Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain

The Zebrafish: A Model to Study the Endogenous Mechanisms of Pain

(2013) V. Gonzalez-Nunez et al.   ILAR JOURNAL

Pain Perception in Fish: Indicators and Endpoints

(2013) L. U. Sneddon   ILAR JOURNAL

Assay sensitivity and study features in neuropathic pain trials: An ACTTION meta-analysis

(2013) R. H. Dworkin et al.   NEUROLOGY

A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy

(2013) Wenlong Huang et al.   PAIN

Animal models of bone cancer pain: Systematic review and meta-analyses

(2013) Gillian L. Currie et al.   PAIN

Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs

(2013) Roy Freeman et al.   PAIN

Expect analgesic failure; pursue analgesic success

(2013) A. Moore et al.   BMJ-British Medical Journal

Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials

(2013) Beverly S. Muhlhausler et al.   PLOS BIOLOGY

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Efficacy of Early Treatment with Carbamazepine in Prevention of Neuropathic Pain in Patients with Spinal Cord Injury

(2012) Fabio A. Salinas et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Gabapentin Inhibits γ-Amino Butyric Acid Release in the Locus Coeruleus but Not in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rats

(2012) Masaru Yoshizumi et al.   ANESTHESIOLOGY

Pro-sociality without empathy

(2012) M. Vasconcelos et al.   Biology Letters

Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain

(2012) T.S. Hahm et al.   BRITISH JOURNAL OF ANAESTHESIA

Drosophila as a tool for studying the conserved genetics of pain

(2012) G Milinkeviciute et al.   CLINICAL GENETICS

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

Effects of ethnicity and gender role expectations of pain on experimental pain: A cross-cultural study

(2012) O.A. Alabas et al.   EUROPEAN JOURNAL OF PAIN

Murine Immunodeficiency Virus-Induced Peripheral Neuropathy and the Associated Cytokine Responses

(2012) L. Cao et al.   JOURNAL OF IMMUNOLOGY

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

(2012) L. Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Spinal Mechanism Underlying the Antiallodynic Effect of Gabapentin Studied in the Mouse Spinal Nerve Ligation Model

(2012) Shin-ichi Morimoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats

(2012) Anne K. Schreiber et al.   NEUROPHARMACOLOGY

Inflammation-induced decrease in voluntary wheel running in mice: A nonreflexive test for evaluating inflammatory pain and analgesia

(2012) Enrique J. Cobos et al.   PAIN

Microneurography: Towards a biomarker of spontaneous pain

(2012) Jordi Serra   PAIN

Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy

(2012) Claudia M. Campbell et al.   PAIN

The Assessment of Post-Vasectomy Pain in Mice Using Behaviour and the Mouse Grimace Scale

(2012) Matthew C. Leach et al.   PLoS One

Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons

(2012) Wei Sun et al.   PLoS One

Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses

(2012) Stephanie C. J. Keating et al.   PLoS One

Macrophage-Mediated Dorsal Root Ganglion Damage Precedes Altered Nerve Conduction in SIV-Infected Macaques

(2011) Victoria A. Laast et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

(2011) Nick Andrews et al.   Annals of the New York Academy of Sciences

Predictive validity of behavioural animal models for chronic pain

(2011) Odd-Geir Berge   BRITISH JOURNAL OF PHARMACOLOGY

Hedgehog Signaling Regulates Nociceptive Sensitization

(2011) Daniel T. Babcock et al.   CURRENT BIOLOGY

Assessing symptom profiles in neuropathic pain clinical trials: Can it improve outcome?

(2011) Nadine Attall et al.   EUROPEAN JOURNAL OF PAIN

Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain

(2011) N. Andrews et al.   EUROPEAN JOURNAL OF PAIN

Dose Reduction of Meloxicam in Dogs with Osteoarthritis-Associated Pain and Impaired Mobility

(2011) B.G.J. Wernham et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

The Rat Grimace Scale: A Partially Automated Method for Quantifying Pain in the Laboratory Rat via Facial Expressions

(2011) Susana G Sotocina et al.   Molecular Pain

The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries

(2011) F.Y. Zheng et al.   NEUROSCIENCE

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Dopamine agonists in animal models of Parkinson’s disease: A systematic review and meta-analysis

(2011) Evelien D.M. Rooke et al.   PARKINSONISM & RELATED DISORDERS

The Development of New Analgesics Over the Past 50 Years: A Lack of Real Breakthrough Drugs

(2010) Igor Kissin   ANESTHESIA AND ANALGESIA

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

(2010) G. Gregory Neely et al.   CELL

The discovery and development of analgesics: new mechanisms, new modalities

(2010) Gillian Burgess et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of a Therapeutic Diet for Feline Degenerative Joint Disease

(2010) B.D.X. Lascelles et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Hypolocomotion, Asymmetrically Directed Behaviors (Licking, Lifting, Flinching, and Shaking) and Dynamic Weight Bearing (Gait) Changes are Not Measures of Neuropathic Pain in Mice

(2010) Jeffrey S Mogil et al.   Molecular Pain

Improving the translational hit of experimental treatments in multiple sclerosis

(2010) Hanna M Vesterinen et al.   Multiple Sclerosis Journal

Coding of facial expressions of pain in the laboratory mouse

(2010) Dale J Langford et al.   NATURE METHODS

Placebo and treatment group responses in postherpetic neuralgia vs. painful diabetic peripheral neuropathy clinical trials in the REPORT database

(2010) Robert H. Dworkin et al.   PAIN

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies

(2010) Marieke Niesters et al.   PAIN

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

The necessity of animal models in pain research

(2010) Jeffrey S. Mogil et al.   PAIN

Pharmacological Treatment of Painful HIV-Associated Sensory Neuropathy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

(2010) Tudor J. C. Phillips et al.   PLoS One

Burrowing Behavior as an Indicator of Post-Laparotomy Pain in Mice

(2010) Paulin Jirkof et al.   Frontiers in Behavioral Neuroscience

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Sex-Specific Responses to Opiates: Animal and Human Studies

(2009) Albert Dahan et al.   ANESTHESIA AND ANALGESIA

Burrowing: A sensitive behavioural assay, tested in five species of laboratory rodents

(2009) R.M.J. Deacon   BEHAVIOURAL BRAIN RESEARCH

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

A rat is not a monkey is not a human: comment on Mogil (Nature Rev. Neurosci. 10, 283–294 (2009))

(2009) A. D. Craig   NATURE REVIEWS NEUROSCIENCE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Development and characterization of a hemorrhagic rat model of central post-stroke pain

(2009) J.K. Wasserman et al.   NEUROSCIENCE

Effect of high trait anxiety on mechanical hypersensitivity in male rats

(2009) Kerstin Roeska et al.   NEUROSCIENCE LETTERS

Animal models of chemotherapy-evoked painful peripheral neuropathies

(2009) Nicolas Authier et al.   Neurotherapeutics

Comment on: Animal models and the prediction of efficacy in clinical trials of analgesic drugs: A critical appraisal and a call for uniform reporting standards

(2009) Steve N. Quessy   PAIN

The case for publishing ‘negative’ clinical trials

(2009) Michael C. Rowbotham   PAIN

Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833

(2009) Bing Hu et al.   PAIN

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Predictive validity of animal pain models? A comparison of the pharmacokinetic–pharmacodynamic relationship for pain drugs in rats and humans

(2008) G.T. Whiteside et al.   NEUROPHARMACOLOGY

Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain

(2008) Victoria C.J. Wallace et al.   NEUROSCIENCE LETTERS

Animal models and the prediction of efficacy in clinical trials of analgesic drugs: A critical appraisal and call for uniform reporting standards

(2008) Andrew S.C. Rice et al.   PAIN

Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin

(2008) Kerstin Roeska et al.   PAIN

Clinical and pre-clinical pain assessment: Are we measuring the same thing?

(2008) C. J. Vierck et al.   PAIN

A Novel Approach to the Use of Animals in Studies of Pain: Validation of the Canine Brief Pain Inventory in Canine Bone Cancer

(2008) Dorothy Cimino Brown et al.   PAIN MEDICINE

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

(2008) Malcolm R. Macleod et al.   STROKE

Good Laboratory Practice

(2008) Malcolm R. Macleod et al.   STROKE

The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy

(2007) V C J Wallace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sciatic nerve cuffing in mice: A model of sustained neuropathic pain

(2007) Malika Benbouzid et al.   EUROPEAN JOURNAL OF PAIN

Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations

(2007) Robert H. Dworkin et al.   JOURNAL OF PAIN

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN