Article
Biochemistry & Molecular Biology
Baylee J. J. O'Brien, Erika Y. Y. Faraoni, Lincoln N. N. Strickland, Zhibo Ma, Victoria Mota, Samantha Mota, Xuebo Chen, Tingting Mills, Holger K. K. Eltzschig, Kathleen E. E. DelGiorno, Jennifer M. M. Bailey-Lundberg
Summary: Pancreatitis is a common gastrointestinal condition in the US with various causes such as abdominal injury, gallstones, chronic alcohol consumption, or unknown reasons. CD73, a cell surface enzyme, plays a role in resolving inflammation by generating extracellular adenosine. Genetic deletion of CD73 leads to more severe pancreatitis due to decreased adenosine production. Depletion of neutrophils reduces metaplasia and acute pancreatitis in CD73 knockout mice.
Review
Cell Biology
Jianhua Wan, Yuping Ren, Xiaoyu Yang, Xueyang Li, Liang Xia, Nonghua Lu
Summary: Leukocyte invasion, especially neutrophils and monocytes/macrophages, is closely related to the severity of acute pancreatitis, playing a crucial role in the systemic inflammatory response and other organ injuries. The activation and recruitment of neutrophils are major determinants of pancreatic injury and inflammation, with the arrival of the first wave of neutrophils being critical for exacerbating inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Randi J. Ulbricht, Christian A. Rivas, Hailee Marino, Erin Snyder, Dana James, Jamila Makhloufi, Nathan Johnson, Scott Zimmerman, Jianjie Wang
Summary: The sex of an animal impacts glucose sensitivity, and the P2Y2 receptor (P2Y2R) plays a larger role in male mice during acute inflammation. Female mice have reduced fasting plasma glucose levels and better glucose tolerance compared to males. P2Y2R has minimal effect on glucose metabolism in females but is significant in males, particularly in an inflamed state.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Hongxin Kang, Yue Yang, Lv Zhu, Xianlin Zhao, Juan Li, Wenfu Tang, Meihua Wan
Summary: Severe acute pancreatitis (SAP) is a life-threatening abdominal disease. Neutrophil extracellular traps (NETs) play an important role in the occurrence and development of SAP, as well as its fatal complications. This review provides insights into the involvement of NETs in SAP and suggests targeting NETs as a promising strategy in SAP treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Plant Sciences
Chenxia Han, Dan Du, Yongjian Wen, Jiawang Li, Rui Wang, Tao Jin, Jingyu Yang, Na Shi, Kun Jiang, Lihui Deng, Xianghui Fu, Rajarshi Mukherjee, John A. Windsor, Jiwon Hong, Anthony R. Phillips, Robert Sutton, Wei Huang, Tingting Liu, Qing Xia
Summary: Chaiqin chengqi decoction (CQCQD) and its derivatives are effective in the treatment of acute pancreatitis by suppressing neurogenic inflammation and regulating the SP-NK1R signaling pathway, leading to reduced pain and systemic inflammation. Active components such as baicalin, emodin, and magnolol contribute significantly to these effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Xu Wang, Xiao Yuan, Yuting Su, Jing Hu, Qian Ji, Shengqiao Fu, Rongkun Li, Lipeng Hu, Chunhua Dai
Summary: Inflammatory bowel disease (IBD) is a common gastrointestinal disease worldwide. Purinergic signaling is a potential therapeutic target for IBD, with purinergic receptor P2RX1 playing a significant role in regulating inflammation in colon tissues. Genetic knockout of P2RX1 reduces inflammation and neutrophil infiltration, alters gut microbiota, upregulates the indole alkaloid biogenesis pathway, and activates the aryl hydrocarbon receptor (AhR)/IL-22 axis to provide therapeutic benefits. Targeting P2RX1 may offer a novel therapeutic strategy for IBD, with P2RX1 inhibitor enhancing the efficacy of anti-TNF-alpha therapy in mouse colitis models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Nan Ma, Chenchen Yuan, Juanjuan Shi, Qingtian Zhu, Yang Liu, Xiaojie Ma, Baiqiang Li, Weijuan Gong, Jing Xue, Guotao Lu, Weiqin Li, Jieshou Li
Summary: Acute pancreatitis is an inflammatory disease with no effective medical treatment. IL-37 has anti-inflammatory effects and can protect pancreatic cells from death.
Review
Medicine, Research & Experimental
Hassan Mubarak Ishqi, Misha Ali, Rajinder Dawra
Summary: Pancreatitis is an inflammatory disease caused by adverse events in pancreatic acinar cells. The presence of neutrophils at the site of injury can modulate the disease, but the mechanism of their contribution to inflammation is not clear.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xue Xie, Jiulong Zhao, Wei Gao, Jie Chen, Bing Hu, Xiaojun Cai, Yuanyi Zheng
Summary: The study found that PBzyme has potential anti-oxidative and anti-inflammatory effects in the prophylactic treatment of AP, possibly involving inhibition of signaling pathways and scavenging reactive oxygen species. This provides a foundation for the clinical application of PBzyme in the preventive treatment of AP.
Review
Immunology
Shiyu Liu, Peter Szatmary, Jing-wen Lin, Qiqi Wang, Robert Sutton, Lu Chen, Tingting Liu, Wei Huang, Qing Xia
Summary: Acute pancreatitis is a common gastrointestinal disease characterized by acute onset of abdominal pain, often leading to organ failure and death. Monocytes, a type of cells in the innate immune system, are highlighted as key contributors and regulators of the inflammatory response and organ failure in acute pancreatitis, with a special focus on lipid modulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eliana de Souza Bastos Mazuqueli Pereira, Rosanna Tarkany Basting, Henrique Ballassini Abdalla, Aguinaldo Silva Garcez, Marcelo Henrique Napimoga, Juliana Trindade Clemente-Napimoga
Summary: This study found that PBM can inhibit inflammatory chemotaxis, modulate the balance of pro-inflammatory and anti-inflammatory characteristics of inflammatory cells, and reduce the occurrence of temporomandibular joint inflammation.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Cell Biology
Shukun Sun, Yu Han, Chuanxin Zhang, Han Liu, Bailu Wang, Shengchuan Cao, Qiuhuan Yuan, Shujian Wei, Yuguo Chen
Summary: ADK inhibition reduces inflammation and necroptotic acinar cell death in severe acute pancreatitis via the adenosine A(2A) receptor/ER stress pathway, providing new clues for potential therapeutic targets for SAP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jonathon Smith, Aida Menendez Mendez, Mariana Alves, Alberto Parras, Giorgia Conte, Anindya Bhattacharya, Marc Ceusters, Annette Nicke, David C. Henshall, Eva M. Jimenez-Mateos, Tobias Engel
Summary: P2X7 receptor (P2X7R) plays an important role in neonatal seizures, with its deletion reducing seizure severity and overexpression exacerbating seizure severity. P2X7R deficiency leads to an anti-inflammatory phenotype in microglia, and treatment with a P2X7R antagonist can reduce long-lasting brain hyperexcitability. Targeting P2X7R may represent a novel therapeutic strategy for neonatal seizures.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kazuhiro Nishiyama, Kohei Ariyoshi, Akiyuki Nishimura, Yuri Kato, Xinya Mi, Hitoshi Kurose, Sang Geon Kim, Motohiro Nishida
Summary: Nonalcoholic steatohepatitis (NASH) is a disease characterized by inflammation and fibrosis that progresses from nonalcoholic fatty liver (NAFL). The study reveals that the P2Y(6) receptor (P2Y(6)R) is upregulated in NASH liver and positively correlates with the expression of CCL2 and Coll1a1. However, the functional deficiency of P2Y(6)R does not seem to affect the progression of liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Larissa Berloffa Belardin, Keliane Brochu, Christine Legare, Maria Agustina Battistone, Sylvie Breton
Summary: Purinergic receptors are widely expressed throughout the body and play a role in regulating cell function. They activate specific receptors and trigger different signaling pathways to regulate various cellular responses. Purinergic signaling is important for the physiological and pathophysiological processes in the male reproductive system, but our understanding of this is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xi Sun, Yanwei Wang, Tingya Jiang, Xiao Yuan, Zhen Ren, Alex Tuffour, Haitao Liu, Yang Zhou, Jie Gu, Haifeng Shi
Summary: This study investigated the proteomic profile changes induced by cadmium in the kidney using a mouse model. It was found that cadmium regulates kidney metabolism, promotes renal damage and cell migration. The downregulation of Na(+)/H(+) exchange regulatory cofactor (NHERF3) could contribute to renal damage, along with a decrease in transferrin (TRF) in the kidney.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xu Wang, Li-Peng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Lin-Li Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shu-Heng Jiang, Xue-Li Zhang, Zhi-Gang Zhang
Summary: A subset of immunosuppressive P2RX1-negative neutrophils accumulate in the liver metastases of pancreatic ductal adenocarcinoma (PDAC), expressing increased levels of immunosuppressive molecules such as PD-L1 and having enhanced mitochondrial metabolism. The upregulation of the transcription factor Nrf2 in P2RX1-deficient neutrophils is associated with PD-L1 expression and metabolic reprogramming, contributing to the evasion of antitumor immunity by metastatic PDAC tumors.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Wanjun Yu, Fei Ye, Xiao Yuan, Yali Ma, Chaoming Mao, Xiaoqin Li, Jian Li, Chunhua Dai, Fenhong Qian, Junrong Li, Xiujuan Fan, Yuepeng Zhou, Deqiang Wang, Zhenhong Guo, Huazhang An, Minghui Zhang, Deyu Chen, Sheng Xia
Summary: This study aims to evaluate the efficacy and safety of CD8 + CD56+ NKT cell immunotherapy combined with gefitinib in patients with advanced EGFR-mutated NSCLC. The effectiveness of this treatment is being assessed based on several factors including progression-free survival, overall response rate, and overall survival, with ongoing recruitment and data collection.
Article
Pharmacology & Pharmacy
Shaoyong Zhuang, Shengqiang Xia, Peiqi Huang, Jiajin Wu, Junwen Qu, Ruoyang Chen, Nan Sun, Dawei Li, Haoyu Wu, Ming Zhang, Jianjun Zhang, Xiaodong Yuan, Xu Wang
Summary: Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury, with mechanisms not fully elucidated. Results from RNA sequencing showed disrupted mitochondrial dynamics and upregulated expression of P2RX1 in renal IRI. P2RX1 promoted the formation of NETs, leading to impairment of mitochondrial dynamics.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Yanyan Zhu, Yumeng Huang, Qian Ji, Shengqiao Fu, Jia Gu, Ningzheng Tai, Xu Wang
Summary: The extracellular matrix (ECM) is a crucial microenvironment for cell survival, interacting with neutrophils to play important roles in inflammation. Neutrophils can mediate ECM remodeling by providing specific matrix-remodeling enzymes, generating neutrophil extracellular traps and releasing exosomes, while ECM can remodel the inflammatory microenvironment by regulating neutrophil function.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Xu Wang, Xiao Yuan, Yuting Su, Jing Hu, Qian Ji, Shengqiao Fu, Rongkun Li, Lipeng Hu, Chunhua Dai
Summary: Inflammatory bowel disease (IBD) is a common gastrointestinal disease worldwide. Purinergic signaling is a potential therapeutic target for IBD, with purinergic receptor P2RX1 playing a significant role in regulating inflammation in colon tissues. Genetic knockout of P2RX1 reduces inflammation and neutrophil infiltration, alters gut microbiota, upregulates the indole alkaloid biogenesis pathway, and activates the aryl hydrocarbon receptor (AhR)/IL-22 axis to provide therapeutic benefits. Targeting P2RX1 may offer a novel therapeutic strategy for IBD, with P2RX1 inhibitor enhancing the efficacy of anti-TNF-alpha therapy in mouse colitis models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mengtian Wan, Yuzhu Ding, Zheng Li, Xu Wang, Min Xu
Summary: This paper discusses metabolic reprogramming in tumor cells and the influence of metabolite by-products on the immune microenvironment, providing novel insights into tumor immunotherapy.
Article
Oncology
Dongfang Dai, Hongping Zhou, Li Yin, Fei Ye, Xiao Yuan, Tao You, Xiaohui Zhao, Weiguo Long, Deqiang Wang, Xia He, Jifeng Feng, Deyu Chen
Summary: PELI1 regulates the sensitivity of tumor cells to radiotherapy by modulating the expression of noncanonical NF-kappa B induced by IR, ultimately promoting apoptosis in tumor cells.
MOLECULAR ONCOLOGY
(2022)
Article
Immunology
Jing Hu, Qian Ji, Fei Chen, Xiaoqin Gong, Chuansheng Chen, Kaijun Zhang, Ye Hua, Jinlei Wang, Rongkun Li, Xu Wang, Chunhua Dai, Ye Tian
Summary: Neutrophils play a critical role in radiation-induced intestinal injury, with migration mediated by the CXCR2 receptor. Inhibiting the CXCR2 signaling pathway effectively suppresses neutrophil chemotaxis and tissue damage.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Wanjun Yu, Xiao Yuan, Fei Ye, Chaoming Mao, Jian Li, Minghui Zhang, Deyu Chen, Sheng Xia
Summary: Gefitinib has demonstrated good efficacy in patients with EGFR mutation-positive non-small-cell lung cancer, but the development of acquired resistance is inevitable. This case report presents a potential effective strategy for delaying gefitinib resistance and extending progression-free survival in NSCLC patients with common EGFR mutations by using a combination of allogeneic haploidentical CD8(+) CD56(+) natural killer T cells and gefitinib.
Review
Oncology
Yufei Yang, Ting Zhu, Xu Wang, Fen Xiong, Zhangmin Hu, Xuehan Qiao, Xiao Yuan, Deqiang Wang
Summary: ACSL3 and ACSL4, members of the long-chain fatty acyl CoA synthetase family, play roles in various cancer cells. They are essential for ferroptosis and have implications in cancer initiation, development, and treatment.
Article
Multidisciplinary Sciences
Qing Li, Xiao-Xin Zhang, Li-Peng Hu, Bo Ni, Dong-Xue Li, Xu Wang, Shu-Heng Jiang, Hui Li, Min-Wei Yang, Yong-Sheng Jiang, Chun-Jie Xu, Xue-Li Zhang, Yan-Li Zhang, Pei-Qi Huang, Qin Yang, Yang Zhou, Jian-ren Gu, Gary Gui-Shan Xiao, Yong-wei Sun, Jun Li, Zhi-Gang Zhang
Summary: This study investigates the mechanisms and drivers of pancreatic ductal adenocarcinoma (PDAC) metastasis to the liver. It identifies SLIT2 and its receptor ROBO1 as important molecules in this process. The study demonstrates that SLIT2-ROBO1-mediated coadaptation facilitates the implantation and outgrowth of PDAC disseminated tumor cells (DTCs) in the liver. The study also shows that the dependence receptor (DR) characteristics of ROBO1 support coadaptation in the premetastatic niche (PMN) and macrometastatic niche (MMN).
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Hao Zuo, Mengjie Yang, Qian Ji, Shengqiao Fu, Xi Pu, Xu Zhang, Xu Wang
Summary: Neutrophil extracellular traps (NETs) play a significant role in tumor microenvironment (TME) by interacting with stromal components, immune cells, and cancer cells, affecting cancer progression and metastasis, and limiting the efficacy of immunotherapy.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)