How I treat patients who mobilize hematopoietic stem cells poorly

Lenalidomide Restrains Motility and Overangiogenic Potential of Bone Marrow Endothelial Cells in Patients with Active Multiple Myeloma

(2011) A. De Luisi et al.   CLINICAL CANCER RESEARCH

Hierarchy of immature hematopoietic cells related to blood flow and niche

(2011) Jean-Pierre Lévesque et al.   CURRENT OPINION IN HEMATOLOGY

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

(2011) A Dar et al.   LEUKEMIA

Treatment with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone combined with cytarabine and methotrexate results in poor mobilization of peripheral blood stem cells in patients with mantle cell lymphoma

(2011) Brian T. Hill et al.   LEUKEMIA & LYMPHOMA

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

Development and validation of a decision-making algorithm to guide the use of plerixafor for autologous hematopoietic stem cell mobilization

(2010) L J Costa et al.   BONE MARROW TRANSPLANTATION

Predicting PBSC harvest failure using circulating CD34 levels: developing target-based cutoff points for early intervention

(2010) S Sinha et al.   BONE MARROW TRANSPLANTATION

review: Current status of stem cell mobilization

(2010) Morie A. Gertz   BRITISH JOURNAL OF HAEMATOLOGY

Mobilization of CD34+ cells by glycosylated and nonglycosylated G-CSF in healthy volunteers - a comparative study

(2010) M. Höglund et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34+ cell collection yield after administration of granulocyte colony-stimulating factor to healthy donors

(2010) B. Martin-Antonio et al.   HAEMATOLOGICA

Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex

(2010) M Z Ratajczak et al.   LEUKEMIA

Systemic signals regulate ageing and rejuvenation of blood stem cell niches

(2010) Shane R. Mayack et al.   NATURE

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization

(2010) Marnie A Ryan et al.   NATURE MEDICINE

Changes of cytokine levels during granulocyte-colony-stimulating factor stem cell mobilization in healthy donors: association with mobilization efficiency and potential predictive significance

(2010) Daniel Lysák et al.   TRANSFUSION

Poor hematopoietic stem cell mobilizers: A single institution study of incidence and risk factors in patients with recurrent or relapsed lymphoma

(2009) Chitra Hosing et al.   AMERICAN JOURNAL OF HEMATOLOGY

Treatment with Plerixafor in non-Hodgkin's Lymphoma and Multiple Myeloma Patients to Increase the Number of Peripheral Blood Stem Cells When Given a Mobilizing Regimen of G-CSF: Implications for the Heavily Pretreated Patient

(2009) Patrick Stiff et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

(2009) P. Ramirez et al.   BLOOD

Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens

(2009) S. Kumar et al.   BLOOD

Dysregulation of bone remodeling by imatinib mesylate

(2009) K. Vandyke et al.   BLOOD

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

(2009) A. Kohler et al.   BLOOD

The CXCL12-3′A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation

(2009) K Bogunia-Kubik et al.   BONE MARROW TRANSPLANTATION

Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma

(2009) John F. DiPersio et al.   JOURNAL OF CLINICAL ONCOLOGY

Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes

(2009) H M Lee et al.   LEUKEMIA

TRANSPLANTATION AND CELLULAR ENGINEERING: Increasing the economic efficacy of peripheral blood progenitor cell collections by monitoring peripheral blood CD34+ concentrations

(2009) Kai Gutensohn et al.   TRANSFUSION

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD

Plasmin therapy enhances mobilization of HPCs after G-CSF

(2008) M. Tjwa et al.   BLOOD

Telomere maintenance and human bone marrow failure

(2008) R. T. Calado et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

(2008) Daniel Lucas et al.   Cell Stem Cell

Stem cell factor and high-dose twice daily filgrastim is an effective strategy for peripheral blood stem cell mobilization in patients with indolent lymphoproliferative disorders previously treated with fludarabine: results of a Phase II study with an historical comparator

(2008) K E Herbert et al.   LEUKEMIA

Preferential sensitivity of hematopoietic (HPs) and mesenchymal (MPs) progenitors to fludarabine suggests impaired bone marrow niche and HP mobilization

(2008) M G Berger et al.   LEUKEMIA

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE