Article
Medicine, Research & Experimental
Rida Nisar, Zehra Batool, Saida Haider
Summary: This study aims to improve the practice of using electric foot-shock to generate anxiety-like symptoms by identifying an optimum current intensity and combining it with behavioral paradigms. The results showed that 1.0 mA electric foot-shock induced abnormal behavioral effects similar to anxiety-like effects. Furthermore, aberrations in various physiological parameters were observed in the rat model of anxiety, which were successfully alleviated by diazepam.
Article
Biochemistry & Molecular Biology
Joel Castro, Jessica Maddern, Luke Grundy, Jim Manavis, Andrea M. Harrington, Gudrun Schober, Stuart M. Brierley
Summary: This study utilized an autologous mouse model of endometriosis to examine disease features and symptoms including lesion development, chronic inflammatory environment, neuroangiogenesis, sensory hypersensitivity, and altered pain responses. The study found significant increases in lesion size, endometrial glands, stroma, and neuroangiogenesis. Mice with endometriosis displayed enhanced pain sensitivity and altered bladder function compared to control mice.
Article
Veterinary Sciences
William R. Nugent, Linda Daugherty
Summary: About 38.4% of U.S. households have dogs and 25.4% have cats as pets. A recent poll showed that over 90% of pet owners consider their pets as family members. While numerous studies suggest the health benefits of pet ownership, there have been mixed results. A review revealed measurement problems in human-animal interaction and human-animal bond research, such as lack of validity evidence, lengthy measures, and absence of measurement equivalence across different pet species. This article presents a new measure called the family bondedness scale (FBS) and its measurement equivalence study, which addresses these gaps in human-animal bond measurement.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Tadashi Tanioku, Masayuki Nishibata, Yasuyuki Tokinaga, Kohtaro Konno, Masahiko Watanabe, Hiroaki Hemmi, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Hidemasa Furue, Tomoyuki Kawamata
Summary: This study demonstrates the essential role of Tmem45b in inflammation- and tissue injury-induced mechanical pain hypersensitivity, highlighting it as a potential therapeutic target for future treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Sabrina L. McIlwrath, Marlene E. Starr, Abigail E. High, Hiroshi Saito, Karin N. Westlund
Summary: The study aimed to investigate the effects of acetyl-L-carnitine on pain behaviors and brain microglial activation in a mouse model of CAE-induced pancreatitis. The results showed that ALC can alleviate mechanical and heat hypersensitivity induced by pancreatitis, but not hypersensitivity caused by abdominal wall injury from repeated injections.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Clinical Neurology
Dimitri Daldegan-Bueno, Natalia Maria Simionato, Vanessa Manchim Favaro, Lucas Oliveira Maia
Summary: This article reviews and summarizes the available data on ayahuasca research using animal models. The results show that ayahuasca has toxicological effects at high doses but is safe at ceremonial-based doses. It exhibits antidepressant effects and has the potential to reduce the reward effects of ethanol and amphetamines. However, its anxiolytic effects are inconclusive. Ayahuasca also affects brain structures involved in memory, emotion, and learning. Animal models are essential for further studying the therapeutic potential of ayahuasca.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz, Edda Tschernko
Summary: This study developed a method of creating a unilateral acute lung injury model in pigs and evaluated the key parameters. The experiment confirmed the successful induction of unilateral lung injury in pigs using this model, reducing the number of animals required for experiments while obtaining valid conclusions. The results of the study suggest that this model has good clinical application value.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Carolina Macedo-Souza, Silvia Soares Maisonnette, Jaime E. Hallak, Jose A. Crippa, Antonio W. Zuardi, J. Landeira-Fernandez, Christie Ramos Andrade Leite-Panissi
Summary: Studies have shown that anxiety disorder and chronic pain, including generalized anxiety disorder (GAD) and neuropathic pain, often coexist. Cannabidiol (CBD) has shown promise as a treatment for these conditions. This study investigated the effects of chronic CBD treatment on pain in rats with high- and low-freezing anxiety levels (GAD model) and control rats with chronic neuropathic pain. The results showed that CBD had an anti-allodynic effect on mechanical and thermal pain thresholds in all rat groups, but the effect was weaker in rats with high- and low-freezing anxiety. CBD treatment also demonstrated an anxiolytic effect in control and high-freezing anxiety rats with chronic neuropathic pain and increased mobility in low-freezing anxiety rats without nerve injury. These findings suggest that the mechanical and emotional effects of CBD may be influenced by anxiety levels.
Article
Immunology
Chen Wang, Lulu Wu, Runjin Zhou, Cuiwen Song, Peng Chen, Shiying Huang, Ahsan Ali Khan, Deng Lu, Yong Hu, Lukui Chen
Summary: This study found that emodin has a role in relieving neuropathic pain, possibly by inhibiting inflammation, increasing the proportion of beneficial bacteria, and beneficial metabolites.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Yuheng Liu, Xuanhui Liu, Zhijuan Chen, Yuanzhi Wang, Jing Li, Junjie Gong, Anqi He, Mingyu Zhao, Chen Yang, Weidong Yang, Zengguang Wang
Summary: Decompressive craniectomy (DC) is crucial for decreasing intracranial pressure and improving neurological function after traumatic brain injury (TBI). This study investigated the effects of DC on a severe TBI mouse model and found that DC can reduce intracranial pressure, improve neurological and motor function, and attenuate blood-brain barrier damage, inflammatory response, and neuronal apoptosis. However, DC may also lead to brain edema and long-term impairment of neurological function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Maja Kesic, Gordana Mokrovic, Ante Tvrdeic, Branko Mise, Jasminka Stefulj, Lipa Cicin-Sain
Summary: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications for treating mood disorders, but individual response to SSRIs varies. Individual serotonin levels may play a role in influencing the biological actions of SSRIs.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Phillip R. Zoladz, Colin R. Del Valle, Ian F. Smith, Cassandra S. Goodman, Jordan L. Dodson, Kara M. Elmouhawesse, Charis D. Kasler, Boyd R. Rorabaugh
Summary: This study exposed female rats to a predator-based psychosocial stress model of PTSD, and found that stressed females exhibited significantly lower corticosterone levels and greater corticosterone suppression, despite not showing heightened anxiety in behavioral tests. These findings suggest that this model could be useful for studying HPA axis function changes in females exposed to trauma.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Stacey Anne Gould, Matthew White, Anna L. Wilbrey, Erzsebet Por, Michael Philip Coleman, Robert Adalbert
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment associated with sensory axon degeneration. While WLDS and SARM1 have been shown to protect against axon degeneration, SARM1 deletion can alleviate acute oxaliplatin-induced pain, suggesting an independent mechanism of pain hypersensitivity in early stages. Targeting SARM1 may be a potential therapeutic approach for preventing oxaliplatin-induced acute neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Anesthesiology
Diana Amorim, Diana Fonseca-Rodrigues, Ana David-Pereira, Octavia Costa, Antonia Palhares Lima, Rosete Nogueira, Rute Cruz, Ana Sofia Martins, Liliana Sousa, Francisco Oliveira, Helder Pereira, Rogerio Pirraco, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
Summary: The injection of kaolin/carrageenan in the rat knee joint successfully models the physical and psychiatric features of human osteoarthritis. This experimental osteoarthritis allows for the study of disease mechanisms and evaluation of therapeutic strategies to halt disease progression at different stages.
Article
Endocrinology & Metabolism
Amanda M. Rooney, Tyler J. McNeill, F. Patrick Ross, Mathias P. G. Bostrom, Marjolein C. H. van der Meulen
Summary: Parathyroid hormone (PTH) is an effective treatment for increasing bone mass and reducing fracture risk in osteoporosis. Its effects vary depending on the site, with greater bone mass increase at the spine than the hip and no increase at the radius. The differences in local loading mode may contribute to these variations. This study found that compression loading is more anabolic than tension loading, and PTH enhances the effect of loading, particularly under compression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Anesthesiology
Jennifer S. Gewandter, Robert H. Dworkin, Dennis C. Turk, Michael P. McDermott, Ralf Baron, Marc R. Gastonguay, Ian Gilron, Nathaniel P. Katz, Cyrus Mehta, Srinivasa N. Raja, Stephen Senn, Charles Taylor, Penney Cowan, Paul Desjardins, Rozalina Dimitrova, Raymond Dionne, John T. Farrar, David J. Hewitt, Smriti Iyengar, Gary W. Jay, Eija Kalso, Robert D. Kerns, Richard Leff, Michael Leong, Karin L. Petersen, Bernard M. Ravina, Christine Rauschkolb, Andrew S. C. Rice, Michael C. Rowbotham, Cristina Sampaio, Soren H. Sindrup, Joseph W. Stauffer, Ilona Steigerwald, Jonathan Stewart, Jeffrey Tobias, Rolf-Detlef Treede, Mark Wallace, Richard E. White
Article
Behavioral Sciences
Ombretta Caspani, Marie-Celine Reitz, Angelo Ceci, Andreas Kremer, Rolf-Detlef Treede
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2014)
Editorial Material
Anesthesiology
J. Tesarz, A. Gerhardt, R. -D. Treede, W. Eich
Article
Anesthesiology
A. Schilder, U. Hoheisel, W. Magerl, J. Benrath, T. Klein, R. -D. Treede
Article
Anesthesiology
A. Kopf, M. Dusch, B. Alt-Epping, F. Petzke, R-D. Treede
Article
Clinical Neurology
Edda Bilek, Zhenxiang Zang, Isabella Wolf, Florian Henrich, Carolin Moessnang, Urs Braun, Rolf-Detlef Treede, Walter Magerl, Andreas Meyer-Lindenberg, Heike Tost
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Clinical Neurology
Daniela C. Rosenberger, Vivian Blechschmidt, Hans Timmerman, Andre Wolff, Rolf-Detlef Treede
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Medicine, Research & Experimental
Daniela C. Rosenberger, Uta Binzen, Rolf-Detlef Treede, Wolfgang Greffrath
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Neurosciences
Katharina Sessler, Vivian Blechschmidt, Ulrich Hoheisel, Siegfried Mense, Lucas Schirmer, Rolf-Detlef Treede
Summary: Fractalkine signaling plays a critical role in the sensitization of dorsal horn neurons induced by repetitive nociceptive stimuli, suggesting it may be a potential target for preventing nonspecific, myofascial low back pain. Blocking fractalkine signaling with neutralizing antibodies prevents spinal sensitization, while intrathecal administration of fractalkine induces similar sensitization patterns as nociceptive stimuli.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biology
Walter Magerl, Emanuela Thalacker, Simon Vogel, Robert Schleip, Thomas Klein, Rolf-Detlef Treede, Andreas Schilder
Summary: The study investigated the somatosensory changes in the skin after stimulation of underlying fascia, with findings suggesting significant hyperalgesia in the skin resulting from the stimulation. The experiments demonstrated the potential for across-tissue facilitation to pinprick stimulation, indicating nociceptive central sensitization.
Article
Anesthesiology
Beatrice Korwisi, Antonia Barke, Winfried Rief, Rolf-Detlef Treede, Maria Kleinstaeuber
Summary: For the first time, the upcoming ICD-11 will include a comprehensive classification of chronic pain, based on the biopsychosocial definition. This publication provides answers to frequently asked questions about the ICD-11 chronic pain classification, aiming to guide future users and facilitate its implementation.
Review
Anesthesiology
Michiel F. Reneman, Melissa Selb, Beatrice Korwisi, Antonia Barke, Reuben S. Escorpizo, Samson W. Tu, Rolf-Detlef Treede
Summary: This article provides supplemental digital content.
Article
Anesthesiology
Katharina Fiona Zehetmeier, Melissa Kathrin Froehlich, Andreas Schilder, Stefanie Lis, Christian Schmahl, Rolf-Detlef Treede, Marc Suetterlin
Summary: This study aimed to investigate the impact of adverse childhood experiences (ACEs) on pain experiences in pregnant women. The findings showed that pregnant women with ACEs had higher sensitivity and severity of back pain, as well as a higher prevalence of preexisting back pain. Special care should be provided for these women.
Article
Clinical Neurology
Armin Drusko, Malika Renz, Hannah Schmidt, Lea Schloemp, Vassilios Papaiannou, Norbert Schmidt, Heike Tost, Rolf-Detlef Treede, Wolfgang Eich, Jonas Tesarz
Summary: The majority of knowledge about fibromyalgia syndrome (FMS) comes from studies of female patients. Little is known about the clinical characteristics and treatment outcomes of male patients with FMS. This study compared male and female FMS patients in terms of symptom burden, psychological characteristics, and clinical treatment response. The findings suggest that male FMS patients have specific differences in interpersonal problems and pain coping mechanisms, which should be considered in their treatment.
Review
Anesthesiology
Rolf-Detlef Treede, Ulrich Hoheisel, Dan Wang, Walter Magerl
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
