PXR antagonists and implication in drug metabolism

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

(2012) Satyanarayana R. Pondugula et al.   CANCER LETTERS

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

(2012) Cheng-Ling Liu et al.   Marine Drugs

Chronic Exposure to Rifaximin Causes Hepatic Steatosis in Pregnane X Receptor-Humanized Mice

(2012) Jie Cheng et al.   TOXICOLOGICAL SCIENCES

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

(2012) Jie Cheng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interaction between Artemether-Lumefantrine and Nevirapine-Based Antiretroviral Therapy in HIV-1-Infected Patients

(2011) T. Kredo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

(2011) Arunima Biswas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

(2011) Lucie Krausova et al.   BIOCHEMICAL PHARMACOLOGY

HIV and TB coinfection: using adjusted doses of lopinavir/ritonavir with rifampin

(2011) Adrian Curran et al.   Expert Review of Anti-Infective Therapy

PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

(2011) Jinhan He et al.   GASTROENTEROLOGY

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of novel pregnane X receptor activators from traditional Chinese medicines

(2011) Chunna Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Deficiency of PXR decreases atherosclerosis in apoE-deficient mice

(2011) Yipeng Sui et al.   JOURNAL OF LIPID RESEARCH

FXR and PXR: Potential therapeutic targets in cholestasis

(2011) Johan W. Jonker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

(2011) Víctor Buzón et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation

(2011) M. Venkatesh et al.   MOLECULAR PHARMACOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Post-translational modification of pregnane x receptor

(2011) Jeff L. Staudinger et al.   PHARMACOLOGICAL RESEARCH

Drug–drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition

(2011) Zdenek Dvorak   TOXICOLOGY LETTERS

Overcoming drug resistance by regulating nuclear receptors

(2010) Taosheng Chen   ADVANCED DRUG DELIVERY REVIEWS

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

(2010) Marta Moya et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pharmacokinetic Interactions between Etravirine and Non-Antiretroviral Drugs

(2010) Thomas N. Kakuda et al.   CLINICAL PHARMACOKINETICS

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

(2010) Bin Zhang et al.   ENDOCRINOLOGY

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells

(2010) Aneta Novotna et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pregnane X Receptor Is SUMOylated to Repress the Inflammatory Response

(2010) G. Hu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor

(2010) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human Pregnane X Receptor Agonism by Ginkgo biloba Extract: Assessment of the Role of Individual Ginkgolides

(2010) A. J. Lau et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

(2010) J. Cheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

(2010) Caroline Raynal et al.   Molecular Cancer

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays

(2010) Hiroyuki Kojima et al.   TOXICOLOGY

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

(2009) Francesca Borrelli et al.   AAPS Journal

Update on Rifampin and Rifabutin Drug Interactions

(2009) Anne M. Baciewicz et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Pharmakokinetische Probleme in der Praxis

(2009) D Rosskopf et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

(2009) J. Cheng et al.   DRUG METABOLISM AND DISPOSITION

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice

(2009) Changcheng Zhou et al.   JOURNAL OF LIPID RESEARCH

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Minireview: Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRAMs)

(2009) Terry W. Moore et al.   MOLECULAR ENDOCRINOLOGY

Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice

(2009) Menno Hoekstra et al.   MOLECULAR PHARMACEUTICS

Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

(2009) Arunima Biswas et al.   PHARMACEUTICAL RESEARCH

Pregnane X Receptor and its Potential Role in Drug Resistance in Cancer Treatment

(2009) Yakun Chen et al.   Recent Patents on Anti-Cancer Drug Discovery

PXR agonism decreases plasma HDL levels in ApoE⁎3-Leiden.CETP mice

(2008) Willeke de Haan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR)

(2008) Bhaskar C. Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer

(2008) D. Gupta et al.   CLINICAL CANCER RESEARCH

Clinical??Relevance??of??Pharmacokinetics and??Pharmacodynamics??in Cardiac??Critical??Care??Patients

(2008) Federico Pea et al.   CLINICAL PHARMACOKINETICS

Novel Orphan Nuclear Receptors-Coregulator Interactions Controlling Anti-Cancer Drug Metabolism

(2008) Radharani Gollamudi et al.   CURRENT DRUG METABOLISM

Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists

(2008) S. Ekins et al.   MOLECULAR PHARMACOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY