Article
Biochemistry & Molecular Biology
Asami Mori, Haruka Seki, Satoru Mizukoshi, Takashi Uezono, Kenji Sakamoto
Summary: This study finds that NO-induced neuronal cell action on glial cells causes vasodilation in the rat retina through the activation of prostanoid EP2 receptors via the arachidonic acid cascade. Glial cell-derived PGE(2) may play an important role in retinal vasodilatory mechanisms.
Review
Cell Biology
Weida Shen, Jelena Bogdanovic Pristov, Paola Nobili, Ljiljana Nikolic
Summary: Epilepsy is a neurological disorder with approximately 30% of patients being resistant to current medications. Recent research suggests that the role of glial cells in epilepsy should be considered, as their supportive roles and interaction with neurons are disrupted in epileptic brains. Dysfunction of glial cells, such as astroglial potassium channels, water channels, gap junctions, glutamate transporters, purinergic signaling, synaptogenesis, microglial inflammatory cytokines, microglia-astrocyte interactions, and oligodendroglial potassium channels, may contribute to abnormal neuronal activity and can be potential targets for new anti-epileptic drugs.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Schuichi Koizumi, Yuri Hirayama
Summary: Ischemic tolerance is the phenomenon of acquiring resistance to subsequent invasive ischemia through a preceding noninvasive ischemic application. In the context of cerebral ischemic tolerance, microglia and astrocytes play essential roles in inducing ischemic tolerance through neuron-non-autonomous mechanisms.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Reece Andrew Sophocleous, Lezanne Ooi, Ronald Sluyter
Summary: The article provides an overview of the current understanding of the P2X4 receptor and its role in neuroinflammatory signaling, discussing the pharmacology of P2X4 receptors and targeting molecules, as well as the use of P2X4 receptor modulators and antagonists in neuroinflammatory disease models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Songyeon Choi, Kyeongmin Kim, Minjee Kwon, Sun Joon Bai, Myeounghoon Cha, Bae Hwan Lee
Summary: Inhibition of neuroglia activity in the insular cortex can alleviate chronic pain, and purinergic receptors in glial cells are closely related to chronic pain development.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biology
Isabella Boccuni, Richard Fairless
Summary: Disturbances in glutamate homeostasis can result in glutamate excitotoxicity, leading to degeneration of retinal neurons. The NMDA receptor plays a major role in the neurodegenerative mechanisms induced by glutamate.
Review
Neurosciences
Peter Kovermann, Miriam Engels, Frank Mueller, Christoph Fahlke
Summary: Excitatory amino acid transporters (EAATs) play a crucial role in optimizing the temporal resolution and energy demand of excitatory synapses. In addition to their primary transport function, EAATs also function as anion channels. Recent research has shed light on the physiological and pathophysiological roles of EAAT anion channels.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Developmental Biology
Elisabeth Kugler, Isabel Bravo, Xhuljana Durmishi, Stefania Marcotti, Sara Beqiri, Alicia Carrington, Brian Stramer, Pierre Mattar, Ryan B. MacDonald
Summary: Cell morphology is important for cell functions, especially for glial cells that rely on complex shape for neuron support. However, accurate and reproducible methods to quantify complex glial cell shape are lacking. To address this, the image analysis pipeline 'GliaMorph' was developed, enabling in-depth understanding of glial cell morphology in the developing and diseased retina.
Article
Cell Biology
Meytal Cohen, Rachel Feldman-Goriachnik, Menachem Hanani
Summary: Research indicates that enhanced intercellular communications in sensory ganglia following nerve injury or inflammation may lead to abnormal neuronal activity, resulting in pain. Changes in both neurons and satellite glial cells (SGCs) in sensory ganglia may play a role in itch.
Article
Cell Biology
Zhiyong Chen, Chi Zhang, Xiaodan Song, Xiang Cui, Jing Liu, Neil C. Ford, Shaoqiu He, Guangwu Zhu, Xinzhong Dong, Menachem Hanani, Yun Guan
Summary: The purinergic system, specifically the P2X7R receptor, plays an important role in pain transmission and the interactions between neuron-satellite glial cells in the dorsal root ganglia (DRG). Activation of P2X7R leads to the release of ATP, which excites neurons and increases DRG neuron excitability. Understanding this signaling pathway could provide insights into pain mechanisms and potential targets for pain management.
Article
Pharmacology & Pharmacy
Kenneth A. Jacobson, Adriaan P. IJzerman, Christa E. Mueller
Summary: This review paper explores the historical origins of P2 receptors and adenosine receptor ligands, emphasizing the versatility of common chemical scaffolds for multiple receptor targets. By analyzing structure activity relationships, selective receptor subtype targeting can be achieved, leading to potential therapeutic applications in various diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Martinez-Gil, Oksana Kutsyr, Agustina Noailles, Laura Fernandez-Sanchez, Lorena Vidal, Xavier Sanchez-Saez, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca, Antonio G. Garcia, Victoria Maneu
Summary: P2X7R and P2X4R play important roles in retinal diseases and their expression increases during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Igor Santiago-Carvalho, Gislane Almeida-Santos, Bruna Gois Macedo, Caio Cesar Barbosa-Bomfim, Fabricio Moreira Almeida, Marcos Vinicios Pinheiro Cione, Trupti Vardam-Kaur, Mia Masuda, Sarah Van Dijk, Bruno Marcel Melo, Rogerio Silva do Nascimento, Rebeka da Conceicao Souza, Alba Lucinia Peixoto-Rangel, Robson Coutinho-Silva, Mario Hiroyuki Hirata, Jose Carlos Alves-Filho, Jose Maria Alvarez, Elena Lassounskaia, Henrique Borges da Silva, Maria Regina D'Imperio-Lima
Summary: CD4+ T cells play a crucial role in the immune response and protection against lung infections, but can also contribute to lung pathology. This study suggests that the accumulation of CD4+ T cells in the lung is mediated by the P2RX7 receptor, and their direct sensing of extracellular ATP is critical for tissue accumulation and pathology during lung infections.
Article
Immunology
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang
Summary: The study found that purinergic receptor P2RX1 is highly expressed in acute pancreatitis and plays a role in promoting neutrophil activation to contribute to the inflammatory response, making it a potential therapeutic target for treating the disorder inflammation in acute pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Claire Hippert, Anna B. Graca, Mark Basche, Aikaterini A. Kalargyrou, Anastasios Georgiadis, Joana Ribeiro, Ayako Matsuyama, Nozie Aghaizu, James W. Bainbridge, Alexander J. Smith, Robin R. Ali, Rachael A. Pearson
Summary: Gliosis is a complex process involving upregulation of IF proteins, changes in glial morphology, and increased deposition of inhibitory ECM molecules. Through RNAi approaches, it was found that GFAP and vimentin play crucial roles in the establishment of glial hypertrophy during disease progression. Suppression of both proteins led to severe changes in the retina's cytoarchitecture, suggesting potential therapeutic implications for modulating scar formation.
Article
Immunology
Kristin Mages, Felix Grassmann, Herbert Jaegle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck, Antje Grosche
JOURNAL OF NEUROINFLAMMATION
(2019)
Review
Ophthalmology
Farhad Ghaseminejad, Lew Kaplan, Anna M. Pfaller, Stefanie M. Hauck, Antje Grosche
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Cell Biology
Diana Pauly, Divyansh Agarwal, Nicholas Dana, Nicole Schaefer, Josef Biber, Kirsten A. Wunderlich, Yassin Jabri, Tobias Straub, Nancy R. Zhang, Avneesh K. Gautam, Bernhard H. F. Weber, Stefanie M. Hauck, Mijin Kim, Christine A. Curcio, Dwight Stambolian, Mingyao Li, Antje Grosche
Article
Immunology
Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Valerie Forster, Nour Barmo, Sebastien Augustin, Serge Picaud, Jose-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Florian Sennlaub, Xavier Guillonneau
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Biochemistry & Molecular Biology
Nundehui Diaz-Lezama, Anne Wolf, Susanne Koch, Anna M. Pfaller, Josef Biber, Xavier Guillonneau, Thomas Langmann, Antje Grosche
Summary: Research shows that PDGFRα in Müller cells plays a crucial role in maintaining retinal function and blocking PDGF signaling may reverse retinal neovascular diseases in certain cases. However, targeting PDGF therapy to Müller cells may have adverse effects on their homeostatic functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anne Enzbrenner, Rahel Zulliger, Josef Biber, Ana Maria Quintela Pousa, Nicole Schaefer, Corinne Stucki, Nicolas Giroud, Marco Berrera, Elod Kortvely, Roland Schmucki, Laura Badi, Antje Grosche, Diana Pauly, Volker Enzmann
Summary: The study found that NaIO3-induced retinal pigment epithelium atrophy leads to retinal degeneration and inflammation, mimicking the characteristics of geographic atrophy. Complement and inflammatory pathways play significant roles in this process, with systemic complement and cytokines/chemokines remaining unchanged.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Adrian Schmalen, Lea Lorenz, Antje Grosche, Diana Pauly, Cornelia A. Deeg, Stefanie M. Hauck
Summary: Muller cells play a crucial role in maintaining retinal homeostasis, but can become gliotic upon pathological changes, with both protective and detrimental consequences. Research suggests their pivotal role in diabetic retinopathy and their important signaling capacity in chronic retinal inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Randy Zauhar, Josef Biber, Yassin Jabri, Mijin Kim, Jian Hu, Lew Kaplan, Anna M. Pfaller, Nicole Schaefer, Volker Enzmann, Ursula Schloetzer-Schrehardt, Tobias Straub, Stefanie M. Hauck, Paul D. Gamlin, Michael B. McFerrin, Jeffrey Messinger, Christianne E. Strang, Christine A. Curcio, Nicholas Dana, Diana Pauly, Antje Grosche, Mingyao Li, Dwight Stambolian
Summary: This study investigates the complement pathway in ocular degeneration, particularly age-related macular degeneration (AMD). The findings reveal that the cellular response to AMD is more robust in the choroid during early stages and more prominent in the retina during late stages. Additionally, the cooperation of different cell types plays a significant role in complement expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kerstin Nagel-Wolfrum, Benjamin R. Fadl, Mirjana M. Becker, Kirsten A. Wunderlich, Jessica Schaefer, Daniel Sturm, Jacques Fritze, Burcu Guer, Lew Kaplan, Tommaso Andreani, Tobias Goldmann, Matthew Brooks, Margaret R. Starostik, Anagha Lokhande, Melissa Apel, Karl R. Fath, Katarina Stingl, Susanne Kohl, Margaret M. DeAngelis, Ursula Schlotzer-Schrehardt, Ivana K. Kim, Leah A. Owen, Jan M. Vetter, Norbert Pfeiffer, Miguel A. Andrade-Navarro, Antje Grosche, Anand Swaroop, Uwe Wolfrum
Summary: Usher syndrome (USH) is a common genetic disorder causing deaf-blindness. This study explores the role of harmonin protein in the pathophysiology of USH1C in the human eye. The localization and expression of harmonin in various retinal cells are correlated with the clinical phenotype observed in USH1C patients. Additionally, the study shows the potential of using harmonin_a1 transcript isoform for gene therapy treatment in USH1C patients.
HUMAN MOLECULAR GENETICS
(2023)
Article
Cell Biology
Valerie Demais, Anne Pohl, Kirsten A. Wunderlich, Anna M. Pfaller, Lew Kaplan, Amelie Barthelemy, Robin Dittrich, Berta Puig, Bernd Giebel, Stefanie M. Hauck, Frank W. Pfrieger, Antje Grosche
Summary: This study reveals the communication mechanism of Muller cells in the retina of adult mice through the release of extracellular vesicles. The Muller cell-specific SNARE protein VAMP5 is identified as a component of extracellular vesicles and is responsive to ischemia. Furthermore, differences in the secretomes between Muller cells and neurons in vitro are uncovered.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Meeting Abstract
Ophthalmology
Uwe Wolfrum, Benjamin Fadl, Mirjana Becker, Daniel Sturm, Kirsten Wunderlich, Burcu Guer, Lew Kaplan, Matthew Brooks, Antje Grosche, Anand Swaroop, Kerstin Nagel-Wolfrum
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Nundehui Diaz-Lezama, Anne Wolf, Susanne Koch, Anna Pfaller, Josef Biber, Xavier P. Guillonneau, Thomas Langmann, Antje A. Grosche
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Neurosciences
L. Kaplan, P. Fuchs, U. Schloetzer-Schrehardt, C. Grimm, K. Franze, M. Goetz, S. Hauck, A. Grosche
Article
Biochemistry & Molecular Biology
Yassin Jabri, Josef Biber, Nundehui Diaz-Lezama, Antje Grosche, Diana Pauly
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Meeting Abstract
Neurosciences
D. Pauly, D. Agarwal, N. Dana, N. Schafer, F. Grassmann, N. R. Zhang, A. K. Gautam, B. H. F. Weber, S. M. Hauck, M. Kim, C. Curcio, D. Stambolian, M. Li, A. Grosche
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
