Article
Immunology
Yuting Tan, Wei Guo, Qi Zhu, Shihui Song, Yanni Xiang, Songjie Wu, Shi Zou, Yajun Yan, Ling Feng, Mingqi Luo, Ling Shen, Yong Feng, Ke Liang
Summary: This study investigated the function of peripheral cytokine-secreting cells in HIV/TB co-infection. The results showed that the absolute numbers of these cells were lower in patients with HIV/TB co-infection compared to TB or HIV infection alone. Additionally, the functional profiles of these cells were significantly different in HIV/TB co-infection. Furthermore, measuring the percentage of cytokine-secreting cells may be a sensitive marker for early evaluation of anti-TB treatment efficacy in HIV/TB co-infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Ning Gao, Yufeng Guo, Weiming Wang
Summary: This systematic review aims to assess the effectiveness and safety of acupuncture for patients with HIV-associated DSPN. Through searching various databases and selecting randomized controlled trials for study, the results will be disseminated via publication and conference presentation.
Article
Oncology
Aina Calls, Abel Torres-Espin, Xavier Navarro, Victor J. Yuste, Esther Udina, Jordi Bruna
Summary: The study used single-cell RNA sequencing to investigate the transcriptomic profile of sensory neurons in a CIPN mouse model, revealing that cisplatin treatment upregulates biological pathways related to DNA damage response in DRG neurons. Following cisplatin-induced DNA damage, DRG neurons exhibited senescence hallmarks without activation of apoptosis pathways.
Review
Environmental Sciences
Ines Klein, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of chemotherapy, affecting up to 60% of cancer patients. Paclitaxel induces neuropathy in gynecological and urological cancer patients, leading to cell death and affecting both central and peripheral nervous system cells. Symptoms include pain and numbness in hands and feet, with pathomechanisms involving axonal damage and disrupted axonal transport.
Article
Biology
Sattam Khulaif Alenezi
Summary: Thymoquinone (TQ), an active constituent of Nigella sativa, was found to significantly attenuate vincristine-induced neuropathy. TQ showed dose-dependent antinociceptive, antioxidant, and anti-inflammatory activity, as evidenced by increased reaction time on hot and cold plates, prolonged fall off time on a rotarod test, reduced flinches and duration of paw elevation in a formalin test, and decreased levels of malondialdehyde and glutathione depletion in the sciatic nerve tissue and IL-6 in the blood. These findings suggest that TQ may have potential therapeutic effects against neuropathic pain.
Article
Endocrinology & Metabolism
Narelle E. McGregor, Emma C. Walker, Audrey S. M. Chan, Ingrid J. Poulton, Ellie H-J Cho, Sara H. Windahl, Natalie A. Sims
Summary: Mice with targeted SOCS3 deletion exhibit an exaggerated response to mechanical loads, both physiological and experimental, highlighting the importance of osteocytic response in cortical bone maturation and the potential for enhanced bone formation by increasing STAT3 signaling within osteocytes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Ketlyn P. da Motta, Carolina C. Martins, Vanessa M. Macedo, Beatriz F. dos Santos, Nelson Luis De C. Domingues, Cristiane Luchese, Ethel A. Wilhelm
Summary: The study examined the effectiveness of MTDZ in alleviating PTX-induced peripheral neuropathy and its impact on various pathways. The results showed that MTDZ reduced mechanical and thermal sensitivities induced by PTX and modulated multiple pain-related pathways. Additionally, MTDZ reduced NOx levels and modulated Ca2+-ATPase activity.
Review
Health Care Sciences & Services
Roser Velasco, Montserrat Alemany, Macarena Villagran, Andreas A. Argyriou
Summary: Oxaliplatin is a platinum compound used in gastrointestinal cancer treatment, but its major toxicity is peripheral neurotoxicity. There is currently no effective strategy to reverse or treat this neurotoxicity, so early prediction of whether patients will develop neurotoxicity is crucial. Several biomarkers for predicting neurotoxicity have been described in recent years, which may assist clinicians in making better treatment decisions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Sebastian W. Nielsen, Simone Dyring Hasselsteen, Helena Sylow Heilmann Dominiak, Dejan Labudovic, Lars Reiter, Susanne Oksbjerg Dalton, Jorn Herrstedt
Summary: This study aimed to assess the safety, dosing, and preventive effects of cannabidiol (CBD) on chemotherapy-induced peripheral neuropathy (CIPN). The results showed that CBD attenuated early symptoms of CIPN with no major safety concerns. Further confirmation is needed in larger randomized studies.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Allison Jordan, Arun Nagaraj, J. Chad Hoyle, Amro Maher Stino, W. David Arnold, Bakri Elsheikh
Summary: This study investigated the association between peripheral neuropathy and CK elevation, finding that 20.4% of patients with peripheral neuropathy had hyperCKemia. Among them, 13.5% had a concomitant etiology explaining the CK elevation, while 6.9% had no other identifiable cause beyond the neuropathy. The frequency of cramping was higher in patients with elevated CK levels.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Scarlett Acklin, Fen Xia
Summary: Platinum-based chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating complication in cancer treatment, with dorsal root ganglia sensory neurons playing a key role in symptom development. Nucleotide excision repair is crucial for repairing platinum adducts and may serve as potential targets for future therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Allison D. Desforges, Chance M. Hebert, Allyson L. Spence, Bailey Reid, Hemangini A. Dhaibar, Diana Cruz-Topete, Elyse M. Cornett, Alan David Kaye, Ivan Urits, Omar Viswanath
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a complex condition that affects sensory functions. Currently, there are no approved preventive agents, but Duloxetine is an effective treatment. Developing prevention and treatment strategies for CIPN is crucial in improving patients' quality of life.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Jie Chen, Haili Shan, Wenjun Yang, Jiali Zhang, Haibin Dai, Ziqi Ye
Summary: The meta-analysis suggests that vitamin E has a beneficial effect on the incidence and symptoms of CIPN. However, results from double-blind studies indicated that vitamin E's efficacy in preventing CIPN is not significant. Routine prophylactic use of vitamin E is not recommended, and further high-quality studies are needed to validate its effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Manaal Siddiqui, Basma Abdellatif, Kevin Zhai, Alena Liskova, Peter Kubatka, Dietrich Busselberg
Summary: Flavonoids show promising potential in treating CIPN by reducing oxidative stress, inflammation, and neuronal damage. Further research is needed to evaluate the efficacy and side effects of flavonoids in human models before clinical benefits can be realized.