IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

On phagocytes and macular degeneration

(2017) Xavier Guillonneau et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina

(2017) Iris Haumann et al.   PLoS One

The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death

(2016) Riccardo Natoli et al.   CURRENT EYE RESEARCH

Subretinal mononuclear phagocytes induce cone segment loss via IL-1β

(2016) Chiara M Eandi et al.   eLife

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

(2015) Najate Aït-Ali et al.   CELL

Interleukin 1β Regulation of the System xc−Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR

(2015) Jingxue Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes

(2015) Soraya Scuderi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1  Secretion and Photoreceptor Neurodegeneration

(2015) S. J. Hu et al.   JOURNAL OF NEUROSCIENCE

The Proteome of Native Adult Müller Glial Cells From Murine Retina

(2015) Antje Grosche et al.   MOLECULAR & CELLULAR PROTEOMICS

CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice

(2013) Florian Sennlaub et al.   EMBO Molecular Medicine

Role of interleukin-1β in hypoxia-induced depression of glutamate uptake in retinal Müller cells

(2013) Chongda Chen et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal

(2013) Hideo Kohno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa

(2012) Congrong Guo et al.   EXPERIMENTAL EYE RESEARCH

Rapid glutamate receptor 2 trafficking during retinal degeneration

(2012) Yanhua Lin et al.   Molecular Neurodegeneration

System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo

(2011) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Neuron-Specific Effects of Interleukin-1  Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β

(2010) Nicole A. Jackman et al.   GLIA

The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis

(2008) Natalie A. Prow et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

(2008) James B Koprich et al.   Journal of Neuroinflammation

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE