The discovery and development of analgesics: new mechanisms, new modalities

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminalsin vivo: Figure 1

(2010) Claudia S. Bauer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacological Management of Low Back Pain

(2010) Roger Chou   DRUGS

Importance of Side Effects in Opioid Treatment: A Trade-Off Analysis With Patients and Physicians

(2010) Razmic S. Gregorian et al.   JOURNAL OF PAIN

Long-Term Safety of NGX-4010, a High-Concentration Capsaicin Patch, in Patients with Peripheral Neuropathic Pain

(2010) David M. Simpson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

(2010) G. M. Lipkind et al.   MOLECULAR PHARMACOLOGY

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Sodium channelopathies and pain

(2010) Angelika Lampert et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The  2  subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

(2010) A. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Examining the roles of cannabinoids in pain and other therapeutic indications: a review

(2009) Dana Turcotte et al.   EXPERT OPINION ON PHARMACOTHERAPY

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

(2009) P Rolan et al.   EXPERT OPINION ON PHARMACOTHERAPY

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

(2009) Roger Chou et al.   JOURNAL OF PAIN

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glial cells on the radar

(2009) Cormac Sheridan   NATURE BIOTECHNOLOGY

Current Challenges in Glia-Pain Biology

(2009) Stephen B. McMahon et al.   NEURON

Sodium channel blockers for the treatment of neuropathic pain

(2009) Anindya Bhattacharya et al.   Neurotherapeutics

NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin

(2009) Roman Rukwied et al.   PAIN

Keratinocytes acting on injured afferents induce extreme neuronal hyperexcitability and chronic pain

(2009) Christine Radtke et al.   PAIN

CNSB004 (Leconotide) Causes Antihyperalgesia Without Side Effects When Given Intravenously: A Comparison with Ziconotide in a Rat Model of Diabetic Neuropathic Pain

(2009) Anton Kolosov et al.   PAIN MEDICINE

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

(2009) A. A. Romanovsky et al.   PHARMACOLOGICAL REVIEWS

Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets

(2009) Gordon Munro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting Nerve Growth Factor in Pain

(2008) Judy J Watson et al.   BIODRUGS

Voltage-gated sodium channels: the search for subtype-selective analgesics

(2008) Steve England   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Managing neuropathic pain with Sativex®: a review of its pros and cons

(2008) Jordi Perez et al.   EXPERT OPINION ON PHARMACOTHERAPY

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

(2008) Nuria Tamayo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study

(2008) Miroslav Backonja et al.   LANCET NEUROLOGY

Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy

(2008) D. M. Simpson et al.   NEUROLOGY

Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection

(2008) V.L. Tawfik et al.   NEUROSCIENCE

Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat

(2008) Young Seob Gwak et al.   PAIN

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early experience with lidocaine patch for postoperative pain control after laparoscopic ventral hernia repair

(2008) Alan A. Saber et al.   International Journal of Surgery