Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

(2011) Kathleen Van den Bulck et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

(2011) Stefan Weigt et al.   TOXICOLOGY

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

(2010) Nigel Greene et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury

(2010) S. Ekins et al.   DRUG METABOLISM AND DISPOSITION

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation

(2010) Benjamin D. Cosgrove et al.   Molecular BioSystems

Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

(2010) D. P. Jones et al.   MOLECULAR INTERVENTIONS

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

(2010) David C. Hay et al.   Stem Cell Research

A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures

(2010) Yeonhee Kim et al.   TISSUE ENGINEERING PART C-METHODS

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies

(2010) David E. Amacher   TOXICOLOGY

Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies☆

(2010) John W. Benbow et al.   TOXICOLOGY LETTERS

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

(2010) W. Alderton et al.   XENOBIOTICA

Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo

(2010) Huw S. Jones et al.   Zebrafish

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

(2009) Jonathon N. Bauman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

The use ofin vivozebrafish assays in drug toxicity screening

(2009) Peter M Eimon et al.   Expert Opinion on Drug Metabolism & Toxicology

Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes

(2009) Na Li et al.   MOLECULAR PHARMACEUTICS

Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

(2009) Bo Feng et al.   TOXICOLOGICAL SCIENCES

Comparison between zebrafish and Hep G2 assays for the predictive identification of hepatotoxins

(2009) Mathew Jones et al.   TOXICOLOGY

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

(2009) Benjamin D. Cosgrove et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury

(2008) Yie Hou Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zebrafish Whole-Adult-Organism Chemogenomics for Large-Scale Predictive and Discovery Chemical Biology

(2008) Siew Hong Lam et al.   PLoS Genetics