Merazin hydrate produces rapid antidepressant effect by activating CaMKII to promote neuronal activities and proliferation in hippocampus

Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin

(2023) Pasha A. Davoudian et al.   ACS Chemical Neuroscience

Comorbidity of ketamine dependence with major depressive disorder increases the vulnerability to neuroaxonal pathology

(2023) Ming-Chyi Huang et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Antidepressant-like effect of CP-101,606: Evidence of mTOR pathway activation

(2023) Yu Qin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induces Depression-Like Behavior and Learning-Memory Impairment: A Possible Link with Decreased Hippocampal Neurogenesis and Astrocyte Activation

(2023) Nikola Šutulović et al.   Oxidative Medicine and Cellular Longevity

Multi-omic modeling of antidepressant response implicates dynamic immune and inflammatory changes in individuals who respond to treatment

(2023) Shih-Chieh Fuh et al.   PLoS One

Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways

(2023) Dehua Liao et al.   PSYCHOPHARMACOLOGY

Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway

(2023) Jia-Hao Li et al.   Frontiers in Microbiology

Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

(2023) Jared Kopelman et al.   Translational Psychiatry

Biological effects of exposure to 2650 MHz electromagnetic radiation on the behavior, learning, and memory of mice

(2023) Rongqi Zheng et al.   Brain and Behavior

The effects of chronic unpredicted mild stress on maternal negative emotions and gut microbiota and metabolites in pregnant rats

(2023) Rui Wang et al.   PeerJ

Nos1+ and Nos1− excitatory neurons in the BLA regulate anxiety- and depression-related behaviors oppositely

(2023) Cheng-Yun Cai et al.   JOURNAL OF AFFECTIVE DISORDERS

Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain

(2023) Zheng-Wei Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour

(2023) Alessandra Borsini et al.   MOLECULAR PSYCHIATRY

Longitudinal effects of ketamine on cell proliferation and death in the CNS of zebrafish

(2023) C. Santos et al.   NEUROTOXICOLOGY

Major Depression and Its Recurrences: Life Course Matters

(2022) Scott M. Monroe et al.   Annual Review of Clinical Psychology

Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

(2022) Fabio Papes et al.   Nature Communications

Transcriptional Activation, Deactivation and Rebound Patterns in Cortex, Hippocampus and Amygdala in Response to Ketamine Infusion in Rats

(2022) Jenny J. Kim et al.   Frontiers in Molecular Neuroscience

Physiological functions and roles in cancer of the proliferation marker Ki-67

(2022) Nuria Andrés-Sánchez et al.   JOURNAL OF CELL SCIENCE

The efficacy and safety of esketamine in the treatment of major depressive disorder with suicidal ideation: study protocol for a randomized controlled trial

(2022) Haiyan Liu et al.   BMC Psychiatry

Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway

(2022) Jing Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Impact of alcohol exposure on neural development and network formation in human cortical organoids

(2022) Jason W. Adams et al.   MOLECULAR PSYCHIATRY

Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology

(2022) Daniel F. Kelly et al.   NEUROSURGERY

Getting a Grip on Ki-67

(2021) Regan Fulton   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression

(2021) Guoli Wang et al.   Journal of Ginseng Research

Combining psychopharmacotherapy and psychotherapy is not associated with better treatment outcome in major depressive disorder - evidence from the European Group for the Study of Resistant Depression

(2021) Lucie Bartova et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors

(2021) Vesna Lazarevic et al.   MOLECULAR PSYCHIATRY

Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors

(2021) Jinxin Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus

(2021) Chao Lu et al.   ACS Chemical Neuroscience

Electroacupuncture Ameliorates Depression-Like Behaviour in Rats by Enhancing Synaptic Plasticity via the GluN2B/CaMKII/CREB Signalling Pathway

(2021) Kun Zhang et al.   Evidence-based Complementary and Alternative Medicine

Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity

(2021) Ingrid Prata Mendonça et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model

(2021) Wei Li et al.   NEUROPHARMACOLOGY

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

(2020) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus

(2020) Lei Wu et al.   ACS Chemical Neuroscience

Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

(2020) Xiao-Hui Tang et al.   Journal of Neuroinflammation

Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

(2020) Lei Wu et al.   PHYTOTHERAPY RESEARCH

Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway

(2020) Lu Bai et al.   Frontiers in Behavioral Neuroscience

Pharmacokinetic study of precisely representative antidepressant, prokinetic, anti-inflammatory and anti-oxidative compounds from Fructus aurantii and Magnolia Bark

(2019) Shaoqi Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine

(2018) Chinnakkaruppan Adaikkan et al.   BIOLOGICAL PSYCHIATRY

Propofol Regulates Neural Stem Cell Proliferation and Differentiation via Calmodulin-Dependent Protein Kinase II/AMPK/ATF5 Signaling Axis

(2018) Chao Liang et al.   ANESTHESIA AND ANALGESIA

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

(2018) Qiqi Song et al.   Journal of Neuroinflammation

Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells

(2018) Ruchee Phonchai et al.   NEUROCHEMISTRY INTERNATIONAL

Identifying fast-onset antidepressants using rodent models

(2017) M J Ramaker et al.   MOLECULAR PSYCHIATRY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Persistent CaMKII Activation Mediates Learning-Induced Long-Lasting Enhancement of Synaptic Inhibition

(2015) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons

(2014) Sung Woo Park et al.   BIPOLAR DISORDERS

NMDA receptor dysregulation in chronic state: A possible mechanism underlying depression with BDNF downregulation

(2014) Carol E. Vásquez et al.   NEUROCHEMISTRY INTERNATIONAL

Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its Application

(2012) Rong Fan et al.   Evidence-based Complementary and Alternative Medicine

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE