Zebrafish as model organisms for studying drug-induced liver injury

Development of a Convenient In Vivo Hepatotoxin Assay Using a Transgenic Zebrafish Line with Liver-Specific DsRed Expression

(2014) Xiaoyan Zhang et al.   PLoS One

Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity

(2014) Adriaan D.B. Vliegenthart et al.   Zebrafish

S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury

(2014) Andrew G. Cox et al.   Cell Reports

The emerging use of zebrafish to model metabolic disease

(2013) A. Seth et al.   Disease Models & Mechanisms

PXR antagonists and implication in drug metabolism

(2013) Sridhar Mani et al.   DRUG METABOLISM REVIEWS

Evolution and function of chemokine receptors in the immune system of lower vertebrates

(2013) Baubak Bajoghli   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish

(2013) Fatemeh Babaei et al.   JOURNAL OF PROTEOME RESEARCH

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

(2013) Feng Li et al.   NATURE MEDICINE

A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish

(2013) Liqing Zang et al.   Zebrafish

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(2012) Barry H Rumack et al.   CLINICAL TOXICOLOGY

Role of immune reactions in drug-induced liver injury (DILI)

(2012) Cynthia Ju et al.   DRUG METABOLISM REVIEWS

Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

(2012) Adrian Hill et al.   DRUG METABOLISM REVIEWS

Pharmacokinetics of Intravenous Ibuprofen

(2012) Howard S. Smith et al.   DRUGS

Natural killer cells in liver disease

(2012) Zhigang Tian et al.   HEPATOLOGY

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolism of ibuprofen in zebrafish larvae

(2012) Huw S. Jones et al.   XENOBIOTICA

A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity

(2012) Jian-Hui He et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

(2011) Kathleen Van den Bulck et al.   REPRODUCTIVE TOXICOLOGY

Normal Anatomy and Histology of the Adult Zebrafish

(2011) Aswin L. Menke et al.   TOXICOLOGIC PATHOLOGY

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

(2010) T. E. North et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

(2010) W. Alderton et al.   XENOBIOTICA

Blood Sugar Measurement in Zebrafish Reveals Dynamics of Glucose Homeostasis

(2010) Stefani C. Eames et al.   Zebrafish

Liver development in zebrafish (Danio rerio)

(2009) Ting Tao et al.   Journal of Genetics and Genomics

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Comparison between zebrafish and Hep G2 assays for the predictive identification of hepatotoxins

(2009) Mathew Jones et al.   TOXICOLOGY

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

(2009) J. E. Laine et al.   XENOBIOTICA

Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY

Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates

(2008) Caitlin M. Brown et al.   DRUG METABOLISM REVIEWS

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

(2008) Michael J. Passeri et al.   HEPATOLOGY

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

(2008) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS