Review
Pharmacology & Pharmacy
Daniela Placha, Josef Jampilek
Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.
Article
Environmental Sciences
Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang
Summary: The overuse of antimicrobial agents is a key factor in the emergence of antibiotic resistance bacteria (ARB), but it is unclear whether non-antibiotic chemicals like nonsteroidal anti-inflammatory drug (NSAID) can induce ARB. This study investigated whether NSAID diclofenac (DCF) promotes the emergence of antibiotic resistance in Escherichia coli K12 MG1655. The results showed that DCF induced hereditary stable ARB and caused gene variation on the chromosome. DCF also triggered bacterial oxidative stress and SOS response, leading to enhanced expression of antioxidant and SOS system-related genes. However, high-dosage DCF reduced mutation frequency but enhanced mutant resistance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Allergy
Lily Li, Jillian Bensko, Kathleen Buchheit, Rebecca R. Saff, Tanya M. Laidlaw
Summary: This study investigated the safety and outcomes of two-step outpatient NSAID challenges for patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity. The results showed that more than 85% of the challenges were negative, allowing patients to use clinically indicated NSAIDs. The challenge reactions were generally mild.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Hong Ki Min, Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee
Summary: Targeting specific pathologic pro-inflammatory cytokines or related molecules with biologic disease-modifying anti-rheumatic drugs (bDMARDs), such as monoclonal antibodies, has shown excellent therapeutic effects in various forms of inflammatory arthritis. These bDMARDs can target different pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-17A, IL-6, and IL-23/12, and control the inflammatory response by targeting specific cell-surface molecules. The therapeutic efficacy and adverse events of bDMARDs vary among different types of inflammatory arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Els Mehuys, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, Koen Boussery
Summary: The concomitant use of NSAIDs and antithrombotic agents increases the risk of bleeding and thromboembolism. In this intervention study, community pharmacists screened for and managed interactions between these drugs. The results showed that most interactions did not result in a change of pharmacotherapy, but in some cases, changes in medication were made.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Hutka, Anett Varallyay, Szilvia B. Laszlo, Andras S. Toth, Balint Scheich, Sandor Paku, Imre Voros, Zoltan Pos, Zoltan V. Varga, Derek D. Norman, Andrea Balogh, Zoltan Benyo, Gabor Tigyi, Klara Gyires, Zoltan S. Zadori
Summary: Lysophosphatidic acid (LPA) plays an important role in both NSAID-induced gastric injury and small intestinal injury. The signaling pathway of LPAR2 receptor is involved in the development of small intestinal injury, as well as the inflammatory responses associated with ulceration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Applied
Prince Allawadhi, Vishakha Singh, Kannan Govindaraj, Isha Khurana, Lopmudra P. Sarode, Umashanker Navik, Anil Kumar Banothu, Ralf Weiskirchen, Kala Kumar Bharani, Amit Khurana
Summary: Polysaccharides are important biological polymers with diverse applications. Polysaccharide nanoparticles exhibit excellent drug delivery properties and therapeutic effects, making them promising for applications in diabetes, organ fibrosis, and arthritis.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, General & Internal
Mee Yeon Lee, Suhyun Lee, Kyu-Nam Heo, Woo-Youn Kim, Sun Hoi Jung, Young-Mi Ah, Ju-Yeun Lee
Summary: This study suggests that rebamipide can be considered as an alternative to PPI in elderly chronic tNSAID users without risk factors. However, elderly patients with other risk factors should use PPI rather than rebamipide.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Phung N Thai, Lu Ren, Wilson Xu, James Overton, Valeriy Timofeyev, Carol E. Nader, Michael Haddad, Jun Yang, Aldrin Gomes, Bruce D. Hammock, Nipavan Chiamvimonvat, Padmini Sirish
Summary: Chronic exposure to DIC increases oxidative stress and impairs cardiovascular function, resulting in severe cardiotoxicity.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Materials Science, Biomaterials
Heng Zhao, Saad Sene, Angelika M. Mielcarek, Sylvain Miraux, Nicolas Menguy, Dris Ihiawakrim, Ovidiu Ersen, Christine Pechoux, Nathalie Guillou, Joseph Scola, Jean-Marc Greneche, Farid Nouar, Simona Mura, Florent Carn, Florence Gazeau, Eddy Dumas, Christian Serre, Nathalie Steunou
Summary: In this study, a hierarchically porous nano-object (USPIO@MIL) was designed through a one-pot, cost-effective and environmentally friendly protocol, combining a benchmark nanoMOF (MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (maghemite). The USPIO@MIL nano-object exhibited valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity, stimuli-responsive drug release, and superparamagnetic properties. It also showed high anti-inflammatory and anti-tumoral activities when loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate), and demonstrated excellent relaxometric properties as an efficient contrast agent for magnetic resonance imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Yusuke Karasawa, Isao Kamae, Kazutaka Nozawa, Shigeki Zeniya, Tatsunori Murata, Satoshi Soen, Choitsu Sakamoto
Summary: This study aimed to compare the cost-effectiveness of branded and authorized generic celecoxib in chronic pain patients with osteoarthritis, rheumatoid arthritis, and low back pain, with real-world cost data for loxoprofen. The results showed that AG celecoxib offers good value for costs considering patients' future gastrointestinal injury risk, and the impact on costs compared to loxoprofen is minimal. The incremental cost-effectiveness ratio for branded celecoxib was higher than that of loxoprofen, indicating possible benefits in terms of cost-effectiveness during prognosis.
Review
Rheumatology
Ho So, Lai-Shan Tam
Summary: Recent research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) may have a neutral or decreased cardiovascular risk in patients with spondyloarthritis (SpA), providing some reassurance for their use. However, the use of these drugs still varies in different regions.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Neurosciences
Laura Minnema, Ankita Gupta, Santosh K. Mishra, B. Duncan X. Lascelles
Summary: This study investigates the functional role of artemin/GFR alpha 3 signaling in osteoarthritis pain and finds that anti-artemin monoclonal antibody can reverse hypersensitivity and restore limb use.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Veterinary Sciences
A. Wright, D. M. Amodie, N. Cernicchiaro, B. D. X. Lascelles, A. M. Pavlock, C. Roberts, D. J. Bartram
Summary: The objective of this study was to investigate the diagnostic value of an owner-completed canine osteoarthritis screening checklist and assess the response to carprofen treatment in previously undiagnosed cases. The results showed that more osteoarthritis cases were identified than previous estimates, indicating the potential of the screening checklist. Furthermore, functional improvements were observed after carprofen treatment.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Veterinary Sciences
Margaret E. Gruen, B. Duncan X. Lascelles, Elizabeth Colleran, Alison Gottlieb, Jennifer Johnson, Peter Lotsikas, Denis Marcellin-Little, Bonnie Wright
Summary: These updated guidelines provide a practical approach to assessing and managing acute and chronic pain in dogs and cats, including diagnostic guides, algorithms, and pain-assessment instruments for pet owners. Proactive pain management and a variety of treatment options are emphasized.
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Tiffany A. Johnson, Wanda J. Gordon-Evans, B. Duncan X. Lascelles, Michael G. Conzemius
Summary: The center of mass (CoM) plays a crucial role in balance and motion in dogs, but its relationship with subject morphometrics is poorly understood. This study aimed to estimate the variance of CoM in a heterogeneous population of dogs and describe its relationship with subject morphometrics. It was found that dog length was the primary variable affecting the three-dimensional CoM, and a CoM-based normalization procedure should be considered to minimize outcome measure variations in dogs with different body types.
Article
Veterinary Sciences
B. P. Monteiro, B. D. X. Lascelles, J. Murrell, S. Robertson, P. V. M. Steagall, B. Wright
Summary: The 2022 WSAVA Global Pain Management Guidelines provide core fundamentals for recognizing and treating pain in small animal clinical practice. It is a valuable resource for veterinary health professionals to mitigate animal suffering and promote animal welfare.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Molly A. Vitt, Aaron Rendahl, Sara E. Pracht, Brooke M. Knotek, B. Duncan X. Lascelles, Wanda Gordon-Evans, Michael G. Conzemius
Summary: This study aimed to investigate the relationships between the output of a 9-axis inertial measurement unit (IMU) and activities of varying intensity in dogs of various sizes. The results showed that the IMU output clearly discriminates between activities of different intensities in dogs. These findings demonstrate the concurrent and predictive validity of the tested IMU for assessing activity in a dog's natural environment.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
John F. Innes, Mark A. Morton, B. Duncan X. Lascelles
Summary: The 'Liverpool Osteoarthritis in Dogs' (LOAD) and the 'Canine Orthopedic Index' (COI) have been validated for evaluating canine osteoarthritis, but the minimal clinically-important differences (MCIDs) for these measures have not been investigated. This study provided estimates for the MCIDs of LOAD and COI, which will aid in sample size estimates for future clinical trials using these measures.
Article
Veterinary Sciences
Naruepon Kampa, Duangdaun Kaenkangploo, Supranee Jitpean, Thanikul Srithunyarat, Suvaluk Seesupa, Somphong Hoisang, Karn Yongvanit, Phanthit Kamlangchai, Pongsatorn Tuchpramuk, B. Duncan X. Lascelles
Summary: This study evaluated the efficacy of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the alleviation of canine hip osteoarthritis pain, and found that PCSO-524 and EAB-277 significantly improved the symptoms of canine hip osteoarthritis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Alejandra Mondino, Michael Khan, Beth Case, Sara Giovagnoli, Andrea Thomson, B. Duncan X. Lascelles, Margaret Gruen, Natasha Olby
Summary: Maintaining an active lifestyle is crucial for successful aging, as physical activity reduces the risk of cognitive decline and Alzheimer's disease. However, pain and lack of motivation can hinder exercise. Dogs, being prone to Canine Cognitive Dysfunction syndrome, are a valuable model for aging and cognition studies. This research found associations between dogs' activity patterns, lifespan, and cognitive status, highlighting the potential benefits of physical activity in delaying cognitive impairment in senior dogs.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Constanza S. Meneses, Emily M. Gidcumb, Karen L. Marcus, Yarines Gonzalez, Yen Hao Lai, Santosh K. Mishra, B. Duncan X. Lascelles, Michael W. Nolan
Summary: This study tested the hypothesis that severe acute radiotherapy-induced pain can accelerate tumor growth at distant sites. The results showed that tongue irradiation promoted lung tumor growth. This suggests that activation of capsaicin-responsive neurons may be the cause of accelerated tumor growth at distant sites.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
A. Mondino, C. Ludwig, C. Menchaca, K. Russell, K. E. Simon, E. Griffith, A. Kis, B. D. X. Lascelles, M. E. Gruen, N. J. Olby
Summary: This study demonstrates that the SNoRE 3.0 questionnaire is a valid and reliable tool for monitoring dog sleep, providing a cost-effective alternative to labor-intensive and expensive methods. Additionally, a moderate positive correlation was found between SNoRE scores and cognitive performance in companion dogs.
SCIENTIFIC REPORTS
(2023)
Correction
Veterinary Sciences
Naruepon Kampa, Duangdaun Kaenkangploo, Supranee Jitpean, Thanikul Srithunyarat, Suvaluk Seesupa, Somphong Hoisang, Karn Yongvanit, Phanthit Kamlangchai, Pongsatorn Tuchpramuk, B. Duncan X. Lascelles
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Veterinary Sciences
Thibaut Cachon, Ole Frykman, John F. Innes, B. Duncan X. Lascelles, Masahiro Okumura, Pedro Sousa, Francesco Staffieri, Paulo V. Steagall, Bernadette Van Ryssen
Summary: This report provides consensus guidelines and recommendations for the treatment of canine osteoarthritis (OA) based on the Canine OsteoArthritis Staging Tool excluding radiography (COASTeR) stage. The aim is to provide veterinarians with practical reference and support the development of patient-specific OA management protocols and informed treatment choices.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Clinical Neurology
Rachel M. P. Caddiell, Rachael M. M. Cunningham, Philip A. A. White, B. Duncan X. Lascelles, Margaret E. E. Gruen
Summary: This study evaluated whether pain sensitivity thresholds differ across a set of dog breeds and whether veterinarians' pain sensitivity ratings can explain these differences or if they are attributed to behavioral characteristics. The results showed that there were differences in pain sensitivity thresholds across different dog breeds, but veterinarians' ratings had minimal explanatory power for these differences.
FRONTIERS IN PAIN RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yu-Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese
Summary: This study demonstrates the feasibility of using adenosine and its material-assisted local delivery as a therapeutic approach to treat bone trauma and associated pain. Adenosine provides pain relief and promotes bone healing simultaneously, offering an improved method compared to current therapeutics.