia Beider et al.   EXPERIMENTAL HEMATOLOGY

AMD3100 is a potent antagonist at CXCR4R334X, a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

(2010) David H. McDermott et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

(2010) Renato T. Skerlj et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells

(2010) Tomohiro Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis

(2010) Soo-Hyun Chung et al.   ARTHRITIS RESEARCH & THERAPY

The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies with AMD3100

(2009) T. Murakami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Blockade of X4-Tropic HIV-1 Cellular Entry by GSK812397, a Potent Noncompetitive CXCR4 Receptor Antagonist

(2009) S. Jenkinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406

(2009) M. P. Quiroga et al.   BLOOD

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

(2009) J. W. Friedberg et al.   BLOOD

A novel CXCR4 antagonist derived from human SDF-1β enhances angiogenesis in ischaemic mice

(2009) Yi Tan et al.   CARDIOVASCULAR RESEARCH

The role of stromal-derived factor-1 — CXCR7 axis in development and cancer

(2009) Radoslaw B. Maksym et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma

(2009) John F. DiPersio et al.   JOURNAL OF CLINICAL ONCOLOGY

The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation

(2009) M Abraham et al.   LEUKEMIA

An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells

(2009) J. Kwong et al.   MOLECULAR CANCER THERAPEUTICS

Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1

(2009) Samantha J. Allen et al.   PROTEIN EXPRESSION AND PURIFICATION

NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity

(2008) Aviva Lapidot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Impact of Mobilization and Remobilization Strategies on Achieving Sufficient Stem Cell Yields for Autologous Transplantation

(2008) Iskra Pusic et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION