Development of copper based drugs, radiopharmaceuticals and medical materials

Detection of Cancer Metastases with a Dual-labeled Near-Infrared/Position Emission Tomography Imaging Agent

(2014) Lakshmi Sampath et al.   Translational Oncology

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of ternary complexes of copper with salicylaldehyde-amino acid Schiff base coordination compounds on the proliferation of BGC823 cells

(2012) Ai-Juan Guo et al.   Chinese Journal of Cancer

Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers

(2011) Won Il Choi et al.   ACS Nano

Cytotoxic Origin of Copper(II) Oxide Nanoparticles: Comparative Studies with Micron-Sized Particles, Leachate, and Metal Salts

(2011) Cindy Gunawan et al.   ACS Nano

Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study

(2011) Yumiko Minagawa et al.   ANNALS OF NUCLEAR MEDICINE

Improving the separation of Cu(II) from Zn(II) based on an anion exchanger for the preparation a 62Zn/62Cu generator

(2011) K.M. El-Azony   APPLIED RADIATION AND ISOTOPES

Development of a large scale production of 67Cu from 68Zn at the high energy proton accelerator: Closing the 68Zn cycle

(2011) Dmitri G. Medvedev et al.   APPLIED RADIATION AND ISOTOPES

Production of 61Cu using natural cobalt target and its separation using ascorbic acid and common anion exchange resin

(2011) Sujata Saha Das et al.   APPLIED RADIATION AND ISOTOPES

Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease

(2011) Makoto Isozaki et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Synthesis, superoxide dismutase, nuclease, and anticancer activities of copper(II) complexes incorporating bis(2-picolyl)amine with different counter anions

(2011) Mohamed M. Ibrahim et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel Cu(II)-RGD-octapeptides: Synthesis, coordination mode, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and correlation of sequence with nano-structure

(2011) Ning Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Noninvasive visualization and quantification of tumor αVβ3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4

(2011) Zhao-Hui Jin et al.   NUCLEAR MEDICINE AND BIOLOGY

Studies on stabilities of some human chorionic gonadotropin complexes with β-emitting radionuclides

(2010) Moumita Maiti et al.   APPLIED RADIATION AND ISOTOPES

Polyurethane nanofibers containing copper nanoparticles as future materials

(2010) Faheem A. Sheikh et al.   APPLIED SURFACE SCIENCE

Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor Positive Tumor with a64Cu Labeled Affibody Protein

(2010) Zheng Miao et al.   BIOCONJUGATE CHEMISTRY

RGD–cyclam conjugate: Synthesis and potential application for positron emission tomography

(2010) Mathieu Galibert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

(2010) Thaddeus J. Wadas et al.   CHEMICAL REVIEWS

Electrochemical behavior of cysteine at a CuGeO3 nanowires modified glassy carbon electrode

(2010) YongPing Dong et al.   ELECTROCHIMICA ACTA

Synthesis and reactivity studies on new copper(II) complexes: DNA binding, generation of phenoxyl radical, SOD and nuclease activities

(2010) Kaushik Ghosh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action

(2010) Ajanta Chakraborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis of ternary CuInS2/ZnS quantum dot bioconjugates and their applications for targeted cancer bioimaging

(2010) Ken-Tye Yong et al.   Integrative Biology

Renal Toxicity of Radiolabeled Peptides and Antibody Fragments: Mechanisms, Impact on Radionuclide Therapy, and Strategies for Prevention

(2010) E. Vegt et al.   JOURNAL OF NUCLEAR MEDICINE

The significance of copper chelators in clinical and experimental application

(2010) Xueqin Ding et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Copper sulfide nanoparticles for photothermal ablation of tumor cells

(2010) Yuebin Li et al.   Nanomedicine

Copper complex of a pyridine-modified poly(amidoamine) dendrimer as a chemical nuclease: synthetic and catalytic study

(2010) Chai-Lin Kao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM

(2010) Jason L.J. Dearling et al.   NUCLEAR MEDICINE AND BIOLOGY

Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists, [64Cu-NO2A-(X)-BBN(7–14)NH2], in a prostate tumor xenografted mouse model

(2010) Stephanie R. Lane et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of positron emission tomography probe of 64Cu-labeled anti-C-kit 12A8 Fab to measure protooncogene C-kit expression

(2010) Chisato Yoshida et al.   NUCLEAR MEDICINE AND BIOLOGY

Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma

(2010) Yukie Yoshii et al.   NUCLEAR MEDICINE AND BIOLOGY

A Novel Anti-Influenza Copper Oxide Containing Respiratory Face Mask

(2010) Gadi Borkow et al.   PLoS One

Gold Nanocages as Photothermal Transducers for Cancer Treatment

(2010) Jingyi Chen et al.   Small

Nanoparticle cytotoxicity depends on intracellular solubility: Comparison of stabilized copper metal and degradable copper oxide nanoparticles

(2010) Andreas M. Studer et al.   TOXICOLOGY LETTERS

Alternative method for 64Cu radioisotope production

(2009) Van So Le et al.   APPLIED RADIATION AND ISOTOPES

Synthesis, structural analysis and anticonvulsant activity of a ternary Cu(II) mononuclear complex containing 1,10-phenanthroline and the leading antiepileptic drug valproic acid

(2009) Maité Sylla-Iyarreta Veitía et al.   BIOCHIMIE

A highly sensitive nonenzymatic glucose sensor based on CuO nanoparticles-modified carbon nanotube electrode

(2009) Liao-Chuan Jiang et al.   BIOSENSORS & BIOELECTRONICS

Cellular copper management—a draft user's guide

(2009) Ivano Bertini et al.   COORDINATION CHEMISTRY REVIEWS

Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities

(2009) Thummaruk Suksrichavalit et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) – Potential combination agents for the PET imaging of hypoxia

(2009) Paul D. Bonnitcha et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and cytotoxic activities of chloropyridylimineplatinum(II) and chloropyridyliminecopper(II) surface-functionalized poly(amidoamine) dendrimers

(2009) Xinxin Zhao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Superoxidedismutase-mimetic copper(II) complexes containing saccharinate and 4-aminopyridine/4-cyanopyridine

(2009) Evelina G. Ferrer et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Reducing the risk of skin pathologies in diabetics by using copper impregnated socks

(2009) Gadi Borkow et al.   MEDICAL HYPOTHESES

Copper–taurine (CT): A potential organic compound to facilitate infected wound healing

(2009) Xiliang Tian et al.   MEDICAL HYPOTHESES

Toxicity issues in the application of carbon nanotubes to biological systems

(2009) Constantine P. Firme et al.   Nanomedicine-Nanotechnology Biology and Medicine

Quantitative small animal PET imaging with nonconventional nuclides

(2009) Xiaodong Liu et al.   NUCLEAR MEDICINE AND BIOLOGY

In vitro and in vivo analysis of [64Cu-NO2A-8-Aoc-BBN(7–14)NH2]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors

(2009) Adam F. Prasanphanich et al.   NUCLEAR MEDICINE AND BIOLOGY

True radiotracers: Cu-64 targeting vectors based upon bombesin peptide

(2009) Timothy J. Hoffman et al.   NUCLEAR MEDICINE AND BIOLOGY

64Cu-Labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity

(2009) Lihui Wei et al.   NUCLEAR MEDICINE AND BIOLOGY

Copper(II) complexes of methylated glycine derivatives: Effect of methyl substituent on their DNA binding and nucleolytic property

(2009) Hoi Ling Seng et al.   POLYHEDRON

Physicochemical characterization of Cu(II) complexes with SOD-like activity, theoretical studies and biological assays

(2009) Ana C. González-Baró et al.   POLYHEDRON

Copper nanoparticles–carbon microparticles nanocomposite for electrooxidation and sensitive detection of sotalol

(2009) H. Heli et al.   SENSORS AND ACTUATORS B-CHEMICAL

Cadmium-containing nanoparticles: Perspectives on pharmacology and toxicology of quantum dots☆

