SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

(2017) Xiangpeng Dai et al.   NATURE MEDICINE

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

(2017) Pingzhao Zhang et al.   NATURE MEDICINE

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

(2017) Hana Janouskova et al.   NATURE MEDICINE

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

(2017) Xiaofeng Jin et al.   PLoS Genetics

Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer

(2016) Zhong-Qiang Guo et al.   CANCER CELL

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing

(2016) Kun Zhu et al.   NUCLEIC ACIDS RESEARCH

Cyclin E Deregulation Promotes Loss of Specific Genomic Regions

(2015) Leonardo K. Teixeira et al.   CURRENT BIOLOGY

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

(2015) Wenjian Gan et al.   MOLECULAR CELL

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

(2014) Guoqiang Li et al.   CANCER CELL

Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer

(2014) C. Geng et al.   CANCER RESEARCH

The emerging role of speckle-type POZ protein (SPOP) in cancer development

(2014) Ram-Shankar Mani   DRUG DISCOVERY TODAY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Similar, not the same

(2013) Loredana Spoerri et al.   CELL CYCLE

Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice

(2013) Wei Hu et al.   HEPATOLOGY

Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression

(2013) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrated view of cyclin E function and regulation

(2012) Ka Tat Siu et al.   CELL CYCLE

Fbw7  and Fbw7  Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation

(2012) N. Bhaskaran et al.   MOLECULAR AND CELLULAR BIOLOGY

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer

(2009) J. Liu et al.   SCIENCE