Studies on stabilities of some human chorionic gonadotropin complexes with β-emitting radionuclides

Human chorionic gonadotropin (hCG) is a peptide hormone, whose one of the structural subunits is identical to that of thyroid-stimulating hormone (TSH). As a consequence, the receptors of TSH also act as receptor for hCG hormone. Keeping in mind this interesting property of hCG we have studied the complex formation ability of various no-carrier-added beta-emitting isotopes of Cu-61 (3.3 h), Zn-62 (9.2 h), Nb-90 (14.60 h) and Mo-99 (66.02 h) with hCG molecule. Stability of the hCG-M (M = metal ions) complexes was investigated by dialysis with respect to triple distilled water and ringer lactate solution, which has the same composition as extracellular fluid. (C) 2010 Elsevier Ltd. All rights reserved.