(2009) Beverly A. Rzigalinski et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

PET of Hypoxia and Perfusion with62Cu-ATSM and62Cu-PTSM Using a62Zn/62Cu Generator

(2008) Terence Z. Wong et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu–DOTA–HSA as a blood pool agent

(2008) Guiyang Hao et al.   APPLIED RADIATION AND ISOTOPES

Synthesis of64Cu-Labeled Magnetic Nanoparticles for Multimodal Imaging

(2008) Benjamin R. Jarrett et al.   BIOCONJUGATE CHEMISTRY

A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pyloris ligation model (Shay model)

(2008) Muobarak Jaber F.-A. Tuorkey et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin αvβ3 and αvβ5 ligands

(2008) Maria Salvati et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Receptor-Binding, Biodistribution, and Metabolism Studies of 64Cu-DOTA-Cetuximab, a PET-Imaging Agent for Epidermal Growth-Factor Receptor-Positive Tumors

(2008) Wen Ping Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Tumor Hypoxia Detected by Positron Emission Tomography with 60Cu-ATSM as a Predictor of Response and Survival in Patients Undergoing Neoadjuvant Chemoradiotherapy for Rectal Carcinoma: A Pilot Study

(2008) David W. Dietz et al.   DISEASES OF THE COLON & RECTUM

Synthesis, structure and biological activity of copper(II) complexes of 4-(2-pyridylmethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione and 4-(2-pyridylethyl)-1,7-dimethyl-1,4,7-triazonane-2,6-dione

(2008) Amit P. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNA binding and antimicrobial studies of polymer–copper(II) complexes containing 1,10-phenanthroline and l-phenylalanine ligands

(2008) Rajendran Senthil Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots

(2008) Kai Chen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vitro and in vivo studies of the dermally absorbed Cu(II) complexes of N5O2 donor ligands – Potential anti-inflammatory drugs

(2008) Sebusi Odisitse et al.   INORGANICA CHIMICA ACTA

The effect of complexation of Cu(II) with P6A peptide and its analogs on their thrombolytic activities

(2008) Mei Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessing Tumor Hypoxia in Cervical Cancer by PET with 60Cu-Labeled Diacetyl-Bis(N4-Methylthiosemicarbazone)

(2008) F. Dehdashti et al.   JOURNAL OF NUCLEAR MEDICINE

PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)-Conjugated Radiolabeled Iron Oxide Nanoparticles

(2008) H.-Y. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Coordination of Thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to Nanoscale Self-assembly, Increase of Thrombolytic Activity and Additional Vasodilation

(2008) Xue Ren et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Production of 67Cu via the 68Zn(p,2p)67Cu reaction and recovery of 68Zn target

(2008) T. Katabuchi et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Preparation and characterization of copper metal nanoparticles using dendrimers as protectively colloids

(2008) Lei Jin et al.   MATERIALS CHEMISTRY AND PHYSICS

Copper Complexes of Nicotinic-Aromatic Carboxylic Acids as Superoxide Dismutase Mimetics

(2008) Thummaruk Suksrichavalit et al.   MOLECULES

Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives

(2008) Hua Zhang et al.   Nanomedicine

Species dependence of [64Cu]Cu-Bis(thiosemicarbazone) radiopharmaceutical binding to serum albumins

(2008) Nathan E. Basken et al.   NUCLEAR MEDICINE AND BIOLOGY

Novel unsymmetrical macrocyclic dicompartmental binuclear copper(II) complexes bearing 4- and 6-coordination sites: Electrochemical, magnetic, catalytic and antimicrobial studies

(2008) S. Sreedaran et al.   POLYHEDRON

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spectroscopic characterizations and biological studies on newly synthesized Cu2+ and Zn2+ complexes of first and second generation dendrimers

(2008) Moamen S. Refat et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Copper(II) complexes with bioactive carboxyamide: Synthesis, characterization and biological activity

(2007) Bibhesh K. Singh et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY